Cited by 343Reproductive Physiology in LivestockRuminant Nutrition and Digestive PhysiologyAnimal health and immunology

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Non-esterified fatty acids (NEFA) in dairy cattle. A review

Adewuyi, A.A., Gruys, E., van Eerdenburg, F.J.C.M.·2005·Veterinary Quarterly

DOI 10.1080/01652176.2005.9695192

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Abstract

The objective of this report is to review the literature on elevated blood concentrations of nonesterified fatty acids (NEFA) before and after parturition in high-yielding dairy cows. It highlights the factors that influence serum NEFA production and their circulation before and after parturition, such as adaptation for nutrient partitioning for fetal needs, onset of lactogenesis, stress of calving and numerous changes in physiological, metabolic, and endocrine status to accommodate parturition and lactogenesis. The role of NEFA in the liver and peripheral tissues and its toxic effects when in excess are discussed. The cow's adaptive physiologic mechanisms to prevent or decrease excessive values of serum NEFA and preventive and therapeutic interventions to enhance these mechanisms are categorized as natural and artificial antidotes respectively. Feeding systems during the dry period and daily exercise or walking activity which may burn excessive NEFA through beta-oxidation in the muscles are considered as more useful antidotes to managing the NEFA metabolism. This will minimize accumulation of lipids in the liver during early lactation and alleviate the negative effects of plasma NEFA leading to more optimal metabolic health and productivity of dairy cows.

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Authors: Adewuyi, A. A., Gruys, E., & van Eerdenburg, F. J. C. M.
Affiliations: Utrecht University (NL)
Venue: Veterinary Quarterly
Publisher: Informa UK Limited
Published: 2005-09
Volume: 27
Issue: 3
Pages: 117-126
ISSN: 0165-2176 (ISSN-L)
1875-5941
DOI: 10.1080/01652176.2005.9695192
OpenAlex: W2049628589
Cited by: 343
References: 80
Citations by year: 2026: 19 · 2025: 30 · 2024: 22 · 2023: 34 · 2022: 26 · 2021: 32 · 2020: 33 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 9 · 2015: 16 · 2014: 20 · 2013: 8 · 2012: 6
FWCI: 1.18
Type: journal article
Language: en
Open access: closed
Locations: Veterinary Quarterly (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
Keywords: free fatty acids, dairy cattle, childbirth, lactogenesis, hepatic lipid accumulation, fatty acid beta-oxidation, dry period feeding, physical activity, endocrine changes, antidotes
MeSH terms: Adaptation, Physiological, Animals, Cattle, Fatty Acids, Nonesterified, Female, Lactation, Nutritional Requirements, Pregnancy, Parturition

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Non-esterified fatty acids (NEFA) in dairy cattle. A review

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