The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats
Open accessAbstract
The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.
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“There have also been reports on altered mitochondrial adaptations in skeletal muscle during the development of insulin resistance in adults (36, 37), as well as an improvement in mitochondrial capacity to oxidize fat-derived substrates and increase in number (38).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [36]
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Metadata
- Authors
- Iossa, S., Lionetti, L., Mollica, M. P., Crescenzo, R., Botta, M., Barletta, A., & Liverini, G.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Liverini, Giovanna
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-11
- Volume
- 90
- Issue
- 5
- Pages
- 953-960
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2155536232
- Cited by
- 120
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 1 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (COFIN-2002)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- high-fat diet, metabolic efficiency, mitochondrial oxidative capacity, leptin, leptin resistance, obesity, energy expenditure, energy intake, body composition, nutrient partitioning, hepatic metabolism, skeletal muscle metabolism, triiodothyronine, insulin, aging, dietary fat
- MeSH terms
- Animals, Blood Glucose, Body Composition, Dietary Fats, Energy Metabolism, Fatty Acids, Nonesterified, Insulin, Liver, Male, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Oxidation-Reduction, Triiodothyronine, Rats, Wistar, Muscle, Skeletal, Leptin, Rats
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