The DOI matches its Crossref record.
Anticancer Activities of an Anthocyanin-Rich Extract From Black Rice Against Breast Cancer Cells In Vitro and In Vivo
Abstract
Anthocyanins widely present in human diet and have a variety of health effects. This study investigates the anticancer effects of an anthocyanin-rich extract from black rice (AEBR) on breast cancer cells in vitro and in vivo. AEBR reduced the viability of breast cancer cell lines MCF-7 (ER(+), HER2/neu(-)), MDA-MB-231 (ER(-), HER2/neu(-)), and MDA-MB-453 (ER(-), HER2/neu(+)) and induced apoptosis in MDA-MB-453 cells via the intrinsic pathway in vitro by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP), depolarizing mitochondrial membrane potential, and releasing cytochrome C. Oral administration of AEBR (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly suppressed tumor growth and angiogenesis by suppressing the expression of angiogenesis factors MMP-9, MMP-2, and uPA in tumor tissue. Altogether, this study suggests the anticancer effects of AEBR against human breast cancer cells in vitro and in vivo by inducing apoptosis and suppressing angiogenesis.
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Cited by
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1030064 · Cited by 489
“…have been demonstrated to inhibit the initiation, promotion, and progression of several cancers, such as breast cancer (Singletary et al., 2007; Hui et al., 2010; Devi et al., 2011), prostate cancer (Reddivari et al., 2007), liver cancer (Bishayee et al., 2010, 2011), colorectal and intestinal…”
BackgroundEffects of anthocyanins on the prevention and treatment of cancer
Lin, B., Gong, C., Song, H., & Cui, Y. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13627 · Cited by 435
Strawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312
Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies
Hui, C., Qi, X., Qianyong, Z., Xiaoli, P., Jundong, Z., & Mantian, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054318 · Cited by 245
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Metadata
- Authors
- Hui, C., Bin, Y., Xiaoping, Y., Long, Y., Chunye, C., Mantian, M., & Wenhua, L.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2010-11-05
- Volume
- 62
- Issue
- 8
- Pages
- 1128-1136
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W1977028616
- Cited by
- 213
- References
- 0
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hui, C., Bin, Y., Xiaoping, Y., Long, Y., Chunye, C., Mantian, M., & Wenhua, L. (2010). Anticancer Activities of an Anthocyanin-Rich Extract From Black Rice Against Breast Cancer Cells In Vitro and In Vivo. Nutrition and Cancer. https://doi.org/10.1080/01635581.2010.494821
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