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Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats
Open accessAbstract
The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.
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“There have also been reports on altered mitochondrial adaptations in skeletal muscle during the development of insulin resistance in adults (36, 37), as well as an improvement in mitochondrial capacity to oxidize fat-derived substrates and increase in number (38).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [36]
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Hartree, E. F. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90094-2 · Cited by 5,542
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
Estabrook, R. W. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10010-4 · Cited by 1,781
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887
Lee, Y., & Lardy, H. A. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97593-9 · Cited by 632
A Controlled High-Fat Diet Induces an Obese Syndrome in Rats
Woods, S. C., Seeley, R. J., Rushing, P. A., D’Alessio, D. A., & Tso, P. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.1081 · Cited by 539
The Function of Leptin in Nutrition, Weight, and Physiology
Friedman, J. M. (2002) · Nutrition Reviews · doi:10.1301/002966402320634878 · Cited by 510
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00024-x · Cited by 391
The energy cost of fat and protein deposition in the rat
Pullar, J. D., & Webster, A. J. F. (1977) · British Journal Of Nutrition · doi:10.1079/bjn19770039 · Cited by 382
Dietary Fat Intake and Regulation of Energy Balance: Implications for Obesity
Hill, J. O., Melanson, E. L., & WYATT, H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.284s · Cited by 318
Strain-Specific Response to 3-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice
Collins, S., Daniel, K. W., Petro, A. E., & Surwit, R. S. (1997) · Endocrinology · doi:10.1210/endo.138.1.4829 · Cited by 276
Jéquier, E. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802123 · Cited by 256
Leptin and Insulin Action in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2002) · Nutrition Reviews · doi:10.1301/002966402320634797 · Cited by 229
The Role of Leptin in the Control of Body Weight
Leibel, R. L. (2002) · Nutrition Reviews · doi:10.1301/002966402320634788 · Cited by 201
Thermogenesis and Thyroid Function
Freake, H. C., & Oppenheimer, J. H. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001403 · Cited by 177
Dietary Determinants of Energy Intake and Weight Regulation in Healthy Adults
McCrory, M. A., Fuss, P., Saltzman, E. J., & Roberts, S. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.276s · Cited by 172
Impaired leptin responsiveness in aged rats.
Scarpace, P. J., Matheny, M. E., Moore, R. L., & Tümer, N. (2000) · Diabetes · doi:10.2337/diabetes.49.3.431 · Cited by 154
The Impact of Nutrition on Thyroid Hormone Physiology and Action
Danforth, E., & Burger, A. (1989) · Annual Review of Nutrition · doi:10.1146/annurev.nu.09.070189.001221 · Cited by 151
Thyroid hormone action on intermediary metabolism
Müller, M. J., & Seitz, H. J. (1984) · Journal of Molecular Medicine · doi:10.1007/bf01725187 · Cited by 99
Skeletal muscle oxidative capacity in rats fed high-fat diet
Iossa, S., Mollica, M. P., Lionetti, L., Crescenzo, R., Botta, M., & Liverini, G. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801844 · Cited by 91
Self-citationBarzilai, N., & Rossetti, L. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.3.e591 · Cited by 85
Rothwell, N. J., & Stock, M. J. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014270 · Cited by 80
beta 3-Adrenergic-mediated suppression of leptin gene expression in rats
Li, H., Matheny, M. E., & Scarpace, P. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1031 · Cited by 73
Energy Intake and Utilization Vary During Development in Rats
Iossa, S., Lionetti, L., Mollica, M. P., Barletta, A., & Liverini, G. (1999) · Journal of Nutrition · doi:10.1093/jn/129.8.1593 · Cited by 64
Self-citationMetabolic response to a high-fat diet in neonatal and adult rat muscle
Nemeth, P. M., Rosser, B. W., Choksi, R. M., Norris, B. J., & Baker, K. M. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.2.c282 · Cited by 60
Rothwell, N. J., Stock, M. J., & Warwick, B. P. (1985) · Metabolism · doi:10.1016/0026-0495(85)90214-8 · Cited by 54
Tyzbir, R. S., Kunin, A. S., Sims, N. M., & Danforth, E. (1981) · Journal of Nutrition · doi:10.1093/jn/111.2.252 · Cited by 52
A Comparison of Methods for Determining Total Body Protein
Brooks, S. P. J., Lampi, B. J., Sarwar, G., & Botting, H. G. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1186 · Cited by 51
The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice
Evans, B. A., Agar, L., & Summers, R. J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00049-6 · Cited by 45
Effect of High-Fat Diet on Body Composition and Hormone Responses to Glucose Tolerance Tests
Brown, J. L., Spicer, M. T., & SPICER, L. J. (2002) · Endocrine · doi:10.1385/endo:19:3:327 · Cited by 37
β 3 -Adrenergic regulation of leptin, food intake, and adiposity is impaired with age
Kumar, M., Moore, R. L., & Scarpace, P. J. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900110 · Cited by 36
Induction of Thermogenic Enzymes by DHEA and Its Metabolites
Lardy, H. A., Kneer, N. M., Bellei, M., & Bobyleva, V. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17380.x · Cited by 30
Preferential Fat Intake Increases Adiposity but not Body Weight in Sprague-Dawley Rats
Smith, B. K., KELLY, L. A., PIÑA, R., York, D. A., & Bray, G. A. (1998) · Appetite · doi:10.1006/appe.1998.0162 · Cited by 25
Iossa, S., Mollica, M. P., Lionetti, L., Barletta, A., & Liverini, G. (1995) · PubMed · Cited by 24
Self-citationEnergy balance and liver respiratory activity in rats fed on an energy-dense diet
Iossa, S., Mollica, M. P., Lionetti, L., Barletta, A., & Liverini, G. (1997) · British Journal Of Nutrition · doi:10.1017/s0007114500002919 · Cited by 20
Self-citationMollica, M. P., Iossa, S., Liverini, G., & Soboll, S. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90260-3 · Cited by 19
Self-citationBobyleva, V., Pazienza, T. L., Muscatello, U., Kneer, N. M., & Lardy, H. A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1942 · Cited by 15
Hepatic Fatty Acid‐Supported Respiration in Rats Fed an Energy‐Dense Diet
Liverini, G., Iossa, S., Mollica, M. P., Lionetti, L., & Barletta, A. (1996) · Cell Biochemistry and Function · doi:10.1002/cbf.692 · Cited by 9
Self-citationFat balance and hepatic mitochondrial function in response to fat feeding in mature rats
Iossa, S., Lionetti, L., Mollica, M. P., Barletta, A., & Liverini, G. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801041 · Cited by 9
Self-citationIossa, S., Lionetti, L., Mollica, M. P., Crescenzo, R. M. D., Botta, M., & Liverini, G. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-15413 · Cited by 7
Self-citation
Research works printed but not linked: 1
- 1998, Obesity: Preventing and Managing the Global Epidemic
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Chen, Z., Tian, R., She, Z., Cai, J., & Li, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.025 · Cited by 1,340
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,284
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
Bough, K. J., Wetherington, J. P., Hassel, B., Paré, J., Gawryluk, J. W., Greene, J. G., Shaw, R. N., Smith, Y., Geiger, J. D., & Dingledine, R. J. (2006) · Annals of Neurology · doi:10.1002/ana.20899 · Cited by 605
Mitochondrial dysfunction and insulin resistance: an update
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Metadata
- Authors
- Iossa, S., Lionetti, L., Mollica, M. P., Crescenzo, R., Botta, M., Barletta, A., & Liverini, G.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Liverini, Giovanna
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-11
- Volume
- 90
- Issue
- 5
- Pages
- 953-960
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2155536232
- Cited by
- 120
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 1 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (COFIN-2002)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- high-fat diet, metabolic efficiency, mitochondrial oxidative capacity, leptin, leptin resistance, obesity, energy expenditure, energy intake, body composition, nutrient partitioning, hepatic metabolism, skeletal muscle metabolism, triiodothyronine, insulin, aging, dietary fat
- MeSH terms
- Animals, Blood Glucose, Body Composition, Dietary Fats, Energy Metabolism, Fatty Acids, Nonesterified, Insulin, Liver, Male, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Oxidation-Reduction, Triiodothyronine, Rats, Wistar, Muscle, Skeletal, Leptin, Rats
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