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Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense?
Open accessAbstract
More than 20 years ago, it was hypothesized that intracellular hyperthermia is superior to extracellular hyperthermia. It was further hypothesized that even a single biological cell containing magnetic nanoparticles can be treated for hyperthermia by an AC magnetic field, independent of its surrounding cells. Since experimental investigation of the thermal effects of intracellular hyperthermia is not feasible, these hypotheses have been studied theoretically. The current report shows that nano-scale heating effects are negligible. This study further shows that intracellular heat generation is sufficient to create the necessary conditions for hyperthermia only in a large group of cells loaded with nanoparticles, having an overall diameter of at least 1mm. It is argued in this report that there is no reason to believe that intracellular hyperthermia is superior to extracellular hyperthermia in the thermal sense.
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Cited by
Progress in applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Thanh, N. T. K., Jones, S. K., & Dobson, J. (2009) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/42/22/224001 · Cited by 1,455
Dutz, S., & Hergt, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.822993 · Cited by 522
Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice
Stanley, S. A., Gagner, J. E., Damanpour, S., Yoshida, M., Dordick, J. S., & Friedman, J. M. (2012) · Science · doi:10.1126/science.1216753 · Cited by 490
Kim, D.-H., Nikles, D. E., Johnson, D. T., & Brazel, C. S. (2008) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2008.05.023 · Cited by 339
Optimizing Magnetic Nanoparticle Based Thermal Therapies Within the Physical Limits of Heating
Etheridge, M. L., & Bischof, J. C. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0633-1 · Cited by 64
Metadata
- Authors
- Rabin, Y.
- Venue
- International Journal of Hyperthermia
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 18
- Issue
- 3
- Pages
- 194-202
- ISSN
- 0265-6736 (ISSN-L)
- 1464-5157
- OpenAlex
- W2002819872
- Cited by
- 212
- References
- 0
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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