The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Clinician-Assisted Internet-Based Treatment is Effective for Generalized Anxiety Disorder: Randomized Controlled Trial
Abstract
Objective: The aim of the present study was to determine the efficacy of an Internet-based clinician-assisted computerized cognitive behavioural treatment (CaCCBT) programme for generalized anxiety disorder (the Worry programme). Methods: Forty-eight individuals meeting diagnostic criteria for generalized anxiety disorder (GAD) were randomly assigned to the Worry programme or to a waitlist control group. In the clinician-assisted Worry programme, participants complete six online lessons, weekly homework assignments, receive weekly email contact from a clinical psychologist, and contribute to a moderated online discussion forum with other participants. An intention-to-treat model was used for data analyses. The main outcome measures were Generalized Anxiety Disorder–7 Item Scale (GAD-7) and the Penn State Worry Questionnaire (PSWQ). Results: A total of 75% of treatment group participants completed all six lessons within the 9 week programme and post-treatment data were collected from 21/24 treatment group and 19/21 control group participants. Treatment group participants reported significantly reduced symptoms of worry as measured on the GAD-7 and PSWQ and reduced symptoms of depression as measured on the Patient Health Questionnaire–9 Item Scale (PHQ-9). Mean within- and between-groups effect sizes (Cohen's d) across the two measures of GAD were 1.3 and 1.1, respectively. Participants found the treatment programme acceptable and satisfactory. The clinician spent a total mean of 130 min per person over the programme. Conclusions: The Worry programme, the first randomized controlled trial of CaCCBT for GAD, resulted in clinically significant improvements. These results are consistent with literature indicating that Internet-based programmes, when combined with clinical guidance, can significantly reduce the symptoms of common mental disorders.
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In the citing paper
“Previous ICBT studies on GAD indicate that ICBT can be effective.”
From Internet-delivered acceptance-based behavior therapy for generalized anxiety disorder: A pilot study (2016) · cites this paper as Titov et al., 2009
In the citing paper
“a number of studies have investigated the potential for internet-delivered treatments for GAD and they have reported significant post-treatment and follow-up gains [33,48-51] similar to those found in face-to-face treatment studies [52].”
From Low-intensity internet-delivered treatment for generalized anxiety symptoms in routine care: protocol for a randomized controlled trial (2014) · cites this paper as [51]
In the citing paper
“However, only a handful of studies have investigated the efficacy and effectiveness of low-intensity internet-delivered treatments for GAD [33,48-51].”
From Low-intensity internet-delivered treatment for generalized anxiety symptoms in routine care: protocol for a randomized controlled trial (2014) · cites this paper as [51]
Citations
Cites
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
KESSLER, R. C., ANDREWS, G., COLPE, L. J., HIRIPI, E., MROCZEK, D. K., NORMAND, S.-L. T., WALTERS, E. E., & ZASLAVSKY, A. M. (2002) · Psychological Medicine · doi:10.1017/s0033291702006074 · Cited by 10,327
Self-citationDevelopment and validation of the Penn State Worry Questionnaire
Meyer, T. J., Miller, M. L., Metzger, R. L., & Borkovec, T. D. (1990) · Behaviour Research and Therapy · doi:10.1016/0005-7967(90)90135-6 · Cited by 5,099 · cited 13×
“Univariate ANCOVAs on post-treatment GAD-7 and PSWQ scores, controlling for pre-treatment scores (Table 1), showed that the treatment group had significantly lower post-treatment scores than the control group (F1,42 27.38, p B 0.001; F1,42 12.89, p B 0.001), respectively.”
MethodInfluentialLöwe, B., Decker, O., Müller, S., Brähler, E., Schellberg, D., Herzog, W., & Herzberg, P. Y. (2008) · Medical Care · doi:10.1097/mlr.0b013e318160d093 · Cited by 4,527
Moher, D. (2001) · JAMA · doi:10.1001/jama.285.15.1987 · Cited by 2,545
Psychometric properties of the credibility/expectancy questionnaire
Devilly, G. J., & Borkovec, T. D. (2000) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/s0005-7916(00)00012-4 · Cited by 2,295 · cited 7×
“Pre-treatment expectancies and treatment satisfaction Pre-treatment expectancies, as measured on the expectancy factors from the CEQ, were not significantly correlated with any of the outcome measure change scores.”
BackgroundMethodInfluentialInternet-based cognitive behaviour therapy for symptoms of depression and anxiety: A meta-analysis
SPEK, V., CUIJPERS, P., NYKLÍČEK, I., RIPER, H., KEYZER, J., & POP, V. (2007) · Psychological Medicine · doi:10.1017/s0033291706008944 · Cited by 1,586
Research works printed but not linked: 2
- Lang AJ, 2004, J Clin Psychiatry, 65, 14
- Sheehan DV, 1998, J Clin Psychiatry, 59, 22
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Skaczkowski, G., van der Kruk, S., Loxton, S., Hughes-Barton, D., Howell, C., Turnbull, D., Jensen, N., Smout, M., & Gunn, K. (2022) · JMIR Mental Health · doi:10.2196/31018 · Cited by 9
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Akkol-Solakoglu, S., Hevey, D., & Richards, D. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100367 · Cited by 8
Online intervention for couples affected by generalized anxiety disorder
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Considerations in Art E-therapy for Anxiety Disorders
(2014) · Journal of Depression & Anxiety · doi:10.4172/2167-1044.1000170 · Cited by 7
“Similarly, Robinson, Titov, Andrews, McIntyre, Schwencke, and Solley [19], found no significant difference between clinician-assisted and technicianassisted versions of their online CBT program for generalized anxiety disorder.”
BackgroundMethodICBT in Psychiatry: Generalised Anxiety Disorder
Titov, N., Andersson, G., & Paxling, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-06083-5_5 · Cited by 7
Self-citationShiri, R., Varje, P., & Toppinen‐Tanner, S. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112140 · Cited by 6
Connors, J. D. N., Kroenke, K., Monahan, P. O., Chernyak, Y., Pettit, K., Hayden, J., Montgomery, C., Brenner, G., Millard, M., Holmes, E., et al. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.107020 · Cited by 6
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“G*power 3.1 was used to determine the number of subjects needed to achieve a power of 80%, significance level of 0.05, and effect size of 0.4, where these levels were set based on previous research [15].”
MethodInfluentialBert, F., Moro, G. L., Giacomini, G., Minutiello, E., & Siliquini, R. (2023) · Health Promotion International · doi:10.1093/heapro/daad006 · Cited by 5
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Titov, N., Dear, B. F., & Andersson, G. (2014) · Focus · doi:10.1176/appi.focus.12.3.299 · Cited by 5
Self-citationDahlin, M. (2020) · Linköping studies in behavioural science · doi:10.3384/diss.diva-170049 · Cited by 5
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Song, H., & Lee, K. (2022) · Children · doi:10.3390/children9101548 · Cited by 6
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BackgroundMethodTownsend, A. N., Hertz, A. G., D’Souza, J. M., & Wiese, A. D. (2022) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2022.05.003 · Cited by 4
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Andersson, G. (2014) · Wiley eBooks · doi:10.1002/9781118775349.ch61 · Cited by 3
Vernmark, K. (2017) · doi:10.3384/diss.diva-142389 · Cited by 3
“It has good psychometric properties and has been used in previous ICBT studies (Titov et al., 2009).”
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Basile, V. T., Newton-John, T. R. O., McDonald, S., & Wootton, B. M. (2024) · British Journal of Clinical Psychology · doi:10.1111/bjc.12516 · Cited by 2
Connors, J. D. N., Magalhaes, E., Prather, K., Khan, N., Draucker, C. B., Eliacin, J., Montgomery, C., Hayden, J., Millard, M., Kroenke, K., et al. (2025) · Journal of Patient Experience · doi:10.1177/23743735241310322 · Cited by 2
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Baños, R., Vara, M. D., Mira, A., García‐Palacios, A., & Botella, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00008-x · Cited by 2
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Maher, A. R., Apaydin, E. A., Raaen, L. B., Motala, A., Shanman, R., & Hempel, S. (2019) · RAND Corporation eBooks · doi:10.7249/rr2177 · Cited by 2
Wright, J. H., Chan, S. R., & Mishkind, M. C. (2022) · Springer eBooks · doi:10.1007/978-3-031-11984-2_9 · Cited by 1
Ulatowska, J. (2020) · Wydawnictwo Liberi Libri eBooks · doi:10.47943/lib.9788363487430.rozdzial18 · Cited by 21
Internet-delivered treatments for generalized anxiety disorder
Paxling, B. (2011) · Pure Amsterdam UMC · Cited by 1
Design Principles for Data Export : Action Design Research in U-CARE
Mustafa, M. I. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Lubin, R. E., Jordan, A., Wortmann, J. H., Larson, J. L., & Litz, B. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397045-9.00191-9
Lewis, C., Pearce, J., & Bisson, J. I. (2013)
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Östman, G., & Roch-Norlund, P. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Romijn, G., Batelaan, N. M., Kok, R., Koning, J., van Balkom, A. J. L. M., Titov, N., & Riper, H. M. (2018) · doi:10.2196/preprints.11706
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Isnawati, I., Widyastuti, W., & Ridfah, A. (2023) · Jurnal RAP (Riset Aktual Psikologi Universitas Negeri Padang) · doi:10.24036/rapun.v14i1.114464
Tang, S., Mahoney, A., Dobinson, K. A., & Shiner, C. T. (2025) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2025.2465737
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Metadata
- Authors
- Titov, N., Andrews, G., Robinson, E., Schwencke, G., Johnston, L., Solley, K., & Choi, I.
- Affiliations
- UNSW Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- Corresponding author
- Titov, Nickolai
- Venue
- Australian & New Zealand Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2009-01-01
- Volume
- 43
- Issue
- 10
- Pages
- 905-912
- ISSN
- 0004-8674 (ISSN-L)
- 1440-1614
- OpenAlex
- W2102373238
- Semantic Scholar
- 0c00964dd9a9544f82e95160878f9726632ce6dc
- Cited by
- 147
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 14 · 2014: 12 · 2013: 13 · 2012: 13
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian & New Zealand Journal of Psychiatry (publishedVersion)
- Funders
- Australian Rotary Health
- University of New South Wales
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- generalized anxiety disorder, online therapy, worry, depression, treatment acceptability
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