The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Regulation of Protein Degradation by O-GlcNAcylation: Crosstalk with Ubiquitination
Open accessAbstract
The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, translation, and protein degradation. Misfolded, damaged, and unwanted proteins are tagged with a chain of ubiquitin moieties for degradation by the proteasome, which is critical for cellular homeostasis. In this review, we summarize the current knowledge of the interplay between O-GlcNAcylation and ubiquitination in the control of protein degradation. Understanding the mechanisms of action of O-GlcNAcylation in the ubiquitin-proteosome system shall facilitate the development of therapeutics for human diseases such as cancer, metabolic syndrome, and neurodegenerative diseases.
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Cites
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Deng, H.-X., Chen, W., Hong, S.-T., Boycott, K. M., Gorrie, G. H., Siddique, N., Yang, Y., Fecto, F., Shi, Y., Zhai, H., et al. (2011) · Nature · doi:10.1038/nature10353 · Cited by 1,174
linking metabolism to epigenetics through O-GlcNAcylation
Hanover, J. A., Krause, M. W., & Love, D. C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3334 · Cited by 414
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1
Machida, Y. J., Machida, Y., Vashisht, A. A., Wohlschlegel, J. A., & Dutta, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046755 · Cited by 274
Shukla, A., Chaurasia, P., & Bhaumik, S. R. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8605-1 · Cited by 98
Cited by
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan, H.-B., Dietrich, M. O., Liu, Z.-W., Zimmer, M. R., Li, M.-D., Singh, J. P., Zhang, K., Yin, R., Wu, J., Horvath, T. L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.010 · Cited by 281
Self-citationMass Spectrometry-Based Detection and Assignment of Protein Posttranslational Modifications
Doll, S., & Burlingame, A. L. (2015) · ACS Chemical Biology · doi:10.1021/cb500904b · Cited by 261
Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation
Ruan, H.-B., Ma, Y., Torres, S., Zhang, B., Feriod, C., Heck, R. M., Qian, K., Fu, M., Li, X., Nathanson, M. H., et al. (2017) · Genes & Development · doi:10.1101/gad.305441.117 · Cited by 151
Self-citationO-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains
Zhu, Y., Liu, T.-W., Cecioni, S., Eskandari, R., Zandberg, W. F., & Vocadlo, D. J. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1774 · Cited by 134
Mannino, M. P., & Hart, G. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828648 · Cited by 63
Metadata
- Authors
- Ruan, H.-B., Nie, Y., & Yang, X.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 12
- Issue
- 12
- Pages
- 3489-3497
- ISSN
- 1535-9476 (ISSN-L)
- OpenAlex
- W2120838039
- Cited by
- 185
- References
- 5
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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