Human ABC Transporter ABCG2 in Xenobiotic Protection and Redox Biology
Abstract
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2-drug interactions.
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ABCG2 is responsible for the cellular homeostasis of porphyrins and their related compounds.
“another ABC transporter ABCG2 is responsible for the cellular homeostasis of porphyrins and their related compounds [20].”
Cites
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Oxidized Redox State of Glutathione in the Endoplasmic Reticulum
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ABCG2-mediated transport of photosensitizers: Potential impact on photodynamic therapy
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Membrane transporters in drug development
The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340 · see citing works
Self-citationLipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
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Self-citation
- Authors
- Wakabayashi, K., Tamura, A., Saito, H., Onishi, Y., & Ishikawa, T.
- Affiliations
- Tokyo Institute of Technology (JP)
- ORCID
- Saito, Hikaru
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 38
- Issue
- 3
- Pages
- 371-391
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2160693601
- Cited by
- 66
- References
- 4
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Metabolism Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- ABCG2, ABC transporters, xenobiotic efflux, redox biology, disulfide bond formation, post-translational modification
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2, Amino Acid Sequence, Chlorophyll, Humans, Models, Biological, Molecular Sequence Data, Neoplasm Proteins, Oxidation-Reduction, Porphyrins, Xenobiotics, Gene Expression, ATP-Binding Cassette Transporters
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