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Regulation of Ornithine Decarboxylase
Open accessAbstract
Ornithine decarboxylase (ODC) initiates the polyamine biosynthetic pathway. The amount of ODC is altered in response to many growth factors, oncogenes, and tumor promoters and to changes in polyamine levels. Susceptibility to tumor development is increased in transgenic mice expressing high levels of ODC and is decreased in mice with reduced ODC due to loss of one ODC allele or elevated expression of antizyme, a protein that stimulates ODC degradation. This review describes key factors that contribute to the regulation of ODC levels, which can occur at the levels of transcription, translation, and protein turnover.
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Cited by
Polyamines: essential factors for growth and survival
Kusano, T., Berberich, T., Tateda, C., & Takahashi, Y. (2008) · Planta · doi:10.1007/s00425-008-0772-7 · Cited by 892
Mammalian polyamine metabolism and function
Pegg, A. E. (2009) · IUBMB Life · doi:10.1002/iub.230 · Cited by 783
Self-citationFunctions of Polyamines in Mammals
Pegg, A. E. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.731661 · Cited by 718
Self-citationRemaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658
Polyamines and cancer: implications for chemotherapy and chemoprevention
Nowotarski, S. L., Woster, P. M., & Casero, R. A. (2013) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2013.3 · Cited by 305
Metadata
- Authors
- Pegg, A. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 281
- Issue
- 21
- Pages
- 14529-14532
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1991407392
- Cited by
- 476
- References
- 0
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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