Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program
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The NTP has a long history of using Fischer rats and has compiled a large database of incidences of lesions seen in control animals. Such a database is lacking for Harlan Sprague-Dawley (SD) rats. The intention of this paper is to report spontaneous lesions observed in female vehicle control Harlan SD rats, and to compare the incidence in 2 strains of rats (Fischer and Harlan SD) used in NTP studies. Female Harlan SD rats served as the test animals for a special series of 2-year studies. Male rats were not used in these studies. Complete histopathology was performed on all animals, and the pathology results underwent comprehensive NTP pathology peer review. The most commonly observed neoplasms in these female control Harlan SD rats were mammary gland fibroadenoma (71%), tumors of the pars distalis of the pituitary (41%) and thyroid gland C-cell tumors (30%). Female Fischer rats had incidences of 44% for mammary gland fibroadenomas, 34% for tumors of the pars distalis, and 16% for thyroid gland C-cell tumors. Fischer rats had a 15% incidence of clitoral gland tumors, while the Harlan SD rats had an incidence of < 1%. In contrast to Fischer F344 rats, the Harlan SD rats had a high incidence of squamous metaplasia of the uterus (44.2%). Squamous metaplasia is not a lesion commonly observed in NTP control Fischer rats. The Harlan SD rats had a very low incidence of mononuclear cell leukemia (0.5%), compared with an incidence of 24% in female Fischer rats.
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All treatments in both sexes enhanced large tumor incidence by 2-3-fold in comparison to controls, and also the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain, and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats.
“All treatments in both sexes enhanced large tumor incidence by 2-3-fold in com- parison to our controls but also for the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain (Brix et al., 2005), and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats (Chandra et al., 1992).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Brix et al., 2005
All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats.
“All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to our controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain [56] and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats [57].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [56]
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- Authors
- Brix, A. E., Nyska, A., Haseman, J. K., Sells, D. M., Jokinen, M. P., & Walker, N. J.
- Affiliations
- Experimental Pathology Laboratories (US)
- National Institute of Environmental Health Sciences (US)
- Battelle (US)
- Pathology Associates—A Charles River Company, Durham, North Carolina 27713, USA
- Corresponding author
- Brix, Amy E.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2005-06
- Volume
- 33
- Issue
- 4
- Pages
- 477-483
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2068971806
- Cited by
- 50
- References
- 16
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 9
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicologic Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
- Keywords
- Fischer rats, spontaneous neoplasms, mononuclear cell leukemia, strain comparison, National Toxicology Program
- MeSH terms
- Animals, Female, Neoplasms, Rodent Diseases, United States, United States Dept. of Health and Human Services, Carcinogenicity Tests, Rats, Sprague-Dawley, Toxicity Tests, Chronic, Rats
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