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Cited by 17Phytoestrogen effects and researchBreast Cancer Treatment StudiesEstrogen and related hormone effects

Soy consumption and histopathologic markers in breast tissue using tissue microarrays

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Maskarinec, Gertraud, Erber, Eva, Verheus, Martijn, Hernandez, Brenda Y., Killeen, Jeffrey, Cashin, Suzanne, Cline, J. Mark·2009·Nutrition and Cancer
DOI 10.1080/01635580902913047PMC PMC2903450
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Abstract

This study examined the relation of soy intake with hormonal and proliferation markers in benign and malignant breast tissue using tissue microarrays (TMAs). TMAs with up to 4 malignant and 4 benign tissue samples for 268 breast cancer cases were constructed. Soy intake in early life and in adulthood was assessed by questionnaire. The TMAs were stained for estrogen receptor (ER) alpha, ERbeta, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu), proliferating cell nuclear antigen (PCNA), and Ki-67 using standard immunohistochemical methods. Logistic regression was applied for statistical analysis. A higher percentage of women showed positive marker expression in malignant than in benign tissue. With one exception, HER2/neu, no significant associations between soy intake and pathologic markers were observed. Early life soy intake was associated with lower HER2/neu and PCNA staining of malignant tissue. In benign tissue, early life soy intake showed higher ER and PR expression, but no difference in proliferation markers. The results of this investigation provide some assurance that soy intake does not adversely affect markers of proliferation. TMAs were shown to be a useful tool for epidemiologic research.

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  • None of the RCTs assessing endometrial thickness, mammographic density or changes, nipple aspirate volume, PAP results and uterine fibroid growth, or vaginal cytology found any evidence of negative impact from soy compared to control.

    “None of the studies assessing endometrial thickness [132,136,155], mammographic density or mammographic changes [66,132,136,137,144,146], nipple aspirate volume [134], PAP results and uterine fibroid growth [132], or vaginal cytology [155] found any evidence of negative impact from soy compared to the control group.”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [66]

    The Methods describe an observational study of soy intake and breast-tissue markers, not an RCT comparing soy with a control group. Although the Results mention that participants came from an earlier mammographic-density study, this paper does not report soy’s effect on mammographic density or the other outcomes listed (Methods, Results; pages unavailable). (LLM, conf=0.76)

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Research works printed but not linked: 37

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Sorted by citations

Authors
Maskarinec, G., Erber, E., Verheus, M., Hernandez, B. Y., Killeen, J., Cashin, S., & Cline, J. M.
Affiliations
  • Cancer Center of Hawaii (US)
  • Kapiolani Medical Center for Women and Children (US)
  • Wake Forest University Health Sciences (US)
ORCID
Venue
Nutrition and Cancer
Publisher
Informa UK Limited
Published
2009-09-23
Volume
61
Issue
5
Pages
708-716
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
DOI
10.1080/01635580902913047
PMC
PMC2903450
OpenAlex
W2007323615
Cited by
17
References
0
Citations by year
2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.89
Type
journal article
Language
en
Open access
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA085265, R37CA054281, R01CA054281, R21 CA1080250, R21CA100250, R21CA108250)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
soy consumption, breast cancer, breast tissue, estrogen receptor alpha, estrogen receptor beta, progesterone receptor, HER2/neu, proliferating cell nuclear antigen, Ki-67, cell proliferation markers, benign breast tissue, tissue microarray
MeSH terms
Aged, Aging, Breast, Breast Neoplasms, Diet Surveys, Female, Humans, Immunohistochemistry, Middle Aged, Receptors, Estrogen, Receptors, Progesterone, Biomarkers, Tumor, Body Mass Index, Logistic Models, Anticarcinogenic Agents, Proliferating Cell Nuclear Antigen, Ki-67 Antigen, Soy Foods, Tissue Array Analysis, ErbB Receptors

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