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Anthocyanins: Natural Colorants with Health-Promoting Properties

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Prospective study of alcohol consumption and risk of coronary disease in men.

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Concentrations of Anthocyanins in Common Foods in the United States and Estimation of Normal Consumption

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Anthocyanins and their role in cancer prevention

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Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women

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Anthocyanins in Fruits, Vegetables, and Grains

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The bioavailability and absorption of anthocyanins: Towards a better understanding

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Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies

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Anthocyanins: from plant to health

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High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

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Anthocyanins in Cardiovascular Disease

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Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice

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Anthocyanin‐ and hydrolyzable tannin‐rich pomegranate fruit extract modulates MAPK and NF‐κB pathways and inhibits skin tumorigenesis in CD‐1 mice

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Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.

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Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system

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Bioavailability of anthocyanins and derivatives

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Dietary Polyphenols and Type 2 Diabetes: Current Insights and Future Perspectives

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Effects of Commercial Anthocyanin-Rich Extracts on Colonic Cancer and Nontumorigenic Colonic Cell Growth

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Recent Advances in Anthocyanin Analysis and Characterization

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Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b

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Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial

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Structure−Function Relationships of Anthocyanins from Various Anthocyanin-Rich Extracts on the Inhibition of Colon Cancer Cell Growth

Jing, P., Bomser, J. A., Schwartz, S. J., He, J., Magnuson, B. A., & Giusti, M. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8005917 · Cited by 268 · see citing works

Anthocyanin-Rich Extracts Inhibit Multiple Biomarkers of Colon Cancer in Rats

Lala, G., Malik, M., Zhao, C., He, J., Kwon, Y., Giusti, M. M., & Magnuson, B. A. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_10 · Cited by 254 · see citing works

An Anthocyanin-Rich Extract from Black Rice Enhances Atherosclerotic Plaque Stabilization in Apolipoprotein E–Deficient Mice

Xia, X., Ling, W., Ma, J., Xia, M., Hou, M., Wang, Q., Zhu, H., & Tang, Z. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2220 · Cited by 232 · see citing works

Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved

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Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

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Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals

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Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

Shih, P., Chan, Y., Liao, J., Wang, M.-F., & Yen, G. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.008 · Cited by 220 · see citing works

Strawberry anthocyanin and its association with postprandial inflammation and insulin

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Anticancer Activities of an Anthocyanin-Rich Extract From Black Rice Against Breast Cancer Cells In Vitro and In Vivo

Hui, C., Yu, B., Yu, X., Yi, L., Chunye, C., Mi, M., & Ling, W. (2010) · Nutrition and Cancer · doi:10.1080/01635581.2010.494821 · Cited by 213 · see citing works

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes

Tsuda, T., Ueno, Y., Aoki, H., Koda, T., Horio, F., Takahashi, N., Kawada, T., & Osawa, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.031 · Cited by 212 · see citing works

Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans

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Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine

Hagiwara, A., Miyashita, K., Nakanishi, T., Sano, M., Tamano, S., Kadota, T., Koda, T., Nakamura, M., Imaida, K., Ito, N., et al. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00510-9 · Cited by 207 · see citing works

Anthocyanin-rich Açai (Euterpe oleracea Mart.) Fruit Pulp Fractions Attenuate Inflammatory Stress Signaling in Mouse Brain BV-2 Microglial Cells

Poulose, S. M., Fisher, D. R., Larson, J., Bielinski, D. F., Rimando, A. M., Carey, A. N., Schauss, A. G., & Shukitt‐Hale, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203989k · Cited by 204 · see citing works

Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways

Reddivari, L., Vanamala, J., Chintharlapalli, S. R., Safe, S. H., & Miller, J. C. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm117 · Cited by 197 · see citing works

Antioxidant and Antiproliferative Activities of Anthocyanin/Ellagitannin-Enriched Extracts FromSyzygium cuminiL. (Jamun, the Indian Blackberry)

Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R. J., Singh, I. P., & Gupta, R. C. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.657766 · Cited by 188 · see citing works

Anthocyanin-Rich Extract From Aronia meloncarpa E. Induces a Cell Cycle Block in Colon Cancer but Not Normal Colonic Cells

Malik, M., Zhao, C., Schoene, N. W., Guisti, M. M., Moyer, M. P., & Magnuson, B. A. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4602_12 · Cited by 184 · see citing works

Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention

Lim, S., Xu, J., Kim, J., Chen, T., Su, X., Standard, J., Carey, E. E., Griffin, J., Herndon, B., Katz, B. B., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300040 · Cited by 183 · see citing works

Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat

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Effect of Anthocyanin-Rich Extract from Black Rice (Oryza sativa L. indica) on Hyperlipidemia and Insulin Resistance in Fructose-Fed Rats

Guo, H., Ling, W., WANG, Q., Liu, C., HU, Y., Xia, M., Feng, X., & Xia, X. (2006) · Plant Foods for Human Nutrition · doi:10.1007/s11130-006-0031-7 · Cited by 175 · see citing works

Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells

Bunea, A., Rugină, D. O., Diaconeasa, Z. M., Pop, R. M., Pintea, A., Socaciu, C., Tăbăran, F., Grootaert, C., Struijs, K., & VanCamp, J. (2013) · Phytochemistry · doi:10.1016/j.phytochem.2013.06.018 · Cited by 174 · see citing works

A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: Extraction methods, stability, anticancer properties and mechanisms

Dai, J., Gupte, A., Gates, L., & Mumper, R. J. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.01.016 · Cited by 167 · see citing works

Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis

Li, L., Wang, L., Wu, Z., Yao, L., Wu, Y., Huang, L., Liu, K., Zhou, X., & Gou, D. (2014) · Scientific Reports · doi:10.1038/srep06234 · Cited by 156 · see citing works

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer’s disease

Vepsäläinen, S., Koivisto, H., Pekkarinen, E., Mäkinen, P., Dobson, G., McDougall, G. J., Stewart, D., Haapasalo, A., Karjalainen, R. O., Tanila, H., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.006 · Cited by 150 · see citing works

Regulation of Glucose Transporter Expression in Human Intestinal Caco-2 Cells following Exposure to an Anthocyanin-Rich Berry Extract

Alzaïd, F., Cheung, H.-M., Preedy, V. R., & Sharp, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078932 · Cited by 149 · see citing works

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats

Bishayee, A., Mbimba, T., Thoppil, R. J., Háznagy‐Radnai, E., Sipos, P., Darvesh, A. S., Folkesson, H. G., & Hohmann, J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.09.001 · Cited by 134 · see citing works

Cyanidin 3-O-.BETA.-D-glucoside Suppresses Nitric Oxide Production during a Zymosan Treatment in Rats.

Tsuda, T., Horio, F., & Osawa, T. (2002) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.48.305 · Cited by 132 · see citing works

Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species

You, J., Kim, J., Lim, J., & Lee, E. (2010) · Theriogenology · doi:10.1016/j.theriogenology.2010.04.002 · Cited by 127 · see citing works

Chemoprevention of Esophageal Cancer with Black Raspberries, Their Component Anthocyanins, and a Major Anthocyanin Metabolite, Protocatechuic Acid

Peiffer, D. S., Zimmerman, N. P., Wang, L.-S., Ransom, B. W. S., Carmella, S. G., Kuo, C.-T., Siddiqui, J. H., Chen, J.-H., Oshima, K., Huang, Y., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0003 · Cited by 126 · see citing works

Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism

Miyake, S., Takahashi, N. K., Sasaki, M., Kobayashi, S., Tsubota, K., & Ozawa, Y. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.132 · Cited by 124 · see citing works

Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma

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Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction

Liu, Y., Li, D., Zhang, Y., Sun, R., & Xia, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00699.2013 · Cited by 123 · see citing works

Effect of Anthocyanin Fractions from Selected Cultivars of Georgia-Grown Blueberries on Apoptosis and Phase II Enzymes

Srivastava, A., Akoh, C. C., Fischer, J. G., & Krewer, G. W. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062915o · Cited by 122 · see citing works

Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia

Min, J., Yu, S.-W., Baek, S., Nair, K. M., Bae, O., Bhatt, A., Kassab, M. Y., Nair, M. G., & Majid, A. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.048 · Cited by 116 · see citing works

The anthocyanin metabolites gallic acid, 3-O -methylgallic acid, and 2,4,6-trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro-oncogenic signals

Forester, S. C., Choy, Y. Y., Waterhouse, A. L., & Oteiza, P. I. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21974 · Cited by 116 · see citing works

Mulberry anthocyanin extracts inhibit LDL oxidation and macrophage-derived foam cell formation induced by oxidative LDL

Liu, L. ‐., Lee, H. ‐., Shih, Y. ‐., Chyau, C. ‐., & Wang, C. ‐. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00801.x · Cited by 115 · see citing works

Potential Chemopreventive Properties of Anthocyanin-Rich Aqueous Extracts from In Vitro Produced Tissue of Sweetpotato (Ipomoea batatas L.)

Konczak, I., Yoshimoto, M., Hou, D., Terahara, N., & Yamakawa, O. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030066o · Cited by 115 · see citing works

Anthocyanin-Rich Grape Extract Blocks Breast Cell DNA Damage

Singletary, K. W., Jung, K.-J., & Giusti, M. M. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.258 · Cited by 113 · see citing works

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

Rugină, D. O., Diaconeasa, Z. M., LEOPOLD, L. F., Pintea, A., Bunea, A., & Socaciu, C. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0246 · Cited by 108 · see citing works

Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice

Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenković, D. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.04.011 · Cited by 103 · see citing works

Antitumor Effect of Anthocyanin Fractions Extracted from Red Soybeans and Red Beans in vitro and in vivo

Koide, T., Hashimoto, Y., Kamei, H., Kojima, T., Hasegawa, M., & Terabe, K. (1997) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.1997.12.277 · Cited by 101 · see citing works

Estimated Daily Flavonoid and Stilbene Intake from Fruits, Vegetables, and Nuts and Associations with Lipid Profiles in Chinese Adults

Li, G., Zhu, Y., Zhang, Y., Jing, L., Chen, Y., & Ling, W. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.01.018 · Cited by 96 · see citing works

Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution

Xia, M., Ling, W., Zhu, H., Wang, Q., Ma, J., Hou, M., Tang, Z., Li, L., & Ye, Q. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000254672.04573.2d · Cited by 96 · see citing works

Dietary Anthocyanin-Rich Tart Cherry Extract Inhibits Intestinal Tumorigenesis in APCMin Mice Fed Suboptimal Levels of Sulindac

Bobe, G., Wang, B., Seeram, N. P., Nair, M. G., & Bourquin, L. D. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0612169 · Cited by 90 · see citing works

Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins

de Pascual‐Teresa, S. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.04.012 · Cited by 88 · see citing works

An anthocyanin-rich extract from Kamchatka honeysuckle increases enzymatic activity within the gut and ameliorates abnormal lipid and glucose metabolism in rats

Jurgoński, A., Juśkiewicz, J., & Zduńczyk, Z. (2013) · Nutrition · doi:10.1016/j.nut.2012.11.006 · Cited by 88 · see citing works

Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats

Gräf, D., Seifert, S., Jaudszus, A., Bub, A., & Watzl, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066690 · Cited by 88 · see citing works

Cyanidin-3-O-β-glucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase

Guo, H., Guo, J.-B., Jiang, X., Zhen, L., & Ling, W. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.015 · Cited by 87 · see citing works

Immunomodulatory Effect of a Wild Blueberry Anthocyanin-Rich Extract in Human Caco-2 Intestinal Cells

Taverniti, V., Fracassetti, D., Bo’, C. D., Lanti, C., Minuzzo, M., Klimis‐Zacas, D. J., Riso, P., & Guglielmetti, S. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf502180j · Cited by 87 · see citing works

Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice

Wu, T., Yu, Z., Tang, Q., Song, H., Gao, Z., Chen, W., & Zheng, X. (2013) · Food & Function · doi:10.1039/c3fo60251f · Cited by 86 · see citing works

Antitumor Effect of Hydrolyzed Anthocyanin from Grape Rinds and Red Rice

Koide, T., Kamei, H., Hashimoto, Y., Kojima, T., & Hasegawa, M. (1996) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.1996.11.273 · Cited by 80 · see citing works

Anthocyanin-Rich Black Currant Extract Suppresses the Growth of Human Hepatocellular Carcinoma Cells

Bishayee, A., Háznagy‐Radnai, E., Mbimba, T., Sipos, P., Morazzoni, P., Darvesh, A. S., Bhatia, D., & Hohmann, J. (2010) · Natural Product Communications · doi:10.1177/1934578x1000501020 · Cited by 76 · see citing works

Effect of Purple Sweet Potato Anthocyanins on β-Amyloid-Mediated PC-12 Cells Death by Inhibition of Oxidative Stress

Ye, J., Meng, X., Yan, C., & Wang, C. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0063-0 · Cited by 74 · see citing works

Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)

Devi, P. S., Kumar, M. S., & Das, S. M. (2011) · International Journal of Breast Cancer · doi:10.4061/2011/891481 · Cited by 68 · see citing works

Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach

Paixão, J., Dinis, T. C. P., & Almeida, L. M. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0632-y · Cited by 67 · see citing works

In vitro effects of anthocyanin extracts from Justicia secunda Vahl on the solubility of haemoglobin S and membrane stability of sickle erythrocytes.

Mpiana, P. T., Ngbolua, K.-T.-N., Bokota, M. T., Kasonga, T. K., Atibu, E. K., Tshibangu, D. S. T., & Mudogo, V. (2010) · PubMed Central · doi:10.2450/2009.0120-09 · Cited by 66 · see citing works

Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation

Xia, M., Ling, W., Zhu, H., Ma, J., Wang, Q., Hou, M., Tang, Z., Guo, H., Liu, C., & Ye, Q. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.005 · Cited by 66 · see citing works

Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice

Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A., & Milenković, D. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0171-0 · Cited by 65 · see citing works

Anthocyanin Extracted from Black Soybean Reduces Prostate Weight and Promotes Apoptosis in the Prostatic Hyperplasia-Induced Rat Model

Jang, H. J., Ha, U., Kim, S., Yoon, B.-I., Han, D.-S., Yuk, S. M., & Kim, S.-W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102688g · Cited by 63 · see citing works

Inhibition of Carrageenan-Induced Acute Inflammation in Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside

Hassimotto, N. M. A., Moreira, V., Nascimento, N. G., Souto, P. C. M. D. C., Teixeira, C., & Lajolo, F. M. (2013) · BioMed Research International · doi:10.1155/2013/146716 · Cited by 62 · see citing works

Anthocyanin extracted from Hibiscus attenuate oxidized LDL-mediated foam cell formation involving regulation of CD36 gene

Kao, E., Tseng, T., Lee, H., Chan, K., & Wang, C. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.01.009 · Cited by 58 · see citing works

Chemical Analysis and Screening as Anticancer Agent of Anthocyanin-Rich Extract from Uva Caimarona (Pourouma cecropiifolia Mart.) Fruit

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Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK–mTOR Signaling Pathway in Aged Female Rats

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Special issue on anthocyanins

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