Allergenicity and allergens of amphipods found in nori (dried laver)
Abstract
Gammaridean and caprellid amphipods, crustaceans of the order Amphipoda, inhabit laver culture platforms and, hence, are occasionally found in nori (dried laver) sheets. Amphipods mixed in nori may cause allergic reactions in sensitized patients, as is the case with other crustaceans, such as shrimp and crab, members of the order Decapoda. In this study, dried samples of amphipods (unidentified) found in nori and fresh samples of gammaridean amphipod (Gammarus sp., not accurately identified) and caprellid amphipod (Caprella equilibra) were examined for allergenicity and allergens using two species of decapods (black tiger prawn and spiny lobster) as references. When analyzed by ELISA, sera from crustacean-allergic patients reacted to extracts from amphipod samples, although less potently than to the extracts from decapods. In IgE-immunoblotting, a 37-kDa protein was found to be the major allergen in amphipods. Based on the molecular mass and the cross-reactivity with decapod tropomyosin evidenced by inhibition ELISA and inhibition immunoblotting, the 37-kDa protein was identified as amphipod tropomyosin.
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Studies evaluating allergenicity of nori sheets identified amphipod-derived tropomyosin as the principal allergen; however, detected levels were minimal, suggesting hypersensitivity reactions following ingestion would be uncommon.
“For instance, studies evaluating the allergenicity of nori sheets identified amphipod-derived tropomyosin as the principal allergen; however, detected levels were minimal, suggesting that hypersensitivity reactions following ingestion would be uncommon [252].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [252]
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“For instance, studies evaluating the allergenicity of nori sheets identified amphipod-derived tropomyosin as the principal allergen; however, detected levels were minimal, suggesting that hypersensitivity reactions following ingestion would be uncommon [252].”
- Authors
- Motoyama, K., Hamada, Y., Nagashima, Y., & Shiomi, K.
- Affiliations
- Tokyo University of Marine Science and Technology (JP)
- Nagasaki University (JP)
- Corresponding author
- Shiomi, Kazuo
- Venue
- Food Additives and Contaminants
- Publisher
- Informa UK Limited
- Published
- 2007-09
- Volume
- 24
- Issue
- 9
- Pages
- 917-922
- ISSN
- 0265-203X (ISSN-L)
- OpenAlex
- W1989255539
- Cited by
- 22
- References
- 17
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2019: 1 · 2017: 1 · 2014: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Additives & Contaminants (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- Amphipoda, nori, dried laver, food allergens, crustacean allergy, Gammarus, Caprella equilibra, tropomyosin, allergenicity, cross-reactivity, black tiger prawn, spiny lobster, IgE immunoblotting, inhibition ELISA
- MeSH terms
- Allergens, Animals, Cross Reactions, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Food Contamination, Food Hypersensitivity, Hot Temperature, Humans, Immunoglobulin E, Tropomyosin, Immunoblotting, Amphipoda, Palinuridae, Penaeidae, Porphyra
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