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The Lipid Organisation in the Skin Barrier
Open accessAbstract
The main function of the skin is to protect the body against exogenous substances. The skin barrier is located in the outermost layer of the skin, the stratum corneum. This layer consists of keratin enriched cells embedded in lipid lamellae. These lamellae form the main barrier for diffusion of substances through the skin. In diseased skin the barrier function is often impaired. For a full understanding of the properties of the human skin barrier, insight in the stratum corneum lipid organisation is of great importance. In this paper a short description of the lipid organisation in normal human stratum corneum will be given, after which the role the main lipid classes play in the stratum corneum lipid organisation will be described. In addition the effect of cholesterol sulfate and calcium on the lipid organisation will be discussed. Finally a new model, the "sandwich model", will be proposed that describe the localisation of the fluid phases in the stratum corneum.
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Citations
Cited by
The skin barrier in healthy and diseased state
Bouwstra, J. A., & Ponec, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.021 · Cited by 666
Overcoming the Stratum Corneum: The Modulation of Skin Penetration
Trommer, H., & Neubert, R. H. H. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000091978 · Cited by 572
The important role of stratum corneum lipids for the cutaneous barrier function
van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549
Vesicles as a tool for transdermal and dermal delivery
Honeywell-Nguyen, P. L., & Bouwstra, J. A. (2005) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2005.05.003 · Cited by 365
Water relations of tetrapod integument
Lillywhite, H. B. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02007 · Cited by 326
Metadata
- Authors
- A. Bouwstra, F. E. R. D.
- Venue
- Acta Dermato-Venereologica
- Publisher
- Medical Journals Sweden AB
- Published
- 2000-05-10
- Volume
- 80
- Issue
- 0
- Pages
- 23-30
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2108863057
- Cited by
- 191
- References
- 0
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
