Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation
Saito, Takashi, Mihira, Naomi, Matsuba, Yukio, Sasaguri, Hiroki, Hashimoto, Shoko, Narasimhan, Sneha, Zhang, Bin, Murayama, Shigeo, Higuchi, Makoto, Lee, Virginia M.Y., Trojanowski, John Q., Saido, Takaomi C.·2019·Journal of Biological Chemistry
Cited by (248)
Items 201–248 of 248
- Animal Models and Ethics in the Testing of Drugs for Alzheimer’s DiseaseParikshit Roychowdhury, Antony Justin, Mirunalini Gobinath, Veera Venkata Satyanarayana Reddy Karri, Gowthamarajan Kuppusamy · 2024 · Springer eBooks
- Exploring sex-specific alterations in early Alzheimer’s disease using network MRI analysesInes Ben Abdallah, Marion Sourty, Marion Rame, Laëtitia Degiorgis, Aminé Isik, Chantal Mathis, Laura Adela Harsan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Reviewer #2 (Public review): Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease2025 · eLife
- Author response: Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s diseaseVibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi C. Saido, Toh Hean Ch’ng · 2025 · eLife
- Reviewer #2 (Public review): Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease2025 · eLife
- Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s diseaseMei-Lun Huang, Yusuke Suzuki, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Itaru Imayoshi · 2025 · eLife
- Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s diseaseMei-Lun Huang, Yusuke Suzuki, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Itaru Imayoshi · 2025 · eLife
- Amyloid- and Tau-Targeted Therapies in Alzheimer’s DiseaseAlexander J. Rajic, Douglas R Galasko, Mark H. Tuszynski · 2025 · Springer eBooks
- BAG3 in traumatic brain injury: A cell-type-specific modulator of tau hyperphosphorylationNicholas Sweeney, Tae Yeon Kim, Hongjun Fu · 2025 · Neural Regeneration Research
- Stem Cell-Derived 3D Models to Study Alzheimer’s DiseaseJosé Inzunza, Aphrodite Demetriou, Patricia Muñoz, Jonathan Arias, Ivan Nalvarte · 2025 · Stem cell biology and regenerative medicine
- Additional file 3 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 12 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 1 of Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type miceMarangelie Criado‐Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu‐Abdelahad, Laura J. Blair · 2021 · Figshare
- Additional file 5 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 2 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 11 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 10 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 6 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 4 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 4 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 9 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 1 of Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tauChristina F. de Veij Mestdagh, Witte, M. E., Wiep Scheper, A.B. Smit, Henning, R. H., Ronald E. van Kesteren · 2024 · Figshare
- Additional file 1 of Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microgliaDiana P. Benítez, Jiang, Shenyi, Jack I. Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Wong, Natalie, Katie M. Stringer, Karina S. Vitanova, Smith, Victoria C. et al. · 2021 · Figshare
- Additional file 3 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Additional file 6 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosisRicheng Jiang, Una Smailović, Hazal Haytural, Betty Marije Tijms, Li, Hao, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Gobom, Johan et al. · 2022 · Figshare
- Mouse models of Alzheimer’s disease pathologySunwoo Kim, Nora E. Gray · 2025 · Elsevier eBooks
- A critical appraisal of the link between apolipoprotein E and TauSudeshna Das, Bradley T. Hyman, Alberto Serrano‐Pozo · 2026 · Current Opinion in Neurology
- Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer’s diseaseArun Reddy Ravula, Ayaka Hagita-Tatsumoto, Brendan J. Gibbs, Nibedita Basu Ray, J. W Ellison, Alejandro Longtree‐Preciado, Stephanie Radhakishun, Wenhui Qiao, Na Zhao, Takashi Saito et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Propagation axonale des pathologies Tau et Aβ dans la maladie d'Alzheimer : à la recherche de propagons dans le circuit subiculo-fornico-mamillaireManon Thierry · 2020 · theses.fr (ABES)
- Étude du rôle de la microglie dans la propagation de la protéine Tau : mise en place de nouveaux modèlesCharlotte Duwat · 2021 · theses.fr (ABES)
- The Use of Localized Proteomics to Understand the Pathogenesis of Alzheimer's DiseaseGeoffrey Pires · 2021 · theses.fr (ABES)
- Étude de la forme sporadique de la maladie d'Alzheimer à partir de modèles in vivo et de neurones humains reprogrammésCamille Thiberge · 2023 · theses.fr (ABES)
- Using β-strand and β-hairpin peptidomimetics induced by constrained amino acids to modulate the aggregation of the microtubule associated protein Tau : design, synthesis and evaluationDavide Di Lorenzo · 2023 · theses.fr (ABES)
- Etude des mécanismes physiοpathοlοgiques de la maladie d'Alzheimer : appοrt de l'étude des variants du gène SΟRL1Romain Castelot · 2024 · theses.fr (ABES)
- Caractérisation et modulation du microbiote intestinal dans le contexte de la maladie d’Alzheimer : vers une nouvelle piste thérapeutiqueCaroline Ismeurt · 2021 · theses.fr (ABES)
- The Role of Tubulin Polyglutamylation in Controlling the Binding and Activity of Microtubule-Interacting ProteinsMariya Genova · 2023 · theses.fr (ABES)
- The light at the end of the tunnel : study of early-stage brain dynamics alterations in Alzheimer’s disease and beneficial effects of light stimulation in the AppNL-F/MAPT mouse modelMatthieu Aguilera · 2024 · theses.fr (ABES)
- Vertebrate Animal Models of Primary 4-Repeat TauopathiesDenglei Ma, Edward A. Burton · 2026 · Contemporary clinical neuroscience
- Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenograftsBart De Strooper, Jacqueline F. M. van Vierbergen, Sriram Balusu, Katrien Horré, Nóra Baligács, Dries T'svyen, Iordana Chrysidou, Annerieke S. R. Sierksma, Lutgarde Serneels, Dietmar Rudolf Thal et al. · 2026 · Research Square
- Robust tauopathy and memory deficits in a mouse model constitutively overexpressing human P301L MAPTMatthew J. Hamm, Kevin McNaught, Christopher Janus, Emely A. Gazarov, Zachary Strickland, Jessica Shubin, Jessica Reinhardt, Jinho Park, Sruti Rayaprolu, William V. Antropov et al. · 2026 · Neurobiology of Disease
- Amyloid exacerbates tau and alpha‐synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia modelBenjamin E. Rabichow, Lacey Nixon, Lauren Tallant, Katelin A. Gibson, David G. Nascari, J. Hudson Barnett, Nashali Massa, John Denis Fryer · 2026 · Alzheimer s & Dementia
- Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head InjuryRachel Furhang, Riley Morrone, Elena Nikulina, Mahdavi Jere, Ashmeet Kaur, Fizza Nayab, Takashi Saito, Takaomi C. Saido, Peter John Bergold · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Retinal manifestations of Alzheimer's Disease: Insights from animal models, clinical detection, and future translationXiayin Zhang, Dongli Zhuang, Chunran Lai, Chunwen Zheng, Zhi Da Soh, Siegfried K. Wagner, Vera Yuan Cai, Zhongwei Yang, Shan Wang, Xingchen Geng et al. · 2026 · Progress in Retinal and Eye Research
- Are mouse models of Alzheimer’s disease truly flawed, or are we misusing them?Frédéric Calon, Léa Otaegui, Mohamed Lala Bouali, Sébastien S. Hébert · 2026 · Neuroscience
- Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitabilityCayetana Arnaiz, Gonzalo Escalante, Lautaro Rodriguez Donghi, Mariana Inés Holubiec, Olivia Pedroncini, Indiana Páez Paz, Clara Gaguine, Julieta Bianchelli, Jordi Navarro, Micaela D. García et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Effect of tau silencing on tau pathology propagation, a treatment efficient at the earliest stages of the disease?Andreea‐Claudia Kosa, Lidia Lopez‐Gutierrez, Kunié Ando, Emilie Doeraene, Emmanuel Aydin, Hinde Lasri, Alain Wathelet‐Depauw, Karlien Pieters, David Van Morckhoven, Christine Dubois et al. · 2026 · Neurobiology of Disease
- Gene therapy in Alzheimer’s disease (AD)Maryam Bemanalizadeh, Mitra Ashrafi, Mahdieh Eslami, Shiva Moein, Asad Kazemi, Vahid Mansouri · 2026 · Elsevier eBooks
- Protein Quality Control Systems in Neurodegeneration—Chaperones, Cytoskeleton, and the Pathogenic Transition of TauAnjali Bisht, Srikanth Pippadpally, Vimlesh Kumar · 2026 · Molecular Neurobiology