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The protective effect of natural compounds against rotenone‐induced neurotoxicity

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l ‐Theanine Ameliorates d ‐Galactose‐Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways

Zeng, L., Lin, L., Chen, L., Xiao, W., & Gong, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8850112 · Cited by 41 · see citing works

The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats

Habib, C. N., Mohamed, M. R., Tadros, M. G., Tolba, M. F., Menze, E. T., & Masoud, S. I. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174573 · Cited by 41 · see citing works

l-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain

Sumathi, T., Asha, D., Nagarajan, G., Sreenivas, A., & Nivedha, R. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.01.008 · Cited by 40 · see citing works

Chronic Oral Epigallocatechin-gallate Alleviates Streptozotocin-induced Diabetic Neuropathic Hyperalgesia in Rat: Involvement of Oxidative Stress.

Baluchnejadmojarad, T., & Roghani, M. (2012) · Europe PMC (PubMed Central) · Cited by 40 · see citing works

Neuroprotective effects of oolong tea extracts against glutamate-induced toxicity in cultured neuronal cells and β-amyloid-induced toxicity in Caenorhabditis elegans

Zhang, S., Duangjan, C., Tencomnao, T., Liu, J., Lin, J., & Wink, M. (2020) · Food & Function · doi:10.1039/d0fo01072c · Cited by 39 · see citing works

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Xu, J., Wei, Y., Huang, Y., & Wei, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c07702 · Cited by 38 · see citing works

Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits

Dutta, D., & Mohanakumar, K. P. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.005 · Cited by 38 · see citing works

Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases

Hügel, H., & Jackson, N. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712800493906 · Cited by 34 · see citing works

Protective Effect of Epigallocatechin Gallate in Murine Water‐Immersion Stress Model of Chronic Fatigue Syndrome

Sachdeva, A. K., Kuhad, A., Tiwari, V., Arora, V. K., & Chopra, K. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00525.x · Cited by 33 · see citing works

Stuck at the bench: Potential natural neuroprotective compounds for concussion

Petraglia, A. L., Bailes, J., & Winkler, E. (2011) · Surgical Neurology International · doi:10.4103/2152-7806.85987 · Cited by 33 · see citing works

Health Benefits of Theanine in Green Tea: A Review

Liang, Y.-R., Liu, C., Xiang, L.-P., & Zheng, X.-Q. (2015) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v14i10.29 · Cited by 31 · see citing works

Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory

Tamano, H., Fukura, K., Suzuki, M., Sakamoto, K., Yokogoshi, H., & Takeda, A. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.02.005 · Cited by 33 · see citing works

Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients

Miodownik, C., Maayan, R., Ratner, Y., Lerner, V., Pintov, L., Mar, M., Weizman, A., & Ritsner, M. S. (2011) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e318220d8c6 · Cited by 31 · see citing works

l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes

Takeshima, M., Miyazaki, I., Murakami, S., Kita, T., & Asanuma, M. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.16-15 · Cited by 31 · see citing works

L-Theanine Protects H9C2 Cells from Hydrogen Peroxide-Induced Apoptosis by Enhancing Antioxidant Capability

Li, C., Yan, Q., Tang, S., Xiao, W., & Tan, Z. (2018) · Medical Science Monitor · doi:10.12659/msm.907660 · Cited by 32 · see citing works

l-Theanine promotes cultured human Sertoli cells proliferation and modulates glucose metabolism

Dias, T. R., Bernardino, R. L., Alves, M. G., Silva, J., Barros, A., Sousa, M., Casal, S. I. P., Silva, B. M., & Oliveira, P. F. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01999-2 · Cited by 29 · see citing works

Pioglitazone Attenuates Lipopolysaccharide-Induced Oxidative Stress, Dopaminergic Neuronal Loss and Neurobehavioral Impairment by Activating Nrf2/ARE/HO-1

Zakaria, A., Rady, M., Mahran, L., & Abou‐Aisha, K. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02907-0 · Cited by 28 · see citing works

Theanine attenuates hippocampus damage of rat cerebral ischemia-reperfusion injury by inhibiting HO-1 expression and activating ERK1/2 pathway

Zhao, J., Zhao, X., Tian, J., Xue, R., Luo, B., Lv, J., Gao, J., & Wang, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117160 · Cited by 28 · see citing works

Protective effect of plant compounds in pesticides toxicity

Jabłońska‐Trypuć, A., & Wiater, J. (2022) · Journal of Environmental Health Science and Engineering · doi:10.1007/s40201-022-00823-0 · Cited by 30 · see citing works

Comparison of Azorean tea theanine to teas from other origins by HPLC/DAD/FD. Effect of fermentation, drying temperature, drying time and shoot maturity

Baptista, J., Lima, E., Paiva, L. S., Andrade, A. L., & Alves, M. G. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.050 · Cited by 28 · see citing works

Inhibition by microbial metabolites of Chinese dark tea of age-related neurodegenerative disorders in senescence-accelerated mouse prone 8 (SAMP8) mice

Cai, S., Heng, Y., Wen, B., Zhu, K., Zheng, X., Huang, J., Wang, Y., Liu, Z., & Tu, P. (2018) · Food & Function · doi:10.1039/c8fo01512k · Cited by 28 · see citing works

Natural antioxidants in the management of Parkinson’s disease: Review of evidence from cell line and animal models

Abdul-Latif, R., Stupans, I., Allahham, A., Adhikari, B., & Thrimawithana, T. R. (2021) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2021.03.007 · Cited by 27 · see citing works

Mitochondrial Dysfunction Precedes Other Sub-Cellular Abnormalities in an In Vitro Model Linked with Cell Death in Parkinson’s Disease

Yong-Kee, C. J., Sidorova, E. S., Hanif, A., Perera, G., & Nash, J. E. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9259-6 · Cited by 27 · see citing works

Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia–reperfusion injury in rats

Sun, L., Xia, T., Gou, L., Ling, X., Wang, L., Feng, Y., Yin, X., & Liu, Y. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0309 · Cited by 27 · see citing works

Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response

Takeda, A., Tamano, H., Suzuki, M., Sakamoto, K., Oku, N., & Yokogoshi, H. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9732-z · Cited by 25 · see citing works

Effect of Sunlight Exposure and Different Withering Durations on Theanine Levels in Tea (Camellia sinensis)

Too, J., Kinyanjui, T. K., Wanyoko, J. K., & Wachira, F. N. (2015) · Food and Nutrition Sciences · doi:10.4236/fns.2015.611105 · Cited by 26 · see citing works

Effect of Treatment with Cyanidin-3-O- β -D-Glucoside on Rat Ischemic/Reperfusion Brain Damage

Giacomo, C. D., Acquaviva, R., Santangelo, R., Sorrenti, V., Vanella, L., Volti, G. L., D’Orazio, N., Vanella, A., & Galvano, F. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/285750 · Cited by 25 · see citing works

Reactions of green and black teas with Cu( ii )

Goodman, B. A., Severino, J. F., & Pirker, K. F. (2011) · Food & Function · doi:10.1039/c1fo10086f · Cited by 24 · see citing works

Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures

Vega‐Gálvez, A., Gómez‐Pérez, L. S., Zepeda, F., Vidal, R. L., Grünenwald, F., Mejías, N., Pastén, A., Araya, M., & Ah‐Hen, K. (2023) · Antioxidants · doi:10.3390/antiox12091789 · Cited by 23 · see citing works

Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and biochemical evidence

Sachdeva, A. K., Kuhad, A., Tiwari, V., & Chopra, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.020 · Cited by 23 · see citing works

Green Tea Extract-Patents and Diversity of Uses

Saito, S. T., Gosmann, G., Pungartnik, C., & Brendel, M. (2009) · Recent Patents on Food Nutrition & Agriculture · doi:10.2174/2212798410901030203 · Cited by 24 · see citing works

Theanine attenuates memory impairments induced by <i>klotho</i> gene depletion in mice

Nguyen, B. T., Sharma, N., Shin, E.-J., Jeong, J. H., Lee, S. H., Jang, C.-G., Nah, S.-Y., Nabeshima, T., Yoneda, Y., & Kim, H.-C. (2019) · Food &amp; Function · doi:10.1039/c8fo01577e · Cited by 22 · see citing works

Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?

Nunes, A. R., Alves, M. G., Moreira, P. I., Oliveira, P. F., & Silva, B. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141204220539 · Cited by 22 · see citing works

A Detoxified Extract ofRhus vernicifluaStokes Upregulated the Expression of BDNF and GDNF in the Rat Brain and the Human Dopaminergic Cell Line SH-SY5Y

Sapkota, K., Kim, S., Kim, M.-K., & Sung-Jun, K. I. M. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100165 · Cited by 22 · see citing works

Dietary and botanical anxiolytics

Alramadhan, E., Hanna, M. S., Hanna, M. S., Goldstein, T. G., Avila, S. M., & Weeks, B. S. (2012) · Medical Science Monitor · doi:10.12659/msm.882608 · Cited by 23 · see citing works

Synergistic effects of epigallocatechin gallate and l-theanine in nerve repair and regeneration by anti-amyloid damage, promoting metabolism, and nourishing nerve cells

Xie, X., Wan, J., Zheng, X., Pan, W., Yuan, J., Hu, B., Feng, M., Liu, Z., & Cai, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.951415 · Cited by 21 · see citing works

The application of human-derived cell lines in neurotoxicity studies of environmental pollutants

Li, M.-R., Men, S., Wang, Z., Liu, C., Zhou, G.-R., & Yan, Z. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168839 · Cited by 19 · see citing works

Impact of instantaneous controlled pressure drop on microstructural modification of green tea and its infusion quality

Wang, Y., Xu, P., Feng, L., Yang, X., & Qian, L. (2011) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0466-1 · Cited by 19 · see citing works

Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study.

Mirza, B., Ikram, H., Bilgrami, S., Haleem, D. J., & Haleem, M. A. (2013) · PubMed · Cited by 19 · see citing works

Neuroprotective effect of L-theanine on Aβ-induced neurotoxicity through anti-oxidative mechanisms in SK-N-SH and SK-N-MC cells

Jo, M.-R., Park, M.-H., Choi, D.-Y., Yuk, D.-Y., Lee, Y.-M., Lee, J.-M., Jeong, J.-H., Oh, K.-W., Lee, M.-S., Han, S.-B., et al. (2011) · Biomolecules and Therapeutics · doi:10.4062/biomolther.2011.19.3.288 · Cited by 18 · see citing works

Advantageous effect of theanine intake on cognition

Tamano, H., Fukura, K., Suzuki, M., Sakamoto, K., Yokogoshi, H., & Takeda, A. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000094 · Cited by 19 · see citing works

Therapeutic Role of <scp>l</scp>-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice

Elbaz, E. M., Ibrahim, S. M., Rashad, E., Yasin, N. A. E., Ghaiad, H. R., & Mehana, N. A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00351 · Cited by 21 · see citing works

The Involvement of L-Type Amino Acid Transporters in Theanine Transport

Yamamoto, S., Kimura, T., Tachiki, T., Anzai, N., Sakurai, T., & Ushimaru, M. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120519 · Cited by 17 · see citing works

Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion

Lu, Y.-N., Zhang, J., Wan, X., Long, M., Li, D., Lei, P., & Zhang, Z. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.027 · Cited by 17 · see citing works

The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic review

Moshfeghinia, R., Sanaei, E., Mostafavi, S., Assadian, K., Sanaei, A., & Ayano, G. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06285-y · Cited by 17 · see citing works

The function and application potential of L-theanine: From biotechnological production, biosynthesis, bioactivity to food industry

Le, J., Li, L., Wang, C., Hu, Q., Shao, K., Zhao, Y. F., & Jin, Y. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145613 · Cited by 16 · see citing works

Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway

Xin, Y., Ben, P., Wang, Q., Zhu, Y., Yin, Z., & Luo, L. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9459 · Cited by 16 · see citing works

Theanine-Modified Graphene Oxide Composite Films for Neural Stem Cells Proliferation and Differentiation

Qi, Z., Chen, X., Guo, W., Fu, C., & Pan, S. (2020) · Journal of Nanomaterials · doi:10.1155/2020/3068173 · Cited by 16 · see citing works

The Roles of Redox Enzymes in Parkinson’s Disease: Focus on Glutaredoxin

Johnson, W. M., Wilson‐Delfosse, A. L., Chen, S. G., & Mieyal, J. J. (2015) · Therapeutic Targets for Neurological Diseases · doi:10.14800/ttnd.790 · Cited by 15 · see citing works

L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice

Chen, Y., Lian, F., Lu, Q., Peng, S., Li, J., Huang, S. M., & Du, X. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00790 · Cited by 15 · see citing works

<scp>l</scp>-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures

Schallier, A., Vermoesen, K., Loyens, E., Van Liefferinge, J., Michotte, Y., Smolders, I., & Massie, A. (2013) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000033 · Cited by 14 · see citing works

Green tea: protective action against oxidative damage induced by xenobiotics

Kaushik, G., Satya, S., & Naik, S. N. (2010) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1007/s12349-010-0014-y · Cited by 14 · see citing works

The component of green tea, L-theanine protects human hepatic L02 cells from hydrogen peroxide-induced apoptosis

Li, G., Kang, J., Yao, X., Xin, Y., Wang, Q., Yin, Y., Luo, L., & Yin, Z. (2011) · European Food Research and Technology · doi:10.1007/s00217-011-1534-5 · Cited by 13 · see citing works

The health effects of black tea and flavonoids

Ruxton, C. H. S. (2009) · Nutrition & Food Science · doi:10.1108/00346650910957546 · Cited by 13 · see citing works

L-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes

Takeshima, M. (2016) · Institutional Repositories DataBase (IRDB) · doi:10.18926/54631

L-Theanine: Neuroprotective against Trichloroethylene-induced Parkinsons disease hallmarks

Justin, S. (2020) · Journal of Toxicology and Environmental Health Sciences · doi:10.5897/jtehs2020.0468 · Cited by 1 · see citing works

L-Theanine Ameliorated Rotenone-Induced Parkinsonism-like Symptoms in Rats

Chen, C.-N., Wang, M., Soung, H.-S., Chen, S., Fang, C.-H., Lin, Y.-W., & Tseng, H.-C. (2022) · Neurotoxicity Research · doi:10.1007/s12640-021-00451-w · Cited by 17 · see citing works

Neuroprotective effect of L-theanine against chronic Tramadol induced motor deficit and dopaminergic neurodegeneration in experimental rats

Singh, S. (2020) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.06.308 · Cited by 2 · see citing works

l-theanine, the unique constituent of tea, improves neuronal survivability by curtailing inflammatory responses in MPTP model of Parkinson's disease

Deb, S., & Borah, A. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105830 · Cited by 7 · see citing works