The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transcription factor NF-κB as a potential biomarker for oxidative stress
Open accessAbstract
There is increasing interest in the involvement of transcription factors, such as of the transcription factor NF-kappaB (nuclear factor-kappaB), in the pathogenesis of various diseases. NF-kappaB is involved in the control of the transcription of a variety of cellular genes that regulate the inflammatory response by the production of cytokines, chemokines, cell adhesion molecules and acute phase proteins. The involvement of NF-kappaB is especially of interest as it is activated by oxidative stress and its activation can be modulated by antioxidant compounds. The activation of NF-kappaB can be determined by the electromobility shift assay (EMSA) with a NF-kappaB binding-site-specific probe. EMSA can also be used on human mononuclear cells isolated from peripheral blood, which could make the assay applicable for clinical trials. The critical steps of the EMSA are discussed, addressing some pitfalls of the assay. The procedure that can be used to express NF-kappaB activity in human subjects is evaluated. This offers the possibility to use NF-kappaB as a functional biomarker of oxidative stress as illustrated by several examples of in vitro and in vivo studies.
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Cites
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · cited 1×
“NF-kB also regulates the expression of inflammatory enzymes, including the inducible form of nitric oxide synthetase (iNOS) (Xie et al. 1994) and inducible cyclo-oxygenase (COX-II) (Crofford et al. 1997).”
BackgroundScheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819
van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.6.1714 · Cited by 144
Cited by
Cellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538
Molecular mechanisms of cell proliferation induced by low power laser irradiation
Gao, X., & Xing, D. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-4 · Cited by 507
Motojima, M., Hosokawa, A., Yamato, H., Muraki, T., & Yoshioka, T. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00906.x · Cited by 278
Esposito, G., De Filippis, D., Maiuri, M. C., De Stefano, D., Carnuccio, R., & Iuvone, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.047 · Cited by 225
van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.6.1714 · Cited by 144
Metadata
- Authors
- van den Berg, R., Haenen, G. R. M. M., van den Berg, H., & Bast, A.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2001-08
- Volume
- 86
- Issue
- S1
- Pages
- S121-S127
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2060991251
- Cited by
- 202
- References
- 3
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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