Extended radical mastectomy versus simple mastectomy followed by radiotherapy in primary breast cancer. A fifty-year follow-up to the Copenhagen Breast Cancer randomised study
Open accessAbstract
From November 1951 to December 1957, 666 consecutive patients with untreated primary breast cancer admitted to the Radium Center in Copenhagen were randomised before their operability was evaluated into two groups, simple mastectomy with postoperative radiotherapy or extended radical mastectomy. Following physical examination 241 of the patients were excluded, primarily due to tumours deemed inoperable due to clinical criteria (n =107) and due to poor general condition (n =69). Twenty-five years results of disease-free free survival and fifty years results of survival are presented, showing no difference between the two groups. Patients with clinical stage I did significantly better than patients with stage II-III tumours. Patients with grade I tumours had a better survival than patients with grade II-III. The breast cancer associated mortality was lower in premenopausal patients compared to postmenopausal patients. An excess mortality due to breast cancer was evident up to 20-25 years following the primary diagnosis.
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Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
- Authors
- Johansen, H., Kaae, S., Johansen, H., Kaae, S., Jensen, M.-B., & Mouridsen, H. T.
- Affiliations
- Danish Breast Cancer Cooperative Group (DK)
- Rigshospitalet (DK)
- Corresponding author
- Mouridsen, Henning T.
- ORCID
- Jensen, Maj-Britt
- Venue
- Acta Oncologica
- Published
- 2008-01
- Volume
- 47
- Issue
- 4
- Pages
- 633-638
- ISSN
- 0284-186X (ISSN-L)
- 1651-226X
- OpenAlex
- W2169429521
- Cited by
- 17
- References
- 14
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2017: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Oncologica (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- primary breast cancer, extended radical mastectomy, total mastectomy, postoperative radiotherapy, long-term survival, disease-free survival, tumor stage, tumor grade, menopausal status, breast cancer mortality
- MeSH terms
- Adult, Aged, Breast Neoplasms, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Middle Aged, Mastectomy, Extended Radical, Mastectomy, Simple, Survival Rate, Premenopause, Postmenopause
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