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Cited by 144Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers

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van den Berg, Robin, van Vliet, Trinette, Broekmans, Wendy M.R., Cnubben, Nicole H.P., Vaes, Wouter H.J., Roza, Len, Haenen, Guido R.M.M., Bast, Aalt +1 more·2001·The Journal of Nutrition
DOI 10.1093/jn/131.6.1714
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Abstract

The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments, was performed in a group of 22 male smokers with a relatively low vegetable and fruit intake using a vegetable burger and fruit drink. The vegetable burger and fruit drink increased serum levels of vitamin C, alpha-carotene, beta-carotene, beta-cryptoxanthin and zeaxanthin and plasma total antioxidant capacity. However, no effects were demonstrated on any marker of oxidative damage to lipids (malondialdehyde F(2)-isoprostane) proteins (carbonyls) and DNA (Comet assay) and (functional) markers of oxidative stress (reduced/oxidized glutathione ratio, glutathione-S-transferase alpha, glutathione-S-transferase pi and nuclear transcription factor-kappaB). Apparently, these increased levels of antioxidants in serum were not sufficiently high to show beneficial changes with the selected biomarkers. Alternatively, oxidative stress in male smokers with a relatively low fruit and vegetable intake might have been still too low to demonstrate a beneficial effect of antioxidants.

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Crossref · 10.1093/jn/131.6.1714

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  • Benefits of berry intervention were seen in healthy subjects and in those with existing metabolic risk factors.

    “Benefits were seen in healthy subjects and in those with existing metabolic risk factors.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]

  • Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (fresh, juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.

    “Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]

  • The most significant outcomes of clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.

    “The most significant outcomes of these clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]

  • Berries were shown to increase plasma antioxidant capacity and to decrease lipid peroxidation in smokers who are at high risk of developing CVD.

    “Berries were also shown to increase plasma antioxidant capacity36 and to decrease lipid peroxidation42 in smokers who are at high risk of developing CVD.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]

  • Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.

    “Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [36]

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2 of the 63 references couldn’t be matched to a known paper.

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  1. Van den Berg, R., Haenen, G.R.M.M., van den Berg, H. & Bast, A. (2001) Nuclear factor-B as a potential biomarker of oxidative stress. Br. J. Nutr. (in press).
  2. Hulshof, K.F.A.M., Kistenmaker, C., Bouwmans, M. & Lo ¨wik, M.R.H. (1998) Energy and nutrient intake of the Dutch population-Dutch Nutrition Surveillance System 1997-1998. TNO report V98.805 (in Dutch), pp. 1-13.

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Authors
van den Berg, R., van Vliet, T., Broekmans, W. M. R., Cnubben, N. H. P., Vaes, W. H. J., Roza, L., Haenen, G. R. M. M., Bast, A., & van den Berg, H.
Affiliations
Maastricht University (NL)
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2001-06
Volume
131
Issue
6
Pages
1714-1722
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/131.6.1714
OpenAlex
W2099422363
Cited by
144
References
63
Citations by year
2025: 1 · 2024: 1 · 2021: 3 · 2019: 3 · 2018: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 8
FWCI
6.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • TNO Repository (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
antioxidant status, oxidative stress, smokers, lipid peroxidation, protein carbonylation, DNA damage, glutathione, glutathione S-transferase, NF-κB, carotenoids, vitamin C, dietary supplementation
MeSH terms
Adult, Antioxidants, Blood Pressure, Body Weight, Carotenoids, Cholesterol, DNA Damage, Fruit, Humans, Cholesterol, HDL, Male, Malondialdehyde, Middle Aged, Monocytes, Smoking, Time Factors, Triglycerides, Vegetables, Vitamin A, Vitamin E, Oxidative Stress, Cross-Over Studies

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