Bile acid metabolism and plasma protein turnover in Crohn’s disease
Abstract
Postprandial duodenal bile acids, intestinal protein loss, and albumin and IgG turnover were studied in 19 non-operated patients with Crohn's disease. A lesion of the terminal ileum was present in 18 of 19 patients, either alone or associated with regional colitis. Identical bile acid studies were made in a control group of 20 patients with chronic diarrhoea of undetermined origin. Duodenal bile acid concentration was decreased in 9 of 19 patients with Crohn's disease, and in 5 of 20 patients with unexplained diarrhoea. The glycine/taurine-ratio was increased in 8 of 17 patients with Crohn's disease, but in only one of the 20 control patients. Abnormal intestinal protein loss was present in 13 of 14 patients with Crohn's disease. The fractional catabolic rate of albumin and IgG was increased in all 17 cases of Crohn's disease studied, except the patient with no protein loss. A statistically significant and positive correlation was observed between glycine/taurine-ratio and fractional catabolic rate of both albumin and IgG. No patient with Crohn's disease harboured an abnormal bacterial flora in the proximal small intestine. It is concluded that, in the absence of abnormal bacterial flora in the proximal jejunum, the glycine/taurine-ratio is more valuable as an indicator of terminal ileopathy than postprandial duodenal bile acid concentration in nonoperated patients with terminal ileitis. Abnormal intestinal protein loss and increased catabolic rate of albumin and IgG are practically always present in active Crohn's disease and are strong evidence of an organic gastrointestinal lesion in patients with normal radiographic findings.
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Changes in bile acid pool composition, increased colonic GPBAR1 expression, and decreased ileal BAR activity have been detected in IBD patients.
“changes in the composition of the bile acid pool, an increase in colonic expression of GPBAR1 and a decrease in ileal activity of BAR have all been detected in patients suffering from IBD (Cipriani et al., 2011; Duboc et al., 2013; Lenz et al., 1976; Nijmeijer et al., 2011; Rutgeerts et al., 1979).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Lenz et al., 1976
Cites
Serum Orosomucoid in Ulcerative Colitis
Jensen, K. B., Jarnum, S., Koudahl, G., et al. (1976) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1976.12097092 · Cited by 65 · see citing works
Self-citationJarnum, S., & Jensen, K. B. (1972) · Gut · doi:10.1136/gut.13.2.128 · Cited by 52 · see citing works
Self-citationDanø, P., Lenz, K., & Justesen, T. (1974) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1974.12096910 · Cited by 50 · see citing works
Self-citationQuantitation of Gastrointestinal Protein Loss by Means of Fe59-Labeled Iron Dextran
Jarnum, S., Westergaard, H., YSSING, M., et al. (1968) · Gastroenterology · doi:10.1016/s0016-5085(19)34074-0 · Cited by 46 · see citing works
Self-citationvan Tongeren, J. H. M., & Reichert, W. J. (1966) · Clinica Chimica Acta · doi:10.1016/0009-8981(66)90062-3 · Cited by 41 · see citing works
Lenz, K. (1975) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1975.12096958 · Cited by 30 · see citing works
Self-citationJarnum, S., & Jensen, K. B. (1975) · Gastroenterology · doi:10.1016/s0016-5085(75)80129-6 · Cited by 21 · see citing works
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Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
- Authors
- Lenz, K., Jensen, K. B., & Jarnum, S.
- Affiliations
- Rigshospitalet (DK)
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1976-11-01
- Volume
- 11
- Issue
- 7
- Pages
- 721-727
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2462812329
- Cited by
- 9
- References
- 7
- Citations by year
- 2020: 3 · 2018: 1 · 2017: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Crohn's disease, bile acid metabolism, intestinal protein loss, albumin turnover, fractional catabolic rate, terminal ileitis, terminal ileum, bacterial flora, chronic diarrhea
- MeSH terms
- Adolescent, Adult, Bile Acids and Salts, Blood Proteins, Child, Crohn Disease, Diarrhea, Duodenum, Female, Glycine, Humans, Immunoglobulin G, Male, Middle Aged, Taurine
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