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Cited by 343Reproductive Physiology in LivestockRuminant Nutrition and Digestive PhysiologyAnimal health and immunology

The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.

Non-esterified fatty acids (NEFA) in dairy cattle. A review

Adewuyi, A.A., Gruys, E., van Eerdenburg, F.J.C.M.·2005·Veterinary Quarterly
DOI 10.1080/01652176.2005.9695192
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Abstract

The objective of this report is to review the literature on elevated blood concentrations of nonesterified fatty acids (NEFA) before and after parturition in high-yielding dairy cows. It highlights the factors that influence serum NEFA production and their circulation before and after parturition, such as adaptation for nutrient partitioning for fetal needs, onset of lactogenesis, stress of calving and numerous changes in physiological, metabolic, and endocrine status to accommodate parturition and lactogenesis. The role of NEFA in the liver and peripheral tissues and its toxic effects when in excess are discussed. The cow's adaptive physiologic mechanisms to prevent or decrease excessive values of serum NEFA and preventive and therapeutic interventions to enhance these mechanisms are categorized as natural and artificial antidotes respectively. Feeding systems during the dry period and daily exercise or walking activity which may burn excessive NEFA through beta-oxidation in the muscles are considered as more useful antidotes to managing the NEFA metabolism. This will minimize accumulation of lipids in the liver during early lactation and alleviate the negative effects of plasma NEFA leading to more optimal metabolic health and productivity of dairy cows.

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Crossref · 10.1080/01652176.2005.9695192

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Citations

Cites

Research works printed but not linked: 23

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  2. Barker BO, 1975, Journal of Dairy Science, 58, 749
  3. Bennink MR, 1972, Journal of Dairy Science, 55, 712
  4. Block, E and Sanchez, W. 2000. Special nutritional needs of the transition cow. Mid‐south ruminant nutrition conference. 2000, Dallas, Texas. pp.1–15.
  5. Bryers, DI. 1999. Controlling metabolic diseases. Tri‐state Dairy Nutrition Conference Grand. April20–211999, Wayne Center Fort Wayne, Indiana.
  6. Douglas GN, 1998, Journal of Dairy Science, 81, 295
  7. Drackley JK, 2000, Illinois Dairy Days
  8. Gustafson GM, 1994, Regular exercise to tied dairy cows. Effects on productivity, health and locomotion and with attention paid to the influence of light
  9. Herdt, TH. 1997. Gastrointestinal physiology and metabolism. Textbook of Veterinary Physiology, , 2 nd edition, Edited by: Cunningham, J.G. 263–380. WB Sanders Company. 1997
  10. Herdt TH, 1997, Michigan Dairy Review, 2
  11. Knapp JR, 1990, Journal of Animal Science, 68, 522
  12. 2001, Nutrient requirements of Dairy Cattle.
  13. Nelson DL, 2005, Lehninger Principles of Biochemistry,, 600
  14. Oldick, BS. 1999. Effect of level and source of energy during the periparturient period on reproductive performance. Tri‐state Dairy Nutrition Conference. April20–211999, Grand Wayne Center Fort Wayne, Indiana.
  15. Overton TR, 2001, Advances in Dairy Technology, 13, 17
  16. Roach, JO and Benyon, S. 2003. Lipid metabolism and transport. Metabolism and Nutrition, , 2 nd edition, 55–80. Mosby: Elsevier.
  17. Serjrsen K, 1981, Nutritional Physiology and Feeding of the Cow around Parturition., 20, 325
  18. Shearer JK, 1992, Large Dairy Herds Management, 358
  19. Spain, JN and Scheer, WA. 2001. The 100‐day contract with the dairy cows: Thirty days prepartum to seventy days postpartum. Tri‐state Dairy Nutrition Conference. April17–182001, Grand Wayne Center Fort Wayne, Indiana.
  20. Underwood, JP. 1998. “Effects of feeding palatability enhancer in transition cow diet on performance of Holstein dairy cows”. University of Missouri‐Columbia. Master of Science Thesis,
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  22. Van den Top, AM. 1995. “Diet and lipid metabolism in ruminants with particular reference to fatty liver development”. The Netherlands: Utrecht University. Thesis,
  23. Vernon RG, 1998, Research Reviews, Hannah Research Institute Yearbook, 64

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Metadata

Authors
Adewuyi, A. A., Gruys, E., & van Eerdenburg, F. J. C. M.
Affiliations
Utrecht University (NL)
Venue
Veterinary Quarterly
Publisher
Informa UK Limited
Published
2005-09
Volume
27
Issue
3
Pages
117-126
ISSN
  • 0165-2176 (ISSN-L)
  • 1875-5941
DOI
10.1080/01652176.2005.9695192
OpenAlex
W2049628589
Cited by
343
References
80
Citations by year
2026: 19 · 2025: 30 · 2024: 22 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 33 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 9 · 2015: 16 · 2014: 20 · 2013: 8 · 2012: 6
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Locations
  • Veterinary Quarterly (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
Keywords
free fatty acids, dairy cattle, childbirth, lactogenesis, hepatic lipid accumulation, fatty acid beta-oxidation, dry period feeding, physical activity, endocrine changes, antidotes
MeSH terms
Adaptation, Physiological, Animals, Cattle, Fatty Acids, Nonesterified, Female, Lactation, Nutritional Requirements, Pregnancy, Parturition

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