Development, In Vitro and In Vivo Evaluation of Hydrogel Based System of Carboxymethyl Arabinoxylan for Controlled Delivery of Rabeprazole Sodium
Abstract
Present study deals with development of polymeric systems for rabeprazole sodium to accomplish a lingering therapeutic outcome. Carboxymethyl arabinoxylan exhibited variety of ideal characteristics for polymeric drug carrier. Free radical polymerization was successfully employed to prepare pH responsive polymeric network of carboxymethyl arabinoxylan with acrylic acid. FTIR, SEM, thermogravimetric analysis and X-ray diffraction verified the graft copolymerization. Graft copolymers revealed highly pH responsive swelling, consequently drug release at intestinal pH. In vivo evaluation indicated improvement in relative bioavailability by exhibiting increase in Cmax of polymeric system and same oral dose of rabeprazole sodium were 103.71 ± 16.081 and 61.263 ± 5.37 ng/mL, respectively.
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Equilibrium swelling of PAG-co-AA hydrogels decreased by increasing MBA concentration.
“Like dynamic swelling equilibrium swelling was also increased by increasing AA and PAG and decreased by increasing MBA (U.R. Tulain et al., 2018).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as U.R. Tulain et al., 2018
Dynamic swelling ratio at pH 1.2 increased from 4.98 to 6.14 with increasing acrylic acid concentration.
“Dynamic swelling was also increased in pH 1.2 medium from 4.98 to 6.14 as reported earlier (U.R. Tulain et al., 2018).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as U.R. Tulain et al., 2018
Equilibrium swelling of PAG-co-AA hydrogels increased by increasing PAG concentration.
“Like dynamic swelling equilibrium swelling was also increased by increasing AA and PAG and decreased by increasing MBA (U.R. Tulain et al., 2018).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as U.R. Tulain et al., 2018
Equilibrium swelling of PAG-co-AA hydrogels increased by increasing acrylic acid concentration.
“Like dynamic swelling equilibrium swelling was also increased by increasing AA and PAG and decreased by increasing MBA (U.R. Tulain et al., 2018).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as U.R. Tulain et al., 2018
Cited by
Sorted by citations
Noureen, S., Noreen, S., Ghumman, S. A., Abdelrahman, E. A., Batool, F., Aslam, A., Mehdi, M., Shirinfar, B., & Ahmed, N. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106555 · Cited by 28 · see citing works
Kausar, S., Erum, A., Tulain, U. R., Hussain, M. A., Farid-ul-Haq, M., Malik, N. S., & Rashid, A. (2021) · Advances in Polymer Technology · doi:10.1155/2021/6634780 · Cited by 7 · see citing works
Self-citation
- Authors
- Tulain, U. R., Ahmad, M., & Rashid, A.
- Affiliations
- University of Sargodha (PK)
- Islamia University of Bahawalpur (PK)
- The Women University Multan (PK)
- Corresponding author
- Tulain, Ume Ruqia
- Venue
- Polymer-Plastics Technology and Engineering
- Publisher
- Informa UK Limited
- Published
- 2018-02-20
- Volume
- 57
- Issue
- 17
- Pages
- 1771-1783
- ISSN
- 0360-2559 (ISSN-L)
- 1525-6111
- OpenAlex
- W2791058253
- Cited by
- 16
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer-Plastics Technology and Engineering (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- rabeprazole sodium, hydrogels, controlled drug release, pH-responsive polymers, graft copolymerization, acrylic acid, radical polymerization, relative bioavailability, oral drug delivery, gastroretentive drug delivery
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