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Intracellular Organic Osmolytes: Function and Regulation
Open accessAbstract
Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines.
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Yancey, P. H., Blake, W. R., & Conley, J. (2002) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00182-4 · Cited by 218
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Schneider, S. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.012 · Cited by 118
Hoffmann, T., Warmbold, B., Smits, S. H. J., Tschapek, B., Ronzheimer, S., Bashir, A., Chen, C., Rolbetzki, A., Pittelkow, M., Jebbar, M., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.13999 · Cited by 69
Cañavate, J.-P., Hachero-Cruzado, I., Pérez-Gavilán, C., & Fernández-Díaz, C. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02258-2 · Cited by 14
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Khandwala, C. B., Sarkar, P., Schmidt, H. B., Ma, M., Pusapati, G. V., Lamoliatte, F., Kinnebrew, M., Patel, B. B., Tillo, D., Lebensohn, A. M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu3194 · Cited by 11
Metadata
- Authors
- Burg, M. B., & Ferraris, J. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 283
- Issue
- 12
- Pages
- 7309-7313
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2072676547
- Cited by
- 664
- References
- 1
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
