The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.
Fetal programming of cardiovascular function through exposure to maternal undernutrition
Open accessAbstract
A substantial and robust body of epidemiological evidence indicates that prenatal dietary experience may be a factor determining cardiovascular disease risk. Retrospective cohort studies indicate that low birth weight and disproportion at birth are powerful predictors of later disease risk. This prenatal influence on non-communicable disease in later life has been termed programming. Maternal nutritional status has been proposed to be the major programming influence on the developing fetus. The evidence from epidemiological studies of nutrition, fetal development and birth outcome is, however, often weak and inconclusive. The validity of the nutritional programming concept is highly dependent on experimental studies in animals. The feeding of low-protein diets in rat pregnancy results in perturbations in fetal growth and dimensions at birth. The offspring of rats fed low-protein diets exhibit a number of metabolic and physiological disturbances, and are consistently found to have high blood pressure from early postnatal life. This experimental model has been used to explore potential mechanisms of programming through which maternal diet may programme the cardiovascular function of the fetus. Indications from this work are that fetal exposure to maternally-derived glucocorticoids plays a key role in the programming mechanism. Secondary to this activity, the fetal hypothalamic–pituitary–adrenal axis may stimulate renin–angiotensin system activity, resulting in increased vascular resistance and hypertension.
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“Individuals whose gestation coincided with the famine exhibited increased susceptibility to obesity, insulin resistance, and cardiovascular disease in adulthood, strongly implicating fetal adaptive responses to nutrient scarcity in shaping lifelong disease risk [10,11].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [10]
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Cites
Glucose tolerance in adults after prenatal exposure to famine
Ravelli, A., van der Meulen, J., Michels, R., Osmond, C., Barker, D., Hales, C., & Bleker, O. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07244-9 · Cited by 1,606
Diet and Health: What Should We Eat?
Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008 · cited 1×
“As reviewed by Willett (1994), the consumption of a high-fat diet, low in starch and fibre, appears to substantially raise individual risk of cardio-vascular mortality.”
Mothers, Babies, and Disease in Later Life
Gillman, M. W. (1995) · BMJ · doi:10.1136/bmj.310.6971.68a · Cited by 880
Glucocorticoid exposure in utero: new model for adult hypertension
Benediktsson, R., Lindsay, R. S., Noble, J., Seckl, J. R., & Edwards, C. R. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)90138-7 · Cited by 862
Mothers, Babies and Disease in Later Life
Barker, D. J. P., & Barker, D. J. P. (1994) · Medical Entomology and Zoology · Cited by 860
PREMATURE DELIVERY OF FOETAL LAMBS INFUSED WITH GLUCOCORTICOIDS
LIGGINS, G. C. (1969) · Journal of Endocrinology · doi:10.1677/joe.0.0450515 · Cited by 817
Kwong, W. Y., Wild, A. E., Roberts, P., Willis, A. C., & Fleming, T. P. (2000) · Development · doi:10.1242/dev.127.19.4195 · Cited by 798
Langley‐Evans, S. C., & Jackson, A. A. (1994) · Clinical Science · doi:10.1042/cs0860217 · Cited by 688
Self-citationFetal growth and coronary heart disease in South India
Stein, C., Fall, C., Kumaran, K., Osmond, C., Barker, D. J. P., & Cox, V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04547-3 · Cited by 607
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Research works printed but not linked: 9
- Pickard, 1996, Altered insulin response to a glucose load in rats following exposure to a low protein diet in utero, Proceedings of the Nutrition Society, 55, 44A
- Dunn, 2001, Hypertension in the mouse following intrauterine exposure to a maternal low-protein diet, Proceedings of the Nutrition Society, 60, 51A
- Leon, 1999, Fetal Programming: Influences on Development and Disease in Later Life, 12
- Marchand, 2001, Programming of blood pressure and renal structure in rats exposed to nitrogen-supplemented maternal low protein diets, Proceedings of the Nutrition Society, 60, 139A
- Celsi, 1997, Inhibition of renal growth by prenatal dexamethasone and the programming of blood pressure in the offspring, Journal of the American Society for Nephrology, 8, A1360
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- Sherman RC (1999) The role of the renin-angiotensin system in the fetal programming of hypertension. PhD Thesis, University of Southampton.
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Items 201–203 of 203
Klibaner-Schiff, E., Rutherford, J. N., deMartelly, V. A., Lagardo, F., Gundling, W. E., Wildman, D. E., Lee, N. R., & Kuzawa, C. W. (2026) · American Journal of Human Biology · doi:10.1002/ajhb.70336
Gaspar, A. L. C. (2011) · Americanae (AECID Library)
Nutrition and Stress and the Developing Fetus
Armony-Sivan, R., & Eidelman, A. I. (2006) · Humana Press eBooks · doi:10.1385/1-59259-952-4:205
Metadata
- Authors
- Langley-Evans, S. C.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2001-11
- Volume
- 60
- Issue
- 4
- Pages
- 505-513
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2135897417
- Cited by
- 203
- References
- 94
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 15 · 2013: 9 · 2012: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- fetal programming, maternal undernutrition, cardiovascular risk, low birth weight, fetal growth restriction, prenatal nutrition, low-protein diet, hypertension, glucocorticoids, hypothalamic-pituitary-adrenal axis, renin-angiotensin system, vascular resistance
- MeSH terms
- Animals, Birth Weight, Cardiovascular Diseases, Disease Models, Animal, Female, Glucocorticoids, Humans, Hypertension, Kidney, Nutrition Disorders, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Renin-Angiotensin System, Risk Factors, Rats
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