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Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation
Abstract
Starvation induces liver autophagy, which is thought to provide nutrients for use by other organs and thereby maintain whole-body homeostasis. Here we demonstrate that O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is required for glucagon-stimulated liver autophagy and metabolic adaptation to starvation. Genetic ablation of OGT in mouse livers reduces autophagic flux and the production of glucose and ketone bodies. Upon glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase II (CaMKII) phosphorylates OGT, which in turn promotes O-GlcNAc modification and activation of Ulk proteins by potentiating AMPK-dependent phosphorylation. These findings uncover a signaling cascade by which starvation promotes autophagy through OGT phosphorylation and establish the importance of O-GlcNAc signaling in coupling liver autophagy to nutrient homeostasis.
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“Persulfidation (S-sulfhydration) plays an importal role in mitophagy-related proteins such as PRKN, whose catalytic activity is stimulated by persulfidation, whereas nitrosylation inactivates it [1007].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [1007]
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“BafA1 treatment further elevated the levels of LC3-II, suggesting that OGT promotes autophagic flux by activating early steps in autophagosome formation rather than by blocking autophagosome turnover at late stages (Klionsky et al. 2012).”
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BackgroundPARTICIPATION OF LYSOSOMES IN CELLULAR AUTOPHAGY INDUCED IN RAT LIVER BY GLUCAGON
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“In contrast, glucagon induces autophagy, yet the physiological function and the underlying molecular mechanisms of glucagon-regulated autophagy are ill defined (Deter et al. 1967; Arstila andTrump 1968; Schworer and Mortimore 1979).”
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Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
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Metadata
- Authors
- Ruan, H.-B., Ma, Y., Torres, S., Zhang, B., Feriod, C., Heck, R. M., Qian, K., Fu, M., Li, X., Nathanson, M. H., Bennett, A. M., Nie, Y., Ehrlich, B. E., & Yang, X.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-08-15
- Volume
- 31
- Issue
- 16
- Pages
- 1655-1665
- ISSN
- 0890-9369
- 1549-5477
- PMC
- PMC5647936
- Cited by
- 151
- References
- 10
- Language
- en
- Funders
- National Institutes of Health (R01DK089098, R01DK102648, CT DPH2014-0139)
- American Cancer Society
- Ellison Medical Foundation
- NIH (P01DK57751, P30DK34989)
- American Heart Association (14SDG20120052)
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