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ORGANOCHLORINE INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S DISEASE
Abstract
The concentrations of organochlorine (OC) compounds in the substantia nigra (SN) were compared in Parkinson's disease (PD) with concentrations in brain from cortical Lewy body dementia (CLBD), Alzheimer's disease (AD), and nondemented nonparkinsonian controls (CON). The levels of the gamma isomer of hexachlorocyclohexane (gammaHCH, lindane) were significantly higher in PD tissues (mean +/- SD: 0.56 +/- 0.434 microg/g lipid) than in the other three groups (CLBD 0.052 +/- 0.101 microg/g lipid; AD none detected; CON 0.125 +/- 0.195; all differences from PD significant at p < .05, Mann-Whitney U-test). Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1,1'-(2,2-dichloroethenyl diene)-bis(4-chlorobenzene) (p,p-DDE) and total Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD substantia nigra when these concentrations were compared with those of CLBD. These findings are not inconsistent with the hypothesis derived from epidemiological work and animal studies that organochlorine insecticides produce a direct toxic action on the dopaminergic tracts of the substantia nigra and may contribute to the development of PD in those rendered susceptible by virtue of cytochrome P-450 polymorphism, excessive exposure, or other factors.
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Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Cited by
The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Epidemiology and etiology of Parkinson's disease: a review of the evidence
Wirdefeldt, K., Adami, H.-O., Cole, P., Trichopoulos, D., & Mandel, J. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9581-6 · Cited by 1,199
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
Kortekaas, R., Leenders, K. L., van Oostrom, J. C. H., Vaalburg, W., Bart, J., Willemsen, A. T. M., & Hendrikse, N. H. (2005) · Annals of Neurology · doi:10.1002/ana.20369 · Cited by 733
Padhye, L. P., Srivastava, P., Jasemizad, T., Bolan, S., Hou, D., Shaheen, S. M., Rinklebe, J., O’Connor, D., Lamb, D., Wang, H., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131575 · Cited by 198
Cho, H.-S., Kim, S., Lee, S.-Y., Park, J. A., Kim, S.-J., & Chun, H. S. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.03.004 · Cited by 138
Metadata
- Authors
- F.M. Corrigan, C. L. W.
- Venue
- Journal of Toxicology and Environmental Health, Part A
- Publisher
- Informa UK Limited
- Published
- 2000-02-25
- Volume
- 59
- Issue
- 4
- Pages
- 229-234
- ISSN
- 0098-4108 (ISSN-L)
- 1528-7394
- 1087-2620
- OpenAlex
- W2133800815
- Cited by
- 251
- References
- 2
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: ORGANOCHLORINE INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S DISEASE. https://app.cochat.ai/papers/10.1080/009841000156907
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- F.M. Corrigan, C. L. W. (2000). ORGANOCHLORINE INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S DISEASE. Journal of Toxicology and Environmental Health, Part A. https://doi.org/10.1080/009841000156907
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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