Endocrine functions of bone in mineral metabolism regulation

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis

Block, G. A., Klassen, P., Lazarus, J. M., Ofsthun, N. J., Lowrie, E. G., & Chertow, G. M. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000133041.27682.a2 · Cited by 2,684 · see citing works

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729 · see citing works

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503 · see citing works

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391 · see citing works

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419081 · Cited by 1,368 · see citing works

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K., Baum, M., Schiavi, S., Hu, M.-C., Moe, O., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,356 · see citing works

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

Feng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · see citing works

Evolution of the Fgf and Fgfr gene families.

Itoh, N., & Ornitz, D. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.08.007 · Cited by 1,123 · see citing works

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

Francis, F., Hennig, S., Korn, B., Reinhardt, R., de Jong, P., Poustka, A. J., Lehrach, H. R., Rowe, P. S., Goulding, J. N., Summerfield, T. C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-130 · Cited by 1,095 · see citing works

The parathyroid is a target organ for FGF23 in rats

Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951 · see citing works

Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease

Gutiérrez, O. M., Isakova, T., Rhee, E. P., Shah, A., Holmes, J., Collerone, G., Diaeresis]ppner, H. J., & Wolf, M. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010052 · Cited by 920 · see citing works

Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia

Jonsson, K. B., Zahradnik, R. J., Larsson, T. E., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 904 · see citing works

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

Riminucci, M., Collins, M. T., Fedarko, N. S., Cherman, N., Corsi, A., White, K. E., Waguespack, S. G., Gupta, A., Hannon, T. S., Econs, M. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18399 · Cited by 656 · see citing works

Fibroblast Growth Factor 23 Is a Counter-Regulatory Phosphaturic Hormone for Vitamin D

Liu, S., Tang, W., Zhou, J., Stubbs, J. R., Luo, Q., Pi, M., & Quarles, L. D. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005111185 · Cited by 641 · see citing works

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617 · see citing works

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

Beck, L., Karaplis, A. C., Amizuka, N., Hewson, A. S., Ozawa, H., & Tenenhouse, H. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5372 · Cited by 607 · see citing works

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bonePreprint

Murshed, M., Harmey, D., Millán, J. L., McKee, M. D., & Karsenty, G. (2005) · Genes & Development · doi:10.1101/gad.1276205 · Cited by 599 · see citing works

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Chen, C.-D., Podvin, S., Gillespie, E., Leeman, S. E., & Abraham, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709805104 · Cited by 553 · see citing works

Identification of a Novel Fibroblast Growth Factor, FGF-23, Preferentially Expressed in the Ventrolateral Thalamic Nucleus of the Brain

Yamashita, T., Yoshioka, M., & Itoh, N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3696 · Cited by 553 · see citing works

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Goetz, R., Beenken, A., Ibrahimi, O., Kalinina, J., Olsen, S., Eliseenkova, A. V., Xu, C.-F., Neubert, T., Zhang, F.-M., Linhardt, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 544 · see citing works

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.

Sitara, D., Razzaque, M., Hesse, M., Yoganathan, S., Taguchi, T., Erben, R., Jüppner, H., & Lanske, B. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.09.007 · Cited by 528 · see citing works

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis

Lorenz‐Depiereux, B., Bastepe, M., Benet‐Pagès, A., Amyere, M., Wagenstaller, J., Mueller-Barth, U., Badenhoop, K. W. J., Kaiser, S., Rittmaster, R. S., Shlossberg, A. H., et al. (2006) · Nature Genetics · doi:10.1038/ng1868 · Cited by 528 · see citing works

Fibroblast Growth Factor-23 Relationship to Dietary Phosphate and Renal Phosphate Handling in Healthy Young Men

Ferrari, S. L., Bonjour, J.-P., & Rizzoli, R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1039 · Cited by 518 · see citing works

Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

Liu, S., Guo, R., Simpson, L. G., Xiao, Z.-S., Burnham, C. E., & Quarles, L. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304544200 · Cited by 505 · see citing works

Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis

Larsson, T. E., Marsell, R., Schipani, E., Ohlsson, C., Ljunggren, Ö., Tenenhouse, H. S., Jüppner, H., & Jonsson, K. B. (2004) · Endocrinology · doi:10.1210/en.2003-1768 · Cited by 497 · see citing works

Pathogenic role of Fgf23 in Hyp mice

Liu, S., Zhou, J., Tang, W., Jiang, X., Rowe, D. W., & Quarles, L. D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2006 · Cited by 494 · see citing works

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 490 · see citing works

An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

Benet-Pagès, A., Orlik, P., Strom, T., & Lorenz-Depiereux, B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi034 · Cited by 486 · see citing works

SLC34A3 Mutations in Patients with Hereditary Hypophosphatemic Rickets with Hypercalciuria Predict a Key Role for the Sodium-Phosphate Cotransporter NaPi-IIc in Maintaining Phosphate Homeostasis

Bergwitz, C., Roslin, N. M., Tieder, M., Loredo‐Osti, J., Bastepe, M., Abu-Zahra, H., Frappier, D., Burkett, K. M., Carpenter, T. O., Anderson, D., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/499409 · Cited by 485 · see citing works

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

Ichikawa, S., Imel, E. A., Kreiter, M. L., Yu, X., Mackenzie, D. S., Sorenson, A. H., Goetz, R. M., Mohammadi, M., White, K. E., & Econs, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31330 · Cited by 483 · see citing works

Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells

Krajisnik, T., Björklund, P., Marsell, R., Ljunggren, Ö., Åkerström, G., Jonsson, K. B., Westin, G., & Larsson, T. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0267 · Cited by 473 · see citing works

Circulating FGF-23 Is Regulated by 1α,25-Dihydroxyvitamin D3 and Phosphorus in Vivo

Saitô, H., Maeda, A., Ohtomo, S., Hirata, M., Kusano, K., Kato, S., Ogata, E., Segawa, H., Miyamoto, K., & Fukushima, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408903200 · Cited by 468 · see citing works

Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins

Fisher, L. W., & Fedarko, N. S. (2003) · Connective Tissue Research · doi:10.1080/03008200390152061 · Cited by 467 · see citing works

Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation.

Ma, Y. L., Cain, R. L., Halladay, D. L., Yang, X., Zeng, Q., Miles, R. R., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2001) · Endocrinology · doi:10.1210/endo.142.9.8356 · Cited by 428 · see citing works

Dietary and Serum Phosphorus Regulate Fibroblast Growth Factor 23 Expression and 1,25-Dihydroxyvitamin D Metabolism in Mice

Perwad, F., Azam, N., Zhang, M. Y. H., Yamashita, T., Tenenhouse, H. S., & Portale, A. A. (2005) · Endocrinology · doi:10.1210/en.2005-0777 · Cited by 424 · see citing works

Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1α,25-Dihydroxyvitamin D3 Production

Saitô, H., Kusano, K., Kinosaki, M., Ito, H., Hirata, M., Segawa, H., Miyamoto, K., & Fukushima, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207872200 · Cited by 412 · see citing works

Functional evolutionary history of the mouse Fgf gene family

Itoh, N., & Ornitz, D. M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21388 · Cited by 409 · see citing works

How Fibroblast Growth Factor 23 Works

Liu, S., & Quarles, L. D. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010068 · Cited by 407 · see citing works

Hypophosphatemia: an evidence-based approach to its clinical consequences and management

Amanzadeh, J., & Reilly, R. F. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0124 · Cited by 387 · see citing works

α-Klotho as a Regulator of Calcium Homeostasis

Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., et al. (2007) · Science · doi:10.1126/science.1135901 · Cited by 386 · see citing works

Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism

Shimada, T., Yamazaki, Y., Takahashi, M., Hasegawa, H., Urakawa, I., Oshima, T., Ono, K., Kakitani, M., Tomizuka, K., Fujita, T., et al. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00474.2004 · Cited by 359 · see citing works

Serum FGF23 Levels in Normal and Disordered Phosphorus Homeostasis

Weber, T. J., Liu, S., Indridason, Ó. S., & Quarles, L. D. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.7.1227 · Cited by 353 · see citing works

Immunohistochemical Localization of Klotho Protein in Brain, Kidney, and Reproductive Organs of Mice

Li, S.-A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M., & Takei, K. (2004) · Cell Structure and Function · doi:10.1247/csf.29.91 · Cited by 351 · see citing works

Premature aging‐like phenotype in fibroblast growth factor 23 null mice is a vitamin D‐mediated process

Razzaque, M. S., Sitara, D., Taguchi, T., St‐Arnaud, R., & Lanske, B. (2006) · The FASEB Journal · doi:10.1096/fj.05-5432fje · Cited by 345 · see citing works

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

Suzuki, M., Uehara, Y., Motomura-Matsuzaka, K., Oki, J., Koyama, Y., Kimura, M., Asada, M., Komi-Kuramochi, A., Oka, S., & Toru, T. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0313 · Cited by 345 · see citing works

FGF-23 Inhibits Renal Tubular Phosphate Transport and Is a PHEX Substrate

Bowe, A. E., Finnegan, R., de Beur, S. M. J., Cho, J., Levine, M. A., Kumar, R., & Schiavi, S. C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5084 · Cited by 339 · see citing works

Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

Masuyama, R., Stockmans, I., Torrekens, S., Looveren, R. V., Maes, C., Carmeliet, P., Bouillon, R., & Carmeliet, G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29463 · Cited by 332 · see citing works

Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders

Bai, X., Miao, D., Li, J., Goltzman, D., & Karaplis, A. C. (2004) · Endocrinology · doi:10.1210/en.2004-0233 · Cited by 329 · see citing works

Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.

White, K., Cabral, J., Davis, S. I., Fishburn, T., Evans, W. E., Ichikawa, S., Fields, J., Yu, X.-J., Shaw, N., McLellan, N., et al. (2005) · American Journal of Human Genetics · doi:10.1086/427956 · Cited by 320 · see citing works

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1

Shiraki-Iida, T., Aizawa, H., Matsumura, Y., Sekine, S., Iida, A., Anazawa, H., Nagai, R., Kuro‐o, M., & Nabeshima, Y.-I. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00127-6 · Cited by 309 · see citing works

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

Berndt, T. J., Craig, T. A., Bowe, A. E., Vassiliadis, J., Reczek, D., Finnegan, R., de Beur, S. M. J., Schiavi, S. C., & Kumar, R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18563 · Cited by 292 · see citing works

Liver-specific Activities of FGF19 Require Klotho beta

Lin, B. C., Wang, M., Blackmore, C. A., & Desnoyers, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704244200 · Cited by 284 · see citing works

Role of Hyperphosphatemia and 1,25-Dihydroxyvitamin D in Vascular Calcification and Mortality in Fibroblastic Growth Factor 23 Null Mice

Stubbs, J. R., Liu, S., Tang, W., Zhou, J., Wang, Y., Yao, X., & Quarles, L. D. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006121385 · Cited by 275 · see citing works

The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency

Bai, X., Miao, D., Goltzman, D., & Karaplis, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210490200 · Cited by 274 · see citing works

Mutations in SLC34A2 Cause Pulmonary Alveolar Microlithiasis and Are Possibly Associated with Testicular Microlithiasis

Corut, A., Şenyiğit, A., İşerı̇, S. A. U., Altın, S., Özçelik, U., Çalışır, H. C., Yıldırım, Z., Göçmen, A., & Tolun, A. (2006) · The American Journal of Human Genetics · doi:10.1086/508263 · Cited by 270 · see citing works

MEPE has the properties of an osteoblastic phosphatonin and minhibin

Rowe, P. S., Kumagai, Y., Gutierrez, G., Garrett, I. R., Blacher, R. W., Rosen, D., Cundy, J., Navvab, S., Chen, D., Drezner, M. K., et al. (2003) · Bone · doi:10.1016/j.bone.2003.10.005 · Cited by 268 · see citing works

Overexpression of Fibroblast Growth Factor 23 Suppresses Osteoblast Differentiation and Matrix Mineralization In Vitro

Wang, H., Yoshiko, Y., Yamamoto, R., Minamizaki, T., Kozai, K., Tanne, K., Aubin, J. E., & Maeda, N. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080220 · Cited by 263 · see citing works

FGF23 is processed by proprotein convertases but not by PHEX

Benet‐Pagès, A., Lorenz‐Depiereux, B., Zischka, H., White, K. E., Econs, M. J., & Strom, T. M. (2004) · Bone · doi:10.1016/j.bone.2004.04.002 · Cited by 258 · see citing works

Dual Functional Roles of Dentin Matrix Protein 1

Narayanan, K., Ramachandran, A., Hao, J. J., He, G., Park, K. W., Cho, M., & George, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212700200 · Cited by 243 · see citing works

Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men

Nishida, Y., Taketani, Y., Yamanaka-Okumura, H., Imamura, F., Taniguchi, A., Sato, T., Shuto, E., Nashiki, K., Arai, H., Yamamoto, H., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5002000 · Cited by 243 · see citing works

Alpha-Klotho as a regulator of calcium homeostasis

Tsuji, Y. (2008) · Kyoto University Research Information Repository (Kyoto University) · Cited by 241 · see citing works

Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in HomozygousklothoMutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene

Yoshida, T., Fujimori, T., & Nabeshima, Y. (2002) · Endocrinology · doi:10.1210/endo.143.2.8657 · Cited by 240 · see citing works

A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism

Brownstein, C. A., Adler, F., Nelson-Williams, C. J., Iijima, J., Li, P., Imura, A., Nabeshima, Y., Reyes‐Múgica, M., Carpenter, T. O., & Lifton, R. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712361105 · Cited by 239 · see citing works

Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.

Hafner, C., van Oers, J. V., Vogt, T., Landthaler, M., Stoehr, R., Blaszyk, H., Hofstaedter, F., Zwarthoff, E., & Hartmann, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28163 · Cited by 217 · see citing works

DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis

Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216 · see citing works

Fibroblast Growth Factor (FGF)-23 Inhibits Renal Phosphate Reabsorption by Activation of the Mitogen-activated Protein Kinase Pathway

Yamashita, T., Konishi, M., Miyake, A., Inui, K., & Itoh, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202527200 · Cited by 215 · see citing works

Analysis of the Biochemical Mechanisms for the Endocrine Actions of Fibroblast Growth Factor-23

Yu, X., Ibrahimi, O. A., Goetz, R. M., Zhang, F., Davis, S. I., Garringer, H. J., Linhardt, R. J., Ornitz, D. M., Mohammadi, M., & White, K. E. (2005) · Endocrinology · doi:10.1210/en.2005-0670 · Cited by 213 · see citing works

cDNA Cloning and Expression of a Novel Human UDP- -acetyl-α-D-galactosamine

Bennett, E., Hassan, H., & Clausen, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17006 · Cited by 211 · see citing works

Parathyroid Hormone Regulates Fibroblast Growth Factor-23 in a Mouse Model of Primary Hyperparathyroidism

Kawata, T., Imanishi, Y., Kobayashi, K., Miki, T., Arnold, A., Inaba, M., & Nishizawà, Y. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070783 · Cited by 208 · see citing works

Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice

Hesse, M., Fröhlich, L. F., Zeitz, U., Lanske, B., & Erben, R. G. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.10.003 · Cited by 198 · see citing works

Anti-FGF23 Neutralizing Antibodies Show the Physiological Role and Structural Features of FGF23

Yamazaki, Y., Tamada, T., Kasai, N., Urakawa, I., Aono, Y., Hasegawa, H., Fujita, T., Kuroki, R., Yamashita, T., Fukumoto, S., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080417 · Cited by 195 · see citing works

Genetic Evidence of Serum Phosphate-Independent Functions of FGF-23 on Bone

Sitara, D., Kim, S., Razzaque, M. S., Bergwitz, C., Taguchi, T., Schüler, C., Erben, R. G., & Lanske, B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000154 · Cited by 184 · see citing works

Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

Yuan, B., Takaiwa, M., Clemens, T. L., Feng, J. Q., Kumar, R., Rowe, P. S., Xie, Y., & Drezner, M. K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32702 · Cited by 178 · see citing works

Expression of SIBLINGs and Their Partner MMPs in Salivary Glands

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