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A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle
Open accessAbstract
Lysosomes are endocytic subcellular compartments that contribute to the degradation and recycling of cellular material. Using highly purified rat liver tritosomes (Triton WR1339-filled lysosomes) and an ion exchange chromatography/LC-tandem MS-based protein/peptide separation and identification procedure, we characterized the major integral membrane protein complement of this organelle. While many of the 215 proteins we identified have been previously associated with lysosomes and endosomes, others have been associated with the endoplasmic reticulum, Golgi, cytosol, plasma membrane, and lipid rafts. At least 20 proteins were identified as unknown cDNAs that have no orthologues of known function, and 35 proteins were identified that function in protein and vesicle trafficking. This latter group includes multiple Rab and SNARE proteins as well as ubiquitin. Defining the roles of these proteins in the lysosomal membrane will assist in elucidating novel lysosomal functions involved in cellular homeostasis and pathways that are affected in various disease processes.
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Cites
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685
Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase
Ueno, T., Ishidoh, K., Mineki, R., Tanida, I., Murayama, K., Kadowaki, M., & Kominami, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15222 · Cited by 50
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MacMicking, J. D. (2012) · Nature Reviews Immunology · doi:10.1038/nri3210 · Cited by 579
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Yang, C., & Wang, X. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102001 · Cited by 473
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Kneipp, J., Kneipp, H., McLaughlin, M., Brown, D., & Kneipp, K. (2006) · Nano Letters · doi:10.1021/nl061517x · Cited by 472
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Speers, A. E., & Wu, C. C. (2007) · Chemical Reviews · doi:10.1021/cr068286z · Cited by 325
Metadata
- Authors
- Bagshaw, R. D., Mahuran, D. J., & Callahan, J. W.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 4
- Issue
- 2
- Pages
- 133-143
- ISSN
- 1535-9476 (ISSN-L)
- OpenAlex
- W2150158059
- Cited by
- 175
- References
- 2
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bagshaw, R. D., Mahuran, D. J., & Callahan, J. W. (2005). A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle. Molecular & Cellular Proteomics. https://doi.org/10.1074/mcp.m400128-mcp200
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