The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation
Open accessAbstract
Although investigation of the toxicological and physiological actions of alpha/beta-unsaturated 4-hydroxyalkenals has made great progress over the last 2 decades, understanding of the chemical mechanism of formation of 4-hydroxynonenal and related aldehydes has advanced much less. The aim of this review is to discuss mechanistic evidence for these non-enzymatic routes, especially of the underappreciated intermolecular pathways that involve dimerized and oligomerized fatty acid derivatives as key intermediates. These cross-molecular reactions of fatty acid peroxyls have also important implications for understanding of the basic initiation and propagation steps during lipid peroxidation and the nature of the products that arise.
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Cites
Benedetti, A., Comporti, M., & Esterbauer, H. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90209-x · Cited by 1,085
Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins
Lee, S. H., Oe, T., & Blair, I. A. (2001) · Science · doi:10.1126/science.1059501 · Cited by 414
Bolland, J. L. (1949) · Quarterly Reviews, Chemical Society · doi:10.1039/qr9490300001 · Cited by 400
Reactions of 4-hydroxynonenal with proteins and cellular targets
Petersen, D. R., & Doorn, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.012 · Cited by 392
Bateman, L. (1954) · Quarterly Reviews, Chemical Society · doi:10.1039/qr9540800147 · Cited by 373
Protein Adducts Generated from Products of Lipid Oxidation: Focus on HNE and ONE
Sayre, L. M., Lin, D., Yuan, Q., Zhu, X., & Tang, X. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600959508 · Cited by 365
Two Distinct Pathways of Formation of 4-Hydroxynonenal
Schneider, C., Tallman, K. A., Porter, N. A., & Brash, A. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101821200 · Cited by 313
Self-citationEndogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death
West, J. D., & Marnett, L. J. (2006) · Chemical Research in Toxicology · doi:10.1021/tx050321u · Cited by 295
Characterization of 4-Oxo-2-nonenal as a Novel Product of Lipid Peroxidation
Lee, S. H., & Blair, I. A. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000101a · Cited by 242
Pryor, W. A., & Porter, N. A. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90153-a · Cited by 230
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Cao, J. Y., & Dixon, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2194-1 · Cited by 1,515
Manolagas, S. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0024 · Cited by 1,200
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Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972
Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G. (2013) · Free Radical Research · doi:10.3109/10715762.2013.815348 · Cited by 823
Metadata
- Authors
- Schneider, C., Porter, N. A., & Brash, A. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 283
- Issue
- 23
- Pages
- 15539-15543
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2077805320
- Cited by
- 275
- References
- 30
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.