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Cited by 371

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Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound

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Xu, Zhen, Hall, Timothy L., Vlaisavljevich, Eli, Lee, Fred T.·2021·International Journal of Hyperthermia
DOI 10.1080/02656736.2021.1905189
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Abstract

Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1-2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies.

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Metadata

Authors
Xu, Z., Hall, T. L., Vlaisavljevich, E., & Lee, F. T.
Venue
International Journal of Hyperthermia
Publisher
Informa UK Limited
Published
2021-01-01
Volume
38
Issue
1
Pages
561-575
ISSN
  • 0265-6736 (ISSN-L)
  • 1464-5157
DOI
10.1080/02656736.2021.1905189
OpenAlex
W3148375137
Cited by
371
References
49
FWCI
13.72
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • US National Institutes of Health (R01 EB008998, R01 CA 211217, R01 NS108042, R01 DK 091267, R01 HL141967, R01 EB 028309)
  • American Cancer Society (RSG-13-101-01-CCE)
  • Hartwell Foundation
  • Focus Ultrasound Foundation

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CoChat. (2026). Citation check: Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound. https://app.cochat.ai/papers/10.1080/02656736.2021.1905189
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Xu, Z., Hall, T. L., Vlaisavljevich, E., & Lee, F. T. (2021). Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound. International Journal of Hyperthermia. https://doi.org/10.1080/02656736.2021.1905189

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