Nitro-fatty acid formation and signaling
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A review, on the nitro-fatty acid formation and signaling, discussing mechanisms of fatty acid nitration; chem. reactivities of Nitro-fatty acids; and signaling action of Nitro-fatty acids.
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These reactions lead to generation of electrophilic nitro-fatty acid signaling mediators, including NO2-CLA and S-nitrosothiol derivatives, detected at increased concentrations in systemic circulation following oral consumption of nitrate.
“These reactions also lead to the generation of electrophilic nitro-fatty acid (NO2-FA) signaling mediators, including NO2-conjugated linoleic acid (NO2-CLA) and S-nitrosothiol derivatives, all of which can be detected at increased concentrations in the systemic circulation following oral consumption of nitrate[72,92–96].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [93]
Under low pH, non-enzymatic reduction of nitrite to NO produces an intermediate nitrogen dioxide radical that can react with dietary, unsaturated, electrophilic fatty acids such as oleic and linoleic acid, to form nitro-conjugated fatty acids and S-nitrosothiol derivatives.
“Under low pH, non-enzymatic reduction of nitrite to NO produces an intermediate nitrogen dioxide radical that can react with dietary, unsaturated, electrophilic fatty acids such as the essential FAs, oleic and linoleic acid, to form nitro-conjugated fatty acids and S-nitrosothiol derivatives[93,384].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [93]
Nitroalkenes transduce signaling reactions by covalently modifying nucleophilic protein targets and altering their structure and function.
“Nitroalkenes transduce signaling reactions by covalently modifying nucleophilic protein targets and altering their structure and function6.”
From Nitro-oleic acid inhibits angiotensin II-induced hypertension (2010) · cites this paper as [6]
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References 55 · Cited by 265
Research works printed but not linked: 5
- Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 1620 -1624
- Lim, D. G., Sweeney, S., Bloodsworth, A., White, C. R., Chumley, P. H., Krishna, N. R., Schopfer, F., O'Donnell, V. B., Eiserich, J. P., and Freeman, B. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15941-15946
- Wright, M. M., Schopfer, F. J., Baker, P. R. S., Vidyasagar, V., Powell, P., Chumley, P., Iles, K. E., Freeman, B. A., and Agarwal, A. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 4299 -4304
- Schopfer, F. J., Lin, Y., Baker, P. R., Cui, T., Garcia-Barrio, M., Zhang, J., Chen, K., Chen, Y. E., and Freeman, B. A. (2005) Proc. Natl. Acad. Sci.
- Uchida, K., and Stadtman, E. R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 4544 -4548
- Authors
- Freeman, B. A., Baker, P. R. S., Schopfer, F. J., Woodcock, S. R., Napolitano, A., & d'Ischia, M.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 283
- Issue
- 23
- Pages
- 15515-15519
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2414282
- OpenAlex
- W1982380290
- Cited by
- 265
- References
- 55
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 17 · 2014: 21 · 2013: 14 · 2012: 15
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion, cc-by)
- Funders
- American Diabetes Association
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL64937, R01HL064937, R01HL058115, R01-HL-58115)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitro-fatty acids
- MeSH terms
- Animals, Arachidonic Acids, Humans, Inflammation, Nitric Oxide, Protein Processing, Post-Translational, Stereoisomerism, Lipid Peroxidation, Signal Transduction, Tocopherols
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