The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Regulation of virulence genes in Listeria
Abstract
As in all pathogenic bacteria, virulence of the facultative intracellular Listeria species is a multifactorial trait. The expression of the bacterial genes involved in the different steps of the infectious process--invasion, intracellular multiplication and spreading--is temporally and spatially controlled, thus ensuring the presence of the respective gene products at the right moment and place. So far, one network which is involved in the regulation of listerial virulence, the PrfA regulon, has been characterized rather well. The key element of this regulon, PrfA, belongs to the Crp/Fnr family of transcriptional regulators. Its synthesis and activity are influenced by a variety of physico-chemical signals outside and inside of eukaryotic host cells. The analysis of virulence gene expression in vivo, i.e. in infected host cells, indicates that yet uncharacterized bacterial factors other than PrfA, and possibly also host factors, modulate the expression of the PrfA regulon. Essentially nothing is known about the signal transduction pathways involved in the observed differential expression of virulence genes. Fermentable carbon sources seem to have a particular role in virulence gene regulation. In addition to the PrfA regulon, the Clp stress proteins have an impact on Listeria virulence. These two regulons interact with each other by an unknown mechanism.
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“It has been shown that expression of Fur is negatively regulated by PerR, a Fur homologue that is involved in the oxidative stress response.”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [57]
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“Fourteen Fur-regulated genes have been identified in L. monocytogenes, including genes that encode Fe2+ transporters and ferrichrome ABC transporters and proteins involved in Fe storage [56, 57].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [57]
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Metadata
- Authors
- Kreft, J., & Vázquez-Boland, J. A.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Kreft, Jürgen
- Venue
- International Journal of Medical Microbiology
- Publisher
- Elsevier BV
- Published
- 2001
- Volume
- 291
- Issue
- 2
- Pages
- 145-157
- ISSN
- 1438-4221 (ISSN-L)
- OpenAlex
- W2073528230
- Cited by
- 140
- References
- 80
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission (BMH4-CT96-0659)
- Deutsche Forschungsgemeinschaft (KR 1206/3-2)
- Dirección General de Enseñanza Superior e Investigación Científica (BMC2000-0553, DGESIC PB97-0327-C03-01)
- Verband der Chemischen Industrie
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Listeria monocytogenes in Food Safety
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Listeria, virulence gene regulation, intracellular bacterial pathogens, signal transduction, carbon source regulation, host-pathogen interaction
- MeSH terms
- Bacterial Proteins, Listeria monocytogenes, Peptide Termination Factors, Virulence, Trans-Activators, Gene Expression Regulation, Bacterial, Molecular Chaperones
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