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Cited by 15Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents

Odds, F.C., Cheesman, S.L., Abbott, A.B.·1985·Medical Mycology
DOI 10.1080/00362178585380611
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Abstract

Several antifungal agents, at concentrations of 10 micrograms/ml, were shown to suppress ATP concentrations very rapidly in intact cells and spheroplasts of Candida albicans. The highest ATP-suppressing activity was shown by the highly lipophilic imidazole derivatives difonazole, clotrimazole, econazole, isoconazole, miconazole, oxiconazole and tioconazole, which all caused a reduction of cellular ATP content of more than 50% in 10 min. Relatively hydrophilic imidazole derivatives such as ketoconazole were essentially inactive in the test, as were the triazole derivatives fluconazole, ICI 153066, itraconazole and terconazole, and 5-fluorocytosine. Amphotericin B and terbinafine possessed intermediate ATP-suppressing activity, and the dose-response and pH-response curves for these compounds suggested their mechanism of ATP suppression differed from that of the active imidazole derivatives. ATP suppression by azole antifungals did not involve leakage of ATP from the cells and the effect was entirely abrogated by the presence of serum. Intact cells and spheroplasts of yeast-form and hyphal-form C. albicans were generally equally sensitive to ATP suppression, but stationary-phase cells of both morphological forms were less sensitive than exponential-phase cells. The extent of ATP suppression was significantly reduced in stationary-phase yeast cells of a C. albicans strain with known resistance to azole antifungals, but exponential-phase cells of resistant and susceptible strains were equally sensitive. The effect is tentatively ascribed to membrane damage caused directly by the antifungals.

Overview

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Registry

Crossref · 10.1080/00362178585380611

Cites

23 of 23 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 5

  1. Cope J.E, 1980, Journal of General Microbiology, 119, 245
  2. Davies A.R., 1981, Microbios Letters, 17, 155
  3. Marriott M.S, 1980, Journal of General Microbiology, 117, 253
  4. Vanden Bossche H., 1982, Archives Internationales de Physiologie et Biochemie, 90, B218
  5. Vanden Bossche H., 1984, Mode of Action of Antifungal Agents, 321

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Metadata

Authors
Odds, F. C., Cheesman, S. L., & Abbott, A. B.
Affiliations
University of Leicester (GB)
Venue
Medical Mycology
Publisher
Oxford University Press (OUP)
Published
1985-01
Volume
23
Issue
6
Pages
415-424
ISSN
  • 0268-1218 (ISSN-L)
  • 1369-3786
  • 1460-2709
DOI
10.1080/00362178585380611
OpenAlex
W4301119260
Cited by
15
References
23
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2019: 1 · 2013: 1
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Locations
  • Medical Mycology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed
Funders
Pfizer
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords
Candida albicans, imidazole antifungals, azole antifungals, clotrimazole, econazole, isoconazole, miconazole, oxiconazole, tioconazole, ketoconazole, triazole antifungals, fluconazole, itraconazole, terconazole, 5-fluorocytosine, amphotericin B, terbinafine, spheroplasts, membrane damage, azole resistance, serum protection
MeSH terms
Terbinafine, Adenosine Triphosphate, Amphotericin B, Antifungal Agents, Candida albicans, Depression, Chemical, Imidazoles, Ketoconazole, Miconazole, Naphthalenes

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