Myelinogenesis in the Optic Nerve of (C57BL � CBA) F1 Hybrid Mice: A Morphometric Analysis
Abstract
Myelinogenesis in the optic nerve of the mouse begins by the end of the first week of postnatal life and proceeds well into adulthood. The optic nerve from different postnatal age groups of (C57BL x CBA) F1 hybrid mice was analysed ultrastructurally and morphometrically. Features examined were the myelinated and unmyelinated nerve fibres, mean myelinated nerve fibre diameter, myelinated nerve fibre diameter spectrum, number of myelin sheath lamellae in relation to fibre diameter and age. Results obtained showed that the optic nerve of the mouse is populated entirely by unmyelinated nerve fibres at birth. Myelinogenesis begins at about the fifth postnatal day (pnd), with clearer evidence by the 6th pnd. It starts selectively with the largest fibres and then progresses to involve other fibres of decreasing diameter. After the onset, myelinogenesis progresses with increasing rapidity, becoming most intense from the second week up to the fifth week, so that by the end of the fifth week about 73% of fibres have become myelinated. From then onward, the process proceeds at a progressively diminishing rate until, by the 16th week, virtually all the remaining 27% fibres are myelinated. At onset, the myelin sheath is loosely wrapped around the axons, but with increasing age the myelin lamellae become more compact around the axons. The population of unmyelinated fibres continued to diminish so that at the completion of the process (16th week), they were only very rarely encountered. Myelinogenesis in the optic nerve of the mouse appears to follow a similar course to that seen in other central tracts having a similar fibre diameter spectrum.
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In the 4-month-old mouse optic nerve, practically all axons are already myelinated.
“We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Dangata and Kaufman, 1997
Myelination in the mouse optic nerve follows a similar course to the rat optic nerve.
“Myelination in the mouse optic nerve follows a similar course (Bartsch et al., 1997; Dangata et al., 1996; Dangata and Kaufman, 1997).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Dangata and Kaufman, 1997
In C57BL × CBA mice, practically all optic nerve axons were myelinated by P112.
“Reinforcing this, a study of C57BL × CBA mice (F1 generation), similar to the genetic background of our mice, found that “practically all” optic nerve axons were myelinated by P112 (Dangata et al., 1996; Dangata and Kaufman, 1997).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Dangata and Kaufman, 1997
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- Authors
- Dangata, Y. Y., & Kaufman, M. H.
- Affiliations
- University of Edinburgh (GB)
- ORCID
- Kaufman, M H
- Venue
- European Journal of Morphology
- Publisher
- Portico
- Published
- 1997-02-01
- Volume
- 35
- Issue
- 1
- Pages
- 3-18
- ISSN
- 0924-3860 (ISSN-L)
- OpenAlex
- W2009043254
- Cited by
- 42
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 5
- FWCI
- 0.22
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- European Journal of Morphology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- myelination, optic nerve, myelinated axons, unmyelinated nerve fibers, postnatal development, axonal myelination
- MeSH terms
- Aging, Animals, Mice, Inbred CBA, Mice, Inbred C57BL, Microscopy, Electron, Myelin Sheath, Optic Nerve, Image Cytometry, Mice
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