Pilot Study of Lorazepam and Tiagabine Effects on Sleep, Motor Learning, and Impulsivity in Cocaine Abstinence
Abstract
Objectives To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine. Methods We examined the effects of lorazepam and tiagabine on polysomnographically measured sleep and cognition in six cocaine dependent persons. Participants were studied during the first and second week of controlled abstinence following intravenous, laboratory cocaine administration. Results Lorazepam and tiagabine decreased sleep latency, but whereas lorazepam markedly increased light sleep, tiagabine caused a dramatic shift toward slow-wave sleep. Despite increasing total sleep time, lorazepam impaired sleep dependent learning and increased next day impulsivity. Conclusions These results introduce the possibility of different, sleep-related cognitive effects of mechanistically distinct GABAergic sedative hypnotics.
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Triazolam and zolpidem impair sleep-dependent consolidation of finger sequence tapping skills in humans.
“Two more recent studies in humans showed similarly impairing effects of triazolam and zolpidem on sleep-dependent consolidation of finger sequence tapping skills (835,836).”
From About Sleep's Role in Memory (2013) · cites this paper as [836]
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Sleep-dependent motor memory plasticity in the human brain
Walker, M. P., Stickgold, R., Alsop, D., Gaab, N., & Schlaug, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.007 · Cited by 308 · see citing works
Aharonovich, E. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00092-9 · Cited by 300 · see citing works
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- Morgan, P. T., & Malison, R. T.
- Affiliations
- Yale University (US)
- Venue
- The American Journal of Drug and Alcohol Abuse
- Publisher
- Informa UK Limited
- Published
- 2008-01-01
- Volume
- 34
- Issue
- 6
- Pages
- 692-702
- ISSN
- 0095-2990 (ISSN-L)
- 1097-9891
- OpenAlex
- W2154553716
- Cited by
- 32
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Drug and Alcohol Abuse (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA011744)
- National Center for Research Resources (KL2RR024138)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- lorazepam, tiagabine, cocaine abstinence, cocaine dependence, sleep, sleep latency, slow-wave sleep, sleep-dependent learning, impulsivity, cognitive impairment, polysomnography
- MeSH terms
- Tiagabine, Adult, Cognition Disorders, Female, Humans, Disruptive, Impulse Control, and Conduct Disorders, Sleep Initiation and Maintenance Disorders, Learning, Lorazepam, Male, Middle Aged, Nipecotic Acids, Pilot Projects, Polysomnography, GABA Agonists, GABA Modulators, Cocaine-Related Disorders
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