Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
Open accessAbstract
ABCG2/BCRP is a member of the adenosine triphosphate–binding cassette (ABC) transporter family and is expressed in intestine, kidney, and liver, where it modulates the absorption and excretion of xenobiotic compounds. ABCG2 is also expressed in hematopoietic stem cells and erythroid cells; however, little is known regarding its role in hematopoiesis. Abcg2 null mice have increased levels of protoporphyrin IX (PPIX) in erythroid cells, yet the mechanism for this remains uncertain. We have found that Abcg2 mRNA expression was up-regulated in differentiating erythroid cells, coinciding with increased expression of other erythroid-specific genes. This expression pattern was associated with significant amounts of ABCG2 protein on the membrane of mature peripheral blood erythrocytes. Erythroid cells engineered to express ABCG2 had significantly lower intracellular levels of PPIX, suggesting the modulation of PPIX level by ABCG2. This modulating activity was abrogated by treatment with a specific ABCG2 inhibitor, Ko143, implying that PPIX may be a direct substrate for the transporter. Taken together, our results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG2 as a genetic determinant in erythropoietic protoporphyria.
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PpIX is an ABCG2 substrate.
“A subsequent study determined the effects of ABCG2 overexpression and transporter inhibition on intracellular and extracellular PpIX, providing compelling evidence that PpIX is an ABCG2 substrate [119].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [119]
Cites
Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1071 · Cited by 6,773 · see citing works
Thiebaut, F., TSURUO, T., Hamada, H., Gottesman, M. M., PASTAN, I., & Willingham, M. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7735 · Cited by 2,777 · see citing works
A multidrug resistance transporter from human MCF-7 breast cancer cells
Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T. A., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,319 · see citing works
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280 · see citing works
Self-citationThe Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C., Rzhetsky, A., & Allikmets, R. L. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,758 · see citing works
Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C. L. M., Schinkel, A. H., van de Vijver, M. J., Scheper, R. J., & Schellens, J. H. M. (2001) · PubMed · Cited by 1,130 · see citing works
The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C. (2001) · Genome Research · doi:10.1101/gr.gr-1649r · Cited by 1,127 · see citing works
Goodell, M. A., Rosenzweig, M., Kim, H. L., Marks, D. F., DeMaria, M., Paradis, G. A., Grupp, S. A., Sieff, C. A., Mulligan, R. C., & Johnson, R. P. (1997) · Nature Medicine · doi:10.1038/nm1297-1337 · Cited by 1,086 · see citing works
Jonker, J. W., Buitelaar, M., Wagenaar, E., van der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plösch, T., Kuipers, F., Elferink, R. P. J. O., Rosing, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202607599 · Cited by 822 · see citing works
Scharenberg, C. W., Harkey, M. A., & Torok‐Storb, B. (2002) · Blood · doi:10.1182/blood.v99.2.507 · Cited by 770 · see citing works
Allen, J. D., van Loevezijn, A., Rademaker-Lakhai, J. M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J. H. M., Koomen, G., & Schinkel, A. H. (2002) · PubMed · Cited by 690 · see citing works
Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan
Jonker, J. W. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.20.1651 · Cited by 639 · see citing works
Zhou, S., Morris, J. J., Barnes, Y., Lan, L.-B., Schuetz, J. D., & Sorrentino, B. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192276999 · Cited by 503 · see citing works
Self-citationOverview: ABC Transporters and Human Disease
Gottesman, M. M., & Ambudkar, S. V. (2001) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1012866803188 · Cited by 355 · see citing works
Allen, J. D., Brinkhuis, R. F., Wijnholds, J., & Schinkel, A. H. (1999) · PubMed · Cited by 353 · see citing works
Kina, T., Ikuta, K., Takayama, E., Wada, K., Sen-Majumdar, A., Weissman, I. L., & Katsura, Y. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02037.x · Cited by 350 · see citing works
Robey, R. W., Medina-Pérez, W. Y., Nishiyama, K., Lahusen, T. J., Miyake, K., Litman, T., Senderowicz, A. M., Ross, D. D., & Bates, S. E. (2001) · PubMed · Cited by 341 · see citing works
Zamber, C. P., Lamba, J. K., Yasuda, K., Farnum, J., Thummel, K. E., Schuetz, J. D., & Schuetz, E. G. (2003) · Pharmacogenetics · doi:10.1097/00008571-200301000-00004 · Cited by 272 · see citing works
Erythropoietic protoporphyria 10 years experience
DeLeo, V. A., Poh‐Fitzpatrick, M. B., Mathews‐Roth, M. M., & Harber, L. C. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90528-3 · Cited by 187 · see citing works
ABC‐me: a novel mitochondrial transporter induced by GATA‐1 during erythroid differentiation
Shirihai, O. S., Gregory, T., Yu, C., Orkin, S. H., & Weiss, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2492 · Cited by 154 · see citing works
Koury, M. J., Sawyer, S. T., & Bondurant, M. C. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041210311 · Cited by 145 · see citing works
Genetic aspects of erythropoietic protoporphyria
Went, L. N., & Klasen, E. C. (1984) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1984.tb01006.x · Cited by 135 · see citing works
Tutois, S., Montagutelli, X., Silva, V. D., Jouault, H., Rouyer‐Fessard, P., Leroy, K., Jl, G., NORDMANN, Y., Beuzard, Y., & Deybach, J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115491 · Cited by 133 · see citing works
Low levels of ABCG2 expression in adult AML blast samples
Abbott, B. L., Colapietro, A.-M., Barnes, Y., Marini, F. C., Andreeff, M., & Sorrentino, B. P. (2002) · Blood · doi:10.1182/blood-2002-01-0271 · Cited by 121 · see citing works
Self-citationFerreira, G. C., Andrew, T. L., Karr, S. W., & Dailey, H. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69000-3 · Cited by 119 · see citing works
Human Erythropoietic Protoporphyria: Two point mutations in the ferrochelatase gene
Lamoril, J., Boulechfar, S., de Verneuil, H., Grandchamp, B., NORDMANN, Y., & Deybach, J. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91231-z · Cited by 113 · see citing works
Zhou, S., Zong, Y., Lu, T., & Sorrentino, B. P. (2003) · BioTechniques · doi:10.2144/03356ss04 · Cited by 57 · see citing works
Self-citationMagness, S. T., Maeda, N., & Brenner, D. A. (2002) · Blood · doi:10.1182/blood-2001-12-0283 · Cited by 55 · see citing works
Gederaas, O. A., Berg, K., & Romslo, I. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00399-7 · Cited by 21 · see citing works
Allelic imbalance within the E-cadherin gene is an infrequent event in prostate carcinogenesis
Murant, S. J., Rolley, N., Phillips, S. M. A., Stower, M. J., & Maitland, N. J. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200001)27:1 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update
Mao, Q., & Unadkat, J. D. (2014) · The AAPS Journal · doi:10.1208/s12248-014-9668-6 · Cited by 676 · see citing works
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
Chiabrando, D., Vinchi, F., Fiorito, V., Mercurio, S., & Tolosano, E. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00061 · Cited by 455 · see citing works
Chemotherapy-induced resistance by ATP-binding cassette transporter genes
Gillet, J. A., Efferth, T., & Remacle, J. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.05.002 · Cited by 336 · see citing works
Liu, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_2 · Cited by 263 · see citing works
Protoporphyrin IX: the Good, the Bad, and the Ugly
Sachar, M., Anderson, K. E., & Ma, X. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228130 · Cited by 259 · see citing works
Multidrug resistance: Physiological principles and nanomedical solutions
Kunjachan, S., Rychlik, B., Storm, G., Kiessling, F. M., & Lammers, T. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.018 · Cited by 259 · see citing works
Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice
Vlaming, M. L. H., Lagas, J. S., & Schinkel, A. H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.007 · Cited by 244 · see citing works
The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy
Wu, C., Hsieh, C., & Wu, Y. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200261n · Cited by 232 · see citing works
Liu, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_3 · Cited by 224 · see citing works
Human ABCG2: structure, function, and its role in multidrug resistance.
Mo, W., & Zhang, J. (2012) · PubMed Central · Cited by 218 · see citing works
Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy
Tiwari, A. K., Sodani, K. S., Dai, C., Ashby, C. R., & Chen, Z. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111795164048 · Cited by 211 · see citing works
Control of intracellular heme levels: Heme transporters and heme oxygenases
Khan, A., & Quigley, J. G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.008 · Cited by 191 · see citing works
Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications
Toyoda, Y., Takada, T., & Suzuki, H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00208 · Cited by 155 · see citing works
ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis
Helias, V., Saison, C., Ballif, B. A., Peyrard, T., Takahashi, J., Takahashi, H. K., Tanaka, M., Deybach, J., Puy, H., Gall, M. L., et al. (2012) · Nature Genetics · doi:10.1038/ng.1069 · Cited by 147 · see citing works
Tamura, A., Watanabe, M., Saito, H., Nakagawa, H., Kamachi, T., Okura, I., & Ishikawa, T. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023556 · Cited by 141 · see citing works
Regulation of phospholipid asymmetry in the erythrocyte membrane
Daleke, D. L. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f97af7 · Cited by 136 · see citing works
Emerging new paradigms for ABCG transporters
Tarr, P. T., Tarling, E. J., Bojanic, D. D., Edwards, P. A., & Baldán, Á. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.007 · Cited by 122 · see citing works
Saison, C., Helias, V., Ballif, B. A., Peyrard, T., Puy, H., Miyazaki, T., Perrot, S., Vayssier‐Taussat, M., Waldner, M., Pennec, P. L., et al. (2012) · Nature Genetics · doi:10.1038/ng.1070 · Cited by 120 · see citing works
ABC Transporters and Drug Efflux at the Blood-Brain Barrier
Shen, S., & Zhang, W. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.1.29 · Cited by 120 · see citing works
Multidrug efflux transporter ABCG2: expression and regulation
Kukal, S., Guin, D., Rawat, C., Bora, S., Mishra, M., Sharma, P., Paul, P. R., Kanojia, N., Grewal, G. K., Kukreti, S., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03901-y · Cited by 119 · see citing works
Hagiya, Y., Endo, Y., Yonemura, Y., Takahashi, K., Ishizuka, M., Abe, F., Tanaka, T., Okura, I., Nakajima, M., Ishikawa, T., et al. (2012) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2011.12.004 · Cited by 115 · see citing works
Recent advances in mammalian haem transport
Latunde-Dada, G. O., Simpson, R. J., & McKie, A. T. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.01.005 · Cited by 113 · see citing works
ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer
van de Ven, R., Oerlemans, R., van der Heijden, J. W., Scheffer, G. L., de Gruijl, T. D., Jansen, G., & Scheper, R. J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309147 · Cited by 107 · see citing works
Köck, K., Grube, M., Jedlitschky, G., Oevermann, L., Siegmund, W., Ritter, C. A., & Kroemer, H. K. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746060-00001 · Cited by 105 · see citing works
Zhao, S., Chen, X., Wang, L.-G., Yang, G., Han, D., Teng, L., Yang, M., Wang, D.-Y., Shi, C., Liu, Y.-H., et al. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-011-2201-6 · Cited by 105 · see citing works
ABCG2 Transports and Transfers Heme to Albumin through Its Large Extracellular Loop*
Mandon, E. D., Arnaud, O., Martinez, L., Huché, F., Pietro, A. D., & Falson, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139170 · Cited by 98 · see citing works
Zattoni, I. F., Delabio, L. C., Dutra, J. D. P., Kita, D. H., Scheiffer, G., Hembecker, M., Pereira, G. D. S., Moure, V. R., & Valdameri, G. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114346 · Cited by 88 · see citing works
zu Schwabedissen, H. E. M., & Kroemer, H. K. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-14541-4_9 · Cited by 89 · see citing works
Heyes, N., Kapoor, P., & Kerr, I. D. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.083030 · Cited by 86 · see citing works
Clough, C. A., Pangallo, J., Sarchi, M., Ilagan, J. O., North, K., Bergantinos, R., Stolla, M. C., Naru, J., Nugent, P., Kim, E. H., et al. (2021) · Blood · doi:10.1182/blood.2021012652 · Cited by 86 · see citing works
One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers
Chambers, I. G., Willoughby, M. M., Hamza, I., & Reddi, A. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118881 · Cited by 73 · see citing works
Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics
Jani, M., Temesszentandrási‐Ambrus, C., Magnan, R., Jakab, K. T., Beéry, E., Zolnerciks, J. K., & Krajcsi, P. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1224-8 · Cited by 74 · see citing works
Maitra, D., Cunha, J. B., Elenbaas, J. S., Bonkovsky, H. L., Shavit, J. A., & Omary, M. B. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.06.006 · Cited by 74 · see citing works
Tamura, A., Onishi, Y., An, R., Koshiba, S., Wakabayashi, K., Hoshijima, K., Priebe, W., Yoshida, T., Kometani, S., Matsubara, T., et al. (2007) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.22.428 · Cited by 72 · see citing works
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2)
Hardwick, L. J. A., Velamakanni, S., & van Veen, H. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707218 · Cited by 71 · see citing works
Do Mammalian Cells Really Need to Export and Import Heme?
Ponka, P., Sheftel, A. D., English, A. M., Bohle, D. S., & Garcia‐Santos, D. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.01.006 · Cited by 64 · see citing works
Human ABC Transporter ABCG2 in Xenobiotic Protection and Redox Biology
Wakabayashi, K., Tamura, A., Saito, H., Onishi, Y., & Ishikawa, T. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600727947 · Cited by 66 · see citing works
Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells
Ogino, T., Kobuchi, H., Munetomo, K., Fujita, H., Yamamoto, M., Utsumi, T., Inoue, K., Shuin, T., Sasaki, J., Inoue, M., et al. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0980-5 · Cited by 63 · see citing works
Kosztyu, P., Bukvova, R., Doležel, P., & Mlejnek, P. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.06.009 · Cited by 61 · see citing works
Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
Yoshioka, E., Chelakkot, V. S., Licursi, M., Rutihinda, S. G., Som, J., Derwish, L., King, J. J., Pongnopparat, T., Mearow, K. M., Larijani, M., et al. (2018) · Theranostics · doi:10.7150/thno.22641 · Cited by 60 · see citing works
Fatima, S., Zhou, S., & Sorrentino, B. P. (2011) · Stem Cells · doi:10.1002/stem.1002 · Cited by 59 · see citing works
Self-citationKitajima, Y., Ishii, T., Kohda, T., Ishizuka, M., Yamazaki, K., Nishimura, Y., Tanaka, T., Dan, S., & Nakajima, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44981-y · Cited by 56 · see citing works
Dankers, A. C. A., Sweep, F. C. G. J., Pertijs, J. C. L. M., Verweij, V. G. M., van den Heuvel, J. J. M. W., Koenderink, J. B., Rüssel, F. G. M., & Masereeuw, R. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1417-5 · Cited by 55 · see citing works
Cancer Stem Cells: A Review of Potential Clinical Applications
Podberezin, M., Wen, J., & Chang, C.-C. (2012) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012-0494-ra · Cited by 52 · see citing works
Ishikawa, T., Tamura, A., Saito, H., Wakabayashi, K., & Nakagawa, H. (2005) · Die Naturwissenschaften · doi:10.1007/s00114-005-0019-4 · Cited by 51 · see citing works
Mosaffa, F., Lage, H., Afshari, J. T., & Behravan, J. (2009) · Inflammation Research · doi:10.1007/s00011-009-0034-6 · Cited by 50 · see citing works
A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells
Kiening, M., & Lange, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147974 · Cited by 48 · see citing works
The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria
Wang, P., Sachar, M., Lu, J. L., Shehu, A. I., Zhu, J., Chen, J., Liu, K., Anderson, K. E., Xie, W., Gonzalez, F. J., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw6127 · Cited by 49 · see citing works
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6
Fukuda, Y., Cheong, P. L., Lynch, J., Brighton, C. A., Frase, S., Kargas, V. E., Rampersaud, E., Wang, Y., Sankaran, V. G., Yu, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12353 · Cited by 47 · see citing works
Self-citationHuman ABC transporters ABCG2 (BCRP) and ABCG4
Koshiba, S., An, R., Saito, H., Wakabayashi, K., Tamura, A., & Ishikawa, T. (2008) · Xenobiotica · doi:10.1080/00498250801986944 · Cited by 47 · see citing works
Kasza, I., Várady, G., Andrikovics, H., Koszarska, M., Tordai, A., Scheffer, G. L., Németh, A., Szakács, G., & Sarkadi, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048423 · Cited by 44 · see citing works
ABCG2 transporter: therapeutic and physiologic implications in veterinary species
Mealey, K. L. (2011) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2011.01313.x · Cited by 44 · see citing works
Transporter-mediated uptake into cellular compartments
Oswald, S., Grube, M., Siegmund, W., & Kroemer, H. K. (2007) · Xenobiotica · doi:10.1080/00498250701570251 · Cited by 41 · see citing works
Differential Sensitivity in Cell Lines to Photodynamic Therapy in Combination with ABCG2 Inhibition
Barron, G. A., Moseley, H., & Woods, J. A. (2013) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2013.07.003 · Cited by 40 · see citing works
ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Morfouace, M., Cheepala, S., Jackson, S., Fukuda, Y., Patel, Y. T., Fatima, S., Kawauchi, D., Shelat, A. A., Stewart, C. F., Sorrentino, B. P., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0030 · Cited by 39 · see citing works
Self-citationEstablishment of Metabolism and Transport Pathways in the Rodent and Human Fetal Liver
Moscovitz, J. E., & Aleksunes, L. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141223801 · Cited by 39 · see citing works
Abitbol, M., Bernex, F., Puy, H., Jouault, H., Deybach, J., Guénet, J., & Montagutelli, X. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00505.2004 · Cited by 39 · see citing works
ABCG2 (BCRP): a cytoprotectant in normal and malignant stem cells.
Abbott, B. L. (2006) · PubMed · Cited by 39 · see citing works
Heme Scavenging and Delivery: The Role of Human Serum Albumin
Simone, G. D., Varricchio, R., Ruberto, T. F., di Masi, A., & Ascenzi, P. (2023) · Biomolecules · doi:10.3390/biom13030575 · Cited by 36 · see citing works
Prospective Isolation of Murine Hematopoietic Stem Cells by Expression of an Abcg2/GFP Allele
Tadjali, M., Zhou, S., Rehg, J. E., & Sorrentino, B. P. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0562 · Cited by 38 · see citing works
Self-citationLi, G., Chen, S., Duan, Z., Qu, L., Xu, G., & Yang, N. (2013) · Poultry Science · doi:10.3382/ps.2013-03484 · Cited by 37 · see citing works
Molecular insights into the human ABCB6 transporter
Song, G., Zhang, S., Tian, M., Zhang, L., Guo, R., Zhuo, W., & Yang, M. (2021) · Cell Discovery · doi:10.1038/s41421-021-00284-z · Cited by 35 · see citing works
Mazurek, M., Szczepanek, D., Orzyłowska, A., & Rola, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020926 · Cited by 33 · see citing works
Zong, Y., Zhou, S., Fatima, S., & Sorrentino, B. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606314200 · Cited by 35 · see citing works
Self-citationMedically Important Alterations in Transport Function and Trafficking of ABCG2
Homolya, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062786 · Cited by 34 · see citing works
5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
Howley, R., Chandratre, S., & Chen, B. (2023) · Bioengineering · doi:10.3390/bioengineering10040496 · Cited by 33 · see citing works
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications
Sakurai, A., Tamura, A., Onishi, Y., & Ishikawa, T. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.14.2455 · Cited by 32 · see citing works
Jonker, J. W., Musters, S., Vlaming, M. L. H., Plösch, T., Gooijert, K. E. R., Hillebrand, M. J. X., Rosing, H., Beijnen, J. H., Verkade, H. J., & Schinkel, A. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00359.2006 · Cited by 32 · see citing works
Chandratre, S., Olsen, J., Howley, R., & Chen, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115851 · Cited by 30 · see citing works
Determinants of the activity and substrate recognition of breast cancer resistance protein (ABCG2)
Szafraniec, M., Szczygieł, M., Urbańska, K., & Fiedor, L. (2014) · Drug Metabolism Reviews · doi:10.3109/03602532.2014.942037 · Cited by 30 · see citing works
Ahmed, F., Arseni, N., Glimm, H., Hiddemann, W., Buske, C., & Feuring‐Buske, M. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0527 · Cited by 30 · see citing works
Establishment and characterization of rat dental epithelial derived ameloblast-lineage clones
Abe, K., Miyoshi, K., Muto, T., Ruspita, I., Horiguchi, T., Nagata, T., & Noma, T. (2007) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.103.479 · Cited by 30 · see citing works
Wang, H., Ge, Y. C., Zhang, L. J., Wei, Y., Li, Q., Zhang, X., & Pan, Y. (2023) · animal · doi:10.1016/j.animal.2023.100776 · Cited by 29 · see citing works
Gnana‐Prakasam, J. P., Reddy, S. K., Veeranan‐Karmegam, R., Smith, S. B., Martin, P. M., & Ganapathy, V. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8264 · Cited by 29 · see citing works
Zeng, H., Chen, J., Chen, X., Li, Y.-Z., Chen, G., Huang, Z., & Chen, R. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.4.861 · Cited by 26 · see citing works
Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2
Dutta, R., Zhang, T. Y., Köhnke, T., Thomas, D., Linde, M. H., Gars, E. J., Stafford, M., Kaur, S., Nakauchi, Y., Yin, R. R., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133344 · Cited by 26 · see citing works
The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation
Miura, M., Ito, K., Hayashi, M., Nakajima, M., Tanaka, T., & Ogura, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131793 · Cited by 26 · see citing works
Chen, L., Gu, X., Huang, X., Liu, R., Li, J., Hu, Y., Li, G., Zeng, T., Tian, Y., Hu, X., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009119 · Cited by 24 · see citing works
ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer
Leimanis, M. L., & Georges, E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.219 · Cited by 23 · see citing works
Samiullah, S., Roberts, J. R., & Wu, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-06527-y · Cited by 23 · see citing works
Trajectory inference from single-cell genomics data with a process time model
Fang, M., Gorin, G., & Pachter, L. S. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012752 · Cited by 20 · see citing works
Intracellular Retention of ABL Kinase Inhibitors Determines Commitment to Apoptosis in CML Cells
Lipka, D. B., Wagner, M., Dziadosz, M., Schnoeder, T. M., Heidel, F. H., Schemionek, M., Melo, J. V., Kindler, T., Müller‐Tidow, C., Koschmieder, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040853 · Cited by 21 · see citing works
Yamamoto, M., Fujita, H., Katase, N., Inoue, K., Nagatsuka, H., Utsumi, K., Sasaki, J., & Ohuchi, H. (2013) · PubMed · doi:10.18926/amo/50408 · Cited by 21 · see citing works
Egan, E. S., Weekes, M. P., Kanjee, U., Manzo, J., Srinivasan, A., Lomas, C., Westhoff, C. M., Takahashi, J., Tanaka, M., Watanabe, S., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0046-2 · Cited by 20 · see citing works
Heme Oxygenase-1 and Breast Cancer Resistance Protein Protect Against Hemeinduced Toxicity
Wagener, F. A. D. T. G., Dankers, A. C. A., van Summeren, F., Scharstuhl, A., van den Heuvel, J. J. M. W., Koenderink, J. B., Pennings, S. W. C., Rüssel, F. G. M., & Masereeuw, R. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319150004 · Cited by 20 · see citing works
Implication of ABC transporters in non-proliferative diseases
Grigoreva, T. A., Sagaidak, A. V., Novikova, D., & Tribulovich, V. G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175327 · Cited by 19 · see citing works
How I treat erythropoietic protoporphyria and X-linked protoporphyria
Leaf, R. K., & Dickey, A. K. (2023) · Blood · doi:10.1182/blood.2022018688 · Cited by 19 · see citing works
Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia
Nagy, B. M., Nagaraj, C., Egemnazarov, B., Kwapiszewska, G., Stauber, R. E., Avian, A., Olschewski, H., & Olschewski, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00098 · Cited by 21 · see citing works
Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria
Rommelaere, S., Millet, V., Rihet, P., Atwell, S. X., Helfer, E., Chasson, L., Beaumont, C., Chimini, G., Sambo, M. D. R., Viallat, A., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.07.011 · Cited by 18 · see citing works
Identification of crucial genes and metabolites regulating the eggshell brownness in chicken
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · BMC Genomics · doi:10.1186/s12864-022-08987-7 · Cited by 17 · see citing works
ABCG2: does resolving its structure elucidate the mechanism?
Kapoor, P., Horsey, A. J., Cox, M. H., & Kerr, I. D. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180145 · Cited by 17 · see citing works
Kushibiki, T., Sakai, M., & Awazu, K. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.054 · Cited by 17 · see citing works
Roles of the ABCG2 Transporter in Protoporphyrin IX Distribution and Toxicity
Qi, Q., Gu, R., Zhu, J., Anderson, K. E., & Ma, X. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.123.001582 · Cited by 16 · see citing works
Wang, C., Chen, X., Wu, J., Liu, H., Ji, Z., Shi, H., Gao, C., Han, D., Wang, L., Liu, Y., et al. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.06.001 · Cited by 16 · see citing works
Tamura, A., An, R., Hagiya, Y., Hoshijima, K., Yoshida, T., Mikuriya, K., & Ishikawa, T. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.3.255 · Cited by 16 · see citing works
An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice
García-Mateos, D., Garcı́a-Villalba, R., Otero, J. A., Marañón, J. A., Espı́n, J. C., Álvarez, A. I., & Merino, G. (2017) · Food & Function · doi:10.1039/c7fo01549f · Cited by 14 · see citing works
Erythropoietic protoporphyrias: updates and advances
Poli, A., Schmitt, C., Puy, H., Talbi, N., Lefèbvre, T., & Gouya, L. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.05.006 · Cited by 13 · see citing works
Postiglione, I., Barra, F., Aloj, S. M., & Palumbo, G. A. (2016) · Cell Proliferation · doi:10.1111/cpr.12274 · Cited by 13 · see citing works
Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors
Zhu, J., Lei, S., Lu, J. L., Hao, Y., Qian, Q., Devanathan, A. S., Feng, Z., Xie, X., Wipf, P., & Ma, X. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115666 · Cited by 12 · see citing works
Fujita, S., Kashiwagi, H., Tomimatsu, T., Ito, S., Mimura, K., Kanagawa, T., Endo, M., Miyoshi, T., Okamura, Y., Tani, Y., et al. (2016) · Transfusion · doi:10.1111/trf.13515 · Cited by 12 · see citing works
- Authors
- Zhou, S., Zong, Y., Ney, P. A., Nair, G., Stewart, C. F., & Sorrentino, B. P.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-15
- Volume
- 105
- Issue
- 6
- Pages
- 2571-2576
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4757428
- OpenAlex
- W1977748061
- Cited by
- 157
- References
- 31
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL067366, R01-HL67366)
- National Cancer Institute (R01CA084214)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ABCG2, ABC transporters, erythroid maturation, protoporphyrin IX, erythropoiesis, Ko143, erythropoietic protoporphyria, erythrocyte membrane, hematopoiesis, gene expression regulation
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Biological Transport, Cell Differentiation, Enzyme Inhibitors, Erythrocyte Membrane, Erythropoiesis, Humans, Intestinal Mucosa, Kidney, Liver, Organ Specificity, Protoporphyrins, Mice, Knockout, ATP-Binding Cassette Transporters, K562 Cells, Protoporphyria, Erythropoietic, Mice
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