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Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins
Abstract
Bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP), enamelin (ENAM), matrix extracellular phosphoglycoprotein (MEPE), and osteopontin (OPN) are glycophosphoproteins expressed in bones and/or teeth. Direct comparison of their amino acid sequences do not suggest that they belong to a single genetic family, but a detailed analysis of their chromosomal location and gene structure does. Analysis of human brain mRNA by RT-PCR has led to the discovery of two additional exons thereby making it more convincing that MEPE is a member of the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family. We propose that the members of this SIBLING family are extended, flexible proteins in solution that can facilitate the formation of a number of different complexes. For example, OPN can bridge complement Factor H to either an RGD-dependent integrin or to CD44 forming a membrane-bound complex that actively suppresses the alternate complement pathway. Two possible mechanisms for inhibiting the lytic pathway of alternate complement are presented.
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Cited by
Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199
Phosphorylated Proteins and Control over Apatite Nucleation, Crystal Growth, and Inhibition
George, A., & Veis, A. (2008) · Chemical Reviews · doi:10.1021/cr0782729 · Cited by 745
Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering
Liu, Y., Luo, D., & Wang, T. (2016) · Small · doi:10.1002/smll.201600626 · Cited by 482
The role of matrix metalloproteinases (MMPs) in human caries
Chaussain-Miller, C., Fioretti, F., Goldberg, M., & Menashi, S. (2006) · Journal of Dental Research · doi:10.1177/154405910608500104 · Cited by 481
Endocrine functions of bone in mineral metabolism regulation
Quarles, L. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36479 · Cited by 459
Metadata
- Authors
- Fisher, L. W., & Fedarko, N. S.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 44
- Issue
- 1
- Pages
- 33-40
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2112698502
- Cited by
- 482
- References
- 0
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fisher, L. W., & Fedarko, N. S. (2003). Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins. Connective Tissue Research. https://doi.org/10.1080/03008200390152061
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