Review and analysis of FDA approved drugs using lipid-based formulations

Savla, Ronak; Browne, Jeff; Plassat, Vincent; Wasan, Kishor M.; Wasan, Ellen K.

doi:10.1080/03639045.2017.1342654

Cited by 225Drug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAdvancements in Transdermal Drug Delivery

Review and analysis of FDA approved drugs using lipid-based formulations

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Savla, Ronak, Browne, Jeff, Plassat, Vincent, Wasan, Kishor M., Wasan, Ellen K.·2017·Drug Development and Industrial Pharmacy

DOI 10.1080/03639045.2017.1342654

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Abstract

Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability enhancement technologies and are utilized in a number of U.S. Food and Drug Administration (FDA) approved drugs. While researchers have used several general rules of thumb to predict which compounds are likely to benefit from LBDDS, formulation of lipid systems is primarily an empiric endeavor. One of the challenges is that these rules of thumb focus in different areas and are used independently of each other. The Developability Classification System attempts to link physicochemical characteristics with possible formulation strategies. Although it provides a starting point, the formulator still has to empirically develop the formulation. This article provides a review and quantitative analysis of the molecular properties of these approved drugs formulated as lipid systems and starts to build an approach that provides more directed guidance on which type of lipid system is likely to be the best for a particular drug molecule.

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Lipid-based drug delivery systems improve oral absorption of poorly water-soluble drugs through mechanisms including increasing solubility, reducing food-induced exposure variability and improving overall intestinal uptake.
“With numerous commercial successes, lipid-based drug delivery systems (LBDDS) have a proven track record to improve oral absorption of poorly water-soluble drugs (PWSDs) through a variety of mechanisms including increasing solubility, reducing food-induced exposure variability and improving overall intestinal uptake (Savla et al., 2017).”
From Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption (2020) · cites this paper as Savla et al., 2017

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139 · see citing works
Molecular properties that influence the oral bioavailability of drug candidates
Veber, D. F., Johnson, S. R., Cheng, H.-Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020017n · Cited by 8,420 · see citing works
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430 · see citing works
DrugBank: a comprehensive resource for in silico drug discovery and exploration
Wishart, D. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj067 · Cited by 3,892 · see citing works
The influence of drug-like concepts on decision-making in medicinal chemistry
Leeson, P. D., & Springthorpe, B. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2445 · Cited by 2,403 · see citing works
Lipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
Porter, C. J. H., Trevaskis, N. L., & Charman, W. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2197 · Cited by 1,824 · see citing works
Solubilizing Excipients in Oral and Injectable Formulations
Strickley, R. G. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000016235.32639.23 · Cited by 1,417 · see citing works
Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
Pouton, C. W. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.04.016 · Cited by 1,306 · see citing works
Arzneimittelforschung
(2017) · Arzneimittelforschung · doi:10.1055/s-00000175 · Cited by 1,134 · see citing works
Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies
Pouton, C. W., & Porter, C. J. H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.010 · Cited by 887 · see citing works
Oral lipid-based formulations
Hauss, D. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.006 · Cited by 597 · see citing works
Handbook of Aqueous Solubility Data
Yalkowsky, S. H. (2003) · CRC Press eBooks · doi:10.1201/9780203490396 · Cited by 586 · see citing works
Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration
Fleisher, D., Li, C., Zhou, Y., Pao, L., & Karim, A. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199936030-00004 · Cited by 507 · see citing works
ChemMine tools: an online service for analyzing and clustering small molecules
Backman, T. W. H., Cao, Y., & Girke, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr320 · Cited by 502 · see citing works
Lipid-Based Delivery Systems and Intestinal Lymphatic Drug Transport: A Mechanistic Update
Trevaskis, N. L., Charman, W. N., & Porter, C. J. H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.007 · Cited by 442 · see citing works
The Developability Classification System: Application of Biopharmaceutics Concepts to Formulation Development
Butler, J., & Dressman, J. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22217 · Cited by 426 · see citing works
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Feeney, O. M., Crum, M. F., McEvoy, C. L., Trevaskis, N. L., Williams, H. D., Pouton, C. W., Charman, W. N., Bergström, C. A. S., & Porter, C. J. H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.007 · Cited by 426 · see citing works
Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics†
Wacher, V. J., Silverman, J. A., Zhang, Y., & Benet, L. Z. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980082d · Cited by 423 · see citing works
Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles.
Martins, S., Sarmento, B. F. C. C., Ferreira, D., & Souto, E. B. (2007) · PubMed Central · Cited by 399 · see citing works
Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs
Dahan, A., & Hoffman, A. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.03.021 · Cited by 343 · see citing works
Absorption Enhancement through Intracellular Regulation of Tight Junction Permeability by Medium Chain Fatty Acids in Caco-2 Cells
Lindmark, T., Kimura, Y., & Artursson, P. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37216-7 · Cited by 333 · see citing works
Absorption Enhancers: Applications and Advances
Aungst, B. J. (2011) · The AAPS Journal · doi:10.1208/s12248-011-9307-4 · Cited by 309 · see citing works
Amphotericin B
Lemke, A., Kiderlen, A. F., & Kayser, O. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-1955-9 · Cited by 307 · see citing works
New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
Müllertz, A., Ogbonna, A., Ren, S., & Rades, T. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01107.x · Cited by 295 · see citing works
Intestinal lymphatic transport for drug delivery
Yáñez, J. A., Wang, S. W. J., Knemeyer, I. W., Wirth, M., & Alton, K. B. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.019 · Cited by 280 · see citing works
The effect of different lipid based formulations on the oral absorption of lipophilic drugs: The ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats
Dahan, A., & Hoffman, A. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.01.017 · Cited by 232 · see citing works
Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs
Čerpnjak, K., Pobirk, A. Z., Gašperlin, M., & Vrečer, F. (2013) · Acta Pharmaceutica · doi:10.2478/acph-2013-0040 · Cited by 227 · see citing works
Unusual lipid structures selectively reduce the toxicity of amphotericin B.
Janoff, A. S., Boni, L. T., Popescu, M. C., Minchey, S. R., Cullis, P. R., Madden, T. D., Taraschi, T. F., Gruner, S. M., Shyamsunder, E., & Täte, M. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.6122 · Cited by 223 · see citing works
Influence of lipolysis on drug absorption from the gastro-intestinal tract
MacGregor, K. J., Embleton, J. K., Lacy, J. E., Perry, E., Solomon, L. J., Seager, H., & Pouton, C. W. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(96)00489-9 · Cited by 220 · see citing works
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine
Porter, C. J. H., Kaukonen, A. M., Taillardat‐Bertschinger, A., Boyd, B. J., O'Connor, J. M., Edwards, G. A., & Charman, W. N. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20039 · Cited by 216 · see citing works
REDUCED INTER- AND INTRASUBJECT VARIABILITY IN CYCLOSPORINE PHARMACOKINETICS IN RENAL TRANSPLANT RECIPIENTS TREATED WITH A MICROEMULSION FORMULATION IN CONJUNCTION WITH FASTING, LOW-FAT MEALS, OR HIGH-FAT MEALS1,2
Kahan, B. D., Dunn, J. L., Fitts, C. T., Buren, D. V., Wombolt, D. G., Pollak, R., Carson, R. W., Alexander, W. J., Choc, M. G., Wong, R., et al. (1995) · Transplantation · doi:10.1097/00007890-199502270-00011 · Cited by 215 · see citing works
Lipid Formulation Strategies for Enhancing Intestinal Transport and Absorption of P-Glycoprotein (P-gp) Substrate Drugs: In vitro/In vivo Case Studies
Constantinides, P. P., & Wasan, K. M. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20780 · Cited by 209 · see citing works
Self-citation
ADME Evaluation in Drug Discovery. 5. Correlation of Caco-2 Permeation with Simple Molecular Properties
Hou, T., Zhang, W., Xia, K., Qiao, X. B., & Xu, X. J. (2004) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci049884m · Cited by 201 · see citing works
Computational prediction of formulation strategies for beyond-rule-of-5 compounds
Bergström, C. A. S., Charman, W. N., & Porter, C. J. H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.005 · Cited by 190 · see citing works
Formulation of amphotericin B as nanosuspension for oral administration
Kayser, O. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00686-5 · Cited by 187 · see citing works
Molecular inflation, attrition and the rule of five
Leeson, P. D. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.018 · Cited by 182 · see citing works
Saquinavir, an HIV Protease Inhibitor, Is Transported by P-Glycoprotein
Kim, A. E., Dintaman, J. M., Waddell, D. S., & Silverman, J. A. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37742-0 · Cited by 177 · see citing works
Predicting Effect of Food on Extent of Drug Absorption Based on Physicochemical Properties
Gu, C., Li, H., Levons, J. K., Lentz, K. A., Gandhi, R. B., Raghavan, K. S., & Smith, R. L. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9236-1 · Cited by 154 · see citing works
Soft Gelatin Capsules (Softgels)
Gullapalli, R. P. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22151 · Cited by 149 · see citing works
In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin
Hintzen, F., Perera, G., Hauptstein, S., Muller, C. R., Laffleur, F., & Bernkop‐Schnürch, A. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.05.047 · Cited by 147 · see citing works
Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line
Perloff, M. D., Moltke, L. L., Marchand, J. E., & Greenblatt, D. J. (2001) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.1133 · Cited by 135 · see citing works
The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review
Akhtar, N., Ahad, A., Khar, R. K., Jaggi, M., Aqil, M., Iqbal, Z., Ahmad, F. J., & Talegaonkar, S. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.561784 · Cited by 133 · see citing works
Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines.
Zgair, A., Wong, J. C. M., Lee, J. B., Mistry, J., Sivak, O., Wasan, K. M., Hennig, I. M., Barrett, D. A., Constantinescu, C. S., Fischer, P. M., et al. (2016) · Europe PMC (PubMed Central) · Cited by 130 · see citing works
Self-citation
Efficacy of Orally Delivered Cochleates Containing Amphotericin B in a Murine Model of Aspergillosis
Delmas, G., Park, S., Chen, Z. W., Tan, F., Kashiwazaki, R., Zarif, L., & Perlin, D. S. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.8.2704-2707.2002 · Cited by 110 · see citing works
Development of Amphotericin B-Loaded Cubosomes Through the SolEmuls Technology for Enhancing the Oral Bioavailability
Yang, Z., Tan, Y., Chen, M., Dian, L., Shan, Z., Peng, X., & Wu, C. (2012) · AAPS PharmSciTech · doi:10.1208/s12249-012-9876-2 · Cited by 99 · see citing works
Does Lipid Emulsion Reduce Amphotericin B Nephrotoxicity? A Systematic Review and Meta-analysis
Mistro, S., Maciel, I. D. M., de Menezes, R. G., Maia, Z. P. G., Schooley, R. T., & Badaró, R. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis290 · Cited by 92 · see citing works
Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation
Gershkovich, P., Wasan, E. K., Lin, M., Sivak, O., Leon, C. G., Clement, J. G., & Wasan, K. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp140 · Cited by 81 · see citing works
Self-citation
Inconsistent Labeling of Food Effect for Oral Agents across Therapeutic Areas: Differences between Oncology and Non-Oncology Products
Kang, S. P., & Ratain, M. J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0663 · Cited by 79 · see citing works
Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection
Xu, P., Yang, Z., Chen, M., Yang, M., Chen, J., & Fang, W. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s54967 · Cited by 79 · see citing works
Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia
Johansen, H. K., & Gøtzsche, P. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000969.pub2 · Cited by 77 · see citing works
Enhancing drug absorption using lipids: A case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections
Sachs‐Barrable, K., Lee, S. D., Wasan, E. K., Thornton, S. J., & Wasan, K. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.042 · Cited by 76 · see citing works
Self-citation
Amprenavir
Adkins, J. C., & Faulds, D. M. (1998) · Drugs · doi:10.2165/00003495-199855060-00015 · Cited by 74 · see citing works
A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model
Wasan, E. K., Gershkovich, P., Zhao, J., Zhu, X., Werbovetz, K. A., Tidwell, R. R., Clement, J. G., Thornton, S. J., & Wasan, K. M. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000913 · Cited by 63 · see citing works
Self-citation
A Review on Novel Therapeutic Strategies for the Enhancement of Solubility for Hydrophobic Drugs through Lipid and Surfactant Based Self Micro Emulsifying Drug Delivery System: A Novel Approach
Agrawal, S., Giri, T. K., Tripathi, D. K., Ajazuddin, M., & Alexander, A. (2012) · American Journal of Drug Discovery and Development · doi:10.3923/ajdd.2012.143.183 · Cited by 63 · see citing works
Application of Lipid-Based Formulations in Drug Discovery
Chen, X., Gudmundsson, O. S., & Hageman, M. J. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3006433 · Cited by 62 · see citing works
Drug permeability across a phospholipid vesicle-based barrier
Flaten, G. E., Luthman, K., Vasskog, T., & Brandl, M. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.04.001 · Cited by 59 · see citing works
Flushing Oral Oncology Drugs Down the Toilet
Ratain, M. J. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.1617 · Cited by 53 · see citing works
Effect of Polyoxyl 35 Castor Oil and Polysorbate 80 on the Intestinal Absorption of Digoxin in vitro
Cornaire, G., Woodley, J. F., Saivin, S., Legendre, J., Decourt, S., Cloarec, A., & Houin, G. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300252 · Cited by 53 · see citing works
Currently Marketed Oral Lipid-Based Dosage Forms: Drug Products and Excipients
Strickley, R. G. (2007) · CRC Press eBooks · doi:10.3109/9781420017267-4 · Cited by 52 · see citing works
Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach
Katneni, K., Charman, S. A., & Porter, C. J. H. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20779 · Cited by 49 · see citing works
Amphotericin B colloidal dispersion: an improved antifungal therapy
Guo, L. S. S. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00104-1 · Cited by 49 · see citing works
Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats
Risovic, V., Boyd, M. C., Choo, E., & Wasan, K. M. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3339-3342.2003 · Cited by 48 · see citing works
Self-citation
Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles
Sheu, M., Chen, Y., Su, C.-Y., Jhan, H.-J., & Ho, H.-O. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s95194 · Cited by 40 · see citing works
Effect of saquinavir/ritonavir on P-glycoprotein activity in healthy volunteers using digoxin as a probe
Schmitt, C., Kaeser, B., Riek, M., Bech, N., & Kreuzer, C. (2010) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp48192 · Cited by 38 · see citing works
In Vitro and In Vivo Evaluation of a Water-in-Oil Microemulsion System for Enhanced Peptide Intestinal Delivery
Liu, D., Kobayashi, T., Russo, S. M., Li, F., Plevy, S. E., Gambling, T. M., Carson, J. L., & Mumper, R. J. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9441-7 · Cited by 35 · see citing works
In vitro activity of amphotericin B cochleates against Leishmania chagasi
Sesana, A. M., Monti-Rocha, R., Vinhas, S. A., Morais, C. G., Dietze, R., & Lemos, E. M. (2011) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762011000200022 · Cited by 33 · see citing works
Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases
Rao, S., Tan, A., Thomas, N., & Prestidge, C. A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.013 · Cited by 33 · see citing works
Softgels: Consumer perceptions and market impact relative to other oral dosage forms
Jones, W. J., & Francis, J. J. (2000) · Advances in Therapy · doi:10.1007/bf02853160 · Cited by 28 · see citing works
Tropically stable novel oral lipid formulation of amphotericin B (iCo-010): biodistribution and toxicity in a mouse model
Sivak, O., Gershkovich, P., Lin, M., Wasan, E. K., Zhao, J., Owen, D., Clement, J. G., & Wasan, K. M. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-135 · Cited by 27 · see citing works
Self-citation
Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo
Guo, L., Erli, M., Zhao, H., Long, Y., Zheng, C., & Duan, M. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.029 · Cited by 24 · see citing works
Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice
Gershkovich, P., Wasan, E. K., Sivak, O., Li, R.-N., Zhu, X., Werbovetz, K. A., Tidwell, R. R., Clement, J. G., Thornton, S. J., & Wasan, K. M. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp465 · Cited by 23 · see citing works
Self-citation
Amphotericin B cochleates: a vehicle for oral delivery.
Perlin, D. S. (2004) · PubMed · Cited by 18 · see citing works
Synergistic enhancement of parasiticidal activity of amphotericin B using copaiba oil in nanoemulsified carrier for oral delivery: an approach for non‐toxic chemotherapy
Gupta, P. K., Jaiswal, A. K., Asthana, S., Venkatesh Teja, B., Shukla, P., Shukla, M., Sagar, N., Dube, A., Rath, S. K., & Mishra, P. R. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13149 · Cited by 18 · see citing works
Assessing the Antifungal Activity of a New Oral Lipid-Based Amphotericin B Formulation Following Administration to Rats Infected withAspergillus Fumigatus
Risovic, V., Rosland, M., Sivak, O., Wasan, K. M., & Bartlett, K. H. (2007) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040601077349 · Cited by 17 · see citing works
Self-citation
Reduced intrapatient variability of cyclosporine pharmacokinetics in renal transplant recipients switched from oral sandimmune to neoral
Mendez, R., Abboud, H. E., Burdick, J. F., Copley, B., Freeman, R. B., Batiuk, T. D., Cooney, G. F., & Barbeito, R. (1999) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)88276-4 · Cited by 17 · see citing works

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Moreno‐Alcántar, G., Picchetti, P., & Casini, A. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202218000 · Cited by 204 · see citing works
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Nyamba, I., Sombié, C. B., Yabré, M., Zimé-Diawara, H., Yaméogo, J. B. G., Ouédraogo, S., Lechanteur, A., Semdé, R., & Évrard, B. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114513 · Cited by 188 · see citing works
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Ditzinger, F., Price, D. J., Ilie, A.-R., Koehl, N. J., Janković, S., Τσακιρίδου, Γ., Aleandri, S., Kalantzi, L., Holm, R., Nair, A., et al. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12984 · Cited by 144 · see citing works
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Huang, Y., Yu, Q., Chen, Z., Wu, W., Zhu, Q., & Lü, Y. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.025 · Cited by 104 · see citing works
Trends in small molecule drug properties: A developability molecule assessment perspective
Agarwal, P., Huckle, J. E., Newman, J., & Reid, D. L. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103366 · Cited by 96 · see citing works
Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe
Yadav, P., Rastogi, V., & Verma, A. K. (2020) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00023-3 · Cited by 99 · see citing works
Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population
Salunke, S., O’Brien, F., Tan, D. C. T., Harris, D., Math, M.-C., Ariën, T., Klein, S., & Timpe, C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114507 · Cited by 93 · see citing works
Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells
Garner, L. C., Klenerman, P., & Provine, N. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01478 · Cited by 88 · see citing works
Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers
Izgelov, D., Davidson, E. M., Barasch, D., Regev, A., Domb, A. J., & Hoffman, A. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.06.021 · Cited by 88 · see citing works
Physical formulation approaches for improving aqueous solubility and bioavailability of ellagic acid: A review
Nyamba, I., Lechanteur, A., Semdé, R., & Évrard, B. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.11.004 · Cited by 88 · see citing works
Vitamin E TPGS-Based Nanomedicine, Nanotheranostics, and Targeted Drug Delivery: Past, Present, and Future
Mehata, A. K., Setia, A., Vikas, Malik, A., Hassani, R., Dailah, H., Alhazmi, H., Albarraq, A. A., Mohan, S., & Muthu, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030722 · Cited by 73 · see citing works
Lipid-Based Oral Formulation Strategies for Lipophilic Drugs
Patel, V., Lalani, R., Bardoliwala, D., Ghosh, S., & Misra, A. R. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1188-8 · Cited by 80 · see citing works
Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five
Stegemann, S., Moreton, C., Svanbäck, S., Box, K. J., Motte, G., & Paudel, A. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103344 · Cited by 81 · see citing works
Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes
ElFar, O. A., Billa, N., Lim, H. R., Chew, K. W., Cheah, W. Y., Munawaroh, H. S. H., Deepanraj, B., & Show, P. L. (2022) · Bioengineered · doi:10.1080/21655979.2022.2100863 · Cited by 84 · see citing works
Self-microemulsifying drug-delivery system: ongoing challenges and future ahead
Rajpoot, K., Tekade, M., Pandey, V., Sreeharsha, N., Youngren-Ortiz, S. R., & Tekade, R. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814487-9.00009-0 · Cited by 76 · see citing works
Lipid–oligonucleotide conjugates for bioapplications
Li, X., Feng, K., Li, L., Yang, L., Pan, X., Yazd, H. S., Cui, C., Li, J., Moroz, L. L., Sun, Y., et al. (2020) · National Science Review · doi:10.1093/nsr/nwaa161 · Cited by 74 · see citing works
Gout therapeutics and drug delivery
Peng, X., Li, X., Xie, B., Lai, Y., Sosnik, A., Boucetta, H., Chen, Z., & He, W. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.011 · Cited by 75 · see citing works
Lipid based formulations as supersaturating oral delivery systems: From current to future industrial applications
Holm, R., Kuentz, M., Ilie, A.-R., & Griffin, B. T. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106556 · Cited by 69 · see citing works
Lipid nanoparticles for enhancing oral bioavailability
Gangavarapu, A., Tapia-Lopez, L. V., Sarkar, B., Pena‐Zacarias, J., Badruddoza, A. Z. M., & Nurunnabi, M. (2024) · Nanoscale · doi:10.1039/d4nr01487a · Cited by 64 · see citing works
All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance
Hatton, G. B., Madla, C. M., Rabbie, S. C., & Basit, A. W. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.054 · Cited by 64 · see citing works
Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming
Fang, J., Hsueh, Y., Soto, J., Sun, W., Wang, J., Gu, Z., Khademhosseini, A., & Li, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b04837 · Cited by 60 · see citing works
Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing
Tan, D. K., Davis, D. A., Miller, D. A., Williams, R. O., & Nokhodchi, A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01854-2 · Cited by 60 · see citing works
Bridging the gaps between academic research and industrial product developments of lipid-based formulations
Holm, R. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.009 · Cited by 59 · see citing works
Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption
Al-Ali, A. A. A., Nielsen, R. B., Steffansen, B., Holm, R., & Nielsen, C. U. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.05.033 · Cited by 58 · see citing works
Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®: a Review
Ellenberger, D., Miller, D. A., & Williams, R. O. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1007-2 · Cited by 54 · see citing works
Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies
Silmore, L. H., Willmer, A. R., Capparelli, E. V., & Rosania, G. R. (2021) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2512 · Cited by 52 · see citing works
Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks
Bennett-Lenane, H., Griffin, B. T., & O’Shea, J. P. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106018 · Cited by 51 · see citing works
Nanostructured lipid carrier potentiated oral delivery of raloxifene for breast cancer treatment
Soni, N. K., Sonali, L., Singh, A., Mangla, B., Neupane, Y. R., & Kohli, K. (2020) · Nanotechnology · doi:10.1088/1361-6528/abaf81 · Cited by 50 · see citing works
Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications
Thakur, S., Singh, A., Sharma, R., Aurora, R., & Jain, S. K. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666201008143238 · Cited by 47 · see citing works
Interactions between antiretroviral therapy and complementary and alternative medicine: a narrative review
Bordes, C., Leguelinel, G., Lavigne, J.-P., Mauboussin, J. M., Laureillard, D., Faure, H., Rouanet, I., Sotto, A., & Loubet, P. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.04.019 · Cited by 47 · see citing works
Nano- and Microencapsulation - Techniques and Applications
Abu-Thabit, N. Y. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.88590 · Cited by 46 · see citing works
Cutting-edge advances in therapy for the posterior segment of the eye: Solid lipid nanoparticles and nanostructured lipid carriers
de Oliveira, I. F., Barbosa, E. J., Peters, M. C. C., Henostroza, M. A. B., Yukuyama, M. N., Neto, E. D. S., Löbenberg, R., & Bou‐Chacra, N. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119831 · Cited by 45 · see citing works
Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment
Rocha, S., Lucas, M., Ribeiro, D., Corvo, M. L., Fernandes, E. G. R., & Freitas, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105604 · Cited by 45 · see citing works
RNA Nanotechnology to Solubilize Hydrophobic Antitumor Drug for Targeted Delivery
Piao, X., Yin, H., Guo, S., Wang, H., & Guo, P. (2019) · Advanced Science · doi:10.1002/advs.201900951 · Cited by 44 · see citing works
Treatment challenges and delivery systems in immunomodulation and probiotic therapies for periodontitis
Zidar, A., Kristl, J., Kocbek, P., & Zupančič, Š. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1908260 · Cited by 44 · see citing works
Development of Solid Dispersion by Hot Melt Extrusion Using Mixtures of Polyoxylglycerides With Polymers as Carriers for Increasing Dissolution Rate of a Poorly Soluble Drug Model
Vasoya, J. M., Desai, H. H., Gumaste, S. G., Tillotson, J., Kelemen, D. W., Dalrymple, D. M., & Serajuddin, A. T. M. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.09.019 · Cited by 43 · see citing works
Supersaturated LFCS type III self-emulsifying delivery systems of sorafenib tosylate with improved biopharmaceutical performance: QbD-enabled development and evaluation
Sharma, T., Jain, A., Kaur, R., Saini, S., Katare, O. P., & Singh, B. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00772-x · Cited by 42 · see citing works
Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives
Abla, K. K., & Mehanna, M. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.018 · Cited by 41 · see citing works
Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)
Baghel, P., Roy, A. K., Verma, S., Satapathy, T., & Bahadur, S. (2020) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00042-0 · Cited by 41 · see citing works
PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations
Kambayashi, A., Kiyota, T., Fujiwara, M., & Dressman, J. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.05.013 · Cited by 40 · see citing works
Micelles of progesterone for topical eye administration: interspecies and intertissues differences in Ex vivo ocular permeability
Alambiaga-Caravaca, A. M., Calatayud-Pascual, M. A., Rodilla, V., Concheiro, A., López-Castellano, A., & Alvarez-Lorenzo, C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080702 · Cited by 38 · see citing works
A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?
Bennett-Lenane, H., O’Shea, J. P., O’Driscoll, C. M., & Griffin, B. T. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.08.008 · Cited by 37 · see citing works
Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques
Ngwuluka, N. C., Abu-Thabit, N. Y., Uwaezuoke, O. J., Erebor, J. O., Ilomuanya, M. O., Mohamed, R. R., Soliman, S. M. A., Elella, M. H. A., & Ebrahim, N. A. A. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.94856 · Cited by 37 · see citing works
Surfactant-Enabled Nanocarriers in Breast Cancer Therapy: Targeted Delivery and Multidrug Resistance Reversal
Jadhav, A., & Nagaraj, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060779 · Cited by 35 · see citing works
Benefits of hypericin transport and delivery by low- and high-density lipoproteins to cancer cells: From in vitro to ex ovo
Lenkavská, L., Blaščáková, Ľ., Jurašeková, Z., Máčajová, M., Bilčı́k, B., Čavarga, I., Miškovský, P., & Huntošová, V. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.12.013 · Cited by 34 · see citing works
A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids
Dombach, J. L., Quintana, J. L. J., Nagy, T. A., Wan, C., Crooks, A. L., Yu, H., Su, C., Yu, E. W., Shen, J., & Detweiler, C. S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1009119 · Cited by 34 · see citing works
Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption
Ilie, A.-R., Griffin, B. T., Brandl, M., Bauer-Brandl, A., Jacobsen, A.-C., Vertzoni, M., Kuentz, M., Kolakovic, R., & Holm, R. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105452 · Cited by 33 · see citing works
“excipients plus a co-solvent, it would be preferable to consider less complex LBDDS that can be rapidly screened in an industrial drug development setting (Holm, 2019; Savla et al., 2017; Müllertz et al., 2010).”
Background
Micronization of a poorly water-soluble drug, fenofibrate, via supercritical-fluid-assisted spray-drying
Kim, J. S., Park, H., Kang, K., Ha, E., Kim, M., & Hwang, S. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00565-z · Cited by 33 · see citing works
Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans
Okonogi, S., Phumat, P., Khongkhunthian, S., Chaijareenont, P., Rades, T., & Müllertz, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020167 · Cited by 32 · see citing works
PEG vs. zwitterions: How these surface decorations determine cellular uptake of lipid-based nanocarriers
Stengel, D., Demirel, B. H., Knoll, P., Truszkowska, M., Laffleur, F., & Bernkop‐Schnürch, A. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.05.079 · Cited by 32 · see citing works
Polyphosphate coatings: A promising strategy to overcome the polycation dilemma
Le, N. N., Steinbring, C., Le‐Vinh, B., Jalil, A., Matuszczak, B., & Bernkop‐Schnürch, A. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.12.019 · Cited by 32 · see citing works
Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study
Arbeiter, D., Reske, T., Teske, M., Bajer, D., Senz, V., Schmitz, K., Grabow, N., & Oschatz, S. (2021) · Polymers · doi:10.3390/polym13020292 · Cited by 31 · see citing works
Supersaturated lipid-based drug delivery systems – exploring impact of lipid composition type and drug properties on supersaturability and physical stability
Ilie, A.-R., Griffin, B. T., Kolakovic, R., Vertzoni, M., Kuentz, M., & Holm, R. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1721526 · Cited by 30 · see citing works
Alginate-coating of artemisinin-loaded cochleates results in better control over gastro-intestinal release for effective oral delivery
Shuddhodana, S., & Judeh, Z. M. A. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.04.020 · Cited by 29 · see citing works
Nanoparticle technologies: Recent state of the art and emerging opportunities
Parupudi, A., Mulagapati, S. H. R., & Subramony, J. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820757-4.00009-0 · Cited by 31 · see citing works
Fatty acids as essential adjuvants to treat various ailments and their role in drug delivery: A review
Katdare, A., Thakkar, S., Dhepale, S., Khunt, D., & Misra, M. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.008 · Cited by 29 · see citing works
Drug solubility in fatty acids as a formulation design approach for lipid-based formulations: a technical note
Lee, Y.-C., Dalton, C. R., Regler, B. P., & Harris, D. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1483395 · Cited by 28 · see citing works
Evaluation of Cytotoxicity of Self-Emulsifying Formulations Containing Long-Chain Lipids Using Caco-2 Cell Model: Superior Safety Profile Compared to Medium-Chain Lipids
Desai, H. H., Bu, P., Shah, A. V., Cheng, X., & Serajuddin, A. T. M. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.01.031 · Cited by 28 · see citing works
Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations
Hedge, O. J., & Bergström, C. A. S. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02833-9 · Cited by 28 · see citing works
Engineered Aptamer‐Organic Amphiphile Self‐Assemblies for Biomedical Applications: Progress and Challenges
Xiong, H., Liu, L., Wang, Y., Jiang, H., & Wang, X. (2021) · Small · doi:10.1002/smll.202104341 · Cited by 27 · see citing works
The structural fate of lipid nanoparticles in the extracellular matrix
Bandara, S. R., Molley, T. G., Kim, H., Bharath, P., Kilian, K. A., & Leal, C. (2019) · Materials Horizons · doi:10.1039/c9mh00835g · Cited by 27 · see citing works
Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) Lipid with Various Metal Cations in Nanocochleate Preformulation: Application for Andrographolide Oral Delivery in Cancer Therapy
Ahiwale, R. J., Bothiraja, C., & Pawar, A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01801-1 · Cited by 26 · see citing works
Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach
Viglianisi, G., Santonocito, S., Lupi, S. M., Amato, M., Spagnuolo, G., Pesce, P., & Isola, G. (2023) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223231191043 · Cited by 26 · see citing works
Early evaluation of opportunities in oral delivery of PROTACs to overcome their molecular challenges
Yang, W., Saboo, S., Zhou, L., Askin, S., & Bak, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103865 · Cited by 24 · see citing works
Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling–Case Example Ritonavir
Fiolka, T., Αbeele, J. V. D., Augustijns, P., Arora, S., & Dressman, J. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.04.023 · Cited by 24 · see citing works
Solid Lipid Nanoparticles for Efficient Oral Delivery of Tyrosine Kinase Inhibitors: A Nano Targeted Cancer Drug Delivery
Satapathy, S. K., & Patro, C. S. (2021) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2022.041 · Cited by 27 · see citing works
Aqueous solubility of kinase inhibitors: I the effect of hydrophilic polymers on their γ-cyclodextrin solubilization
Praphanwittaya, P., Saokham, P., Jansook, P., & Loftsson, Þ. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101462 · Cited by 24 · see citing works
Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: part 2. development of oral dosage formulations
Murakami, T., Bodor, E. T., & Bodor, N. S. (2023) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2023.2203858 · Cited by 23 · see citing works
A recent update on therapeutic potential of vesicular system against fungal keratitis
Sanap, S. N., Kedar, A. S., Bisen, A. C., Agrawal, S., & Bhatta, R. S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103721 · Cited by 23 · see citing works
Molecular Dynamics Simulation Studies of Bile, Bile Salts, Lipid-Based Drug Formulations, and mRNA–Lipid Nanoparticles: A Review
Guruge, A. G., Warren, D. B., Pouton, C. W., & Chalmers, D. K. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00049 · Cited by 24 · see citing works
Lubrication and Dynamically Controlled Drug Release Properties of Tween 85/Tween 80/H2O Lamellar Liquid Crystals
Lu, X., Fan, L., Song, C., Xu, Z., Hu, Y., & Guo, R. H. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c00659 · Cited by 22 · see citing works
Rationale utilization of phospholipid excipients: a distinctive tool for progressing state of the art in research of emerging drug carriers
Koilpillai, J., & Narayanasamy, D. (2022) · Journal of Liposome Research · doi:10.1080/08982104.2022.2069809 · Cited by 22 · see citing works
Biomimetic polysaccharide-cloaked lipidic nanovesicles/microassemblies for improving the enzymatic activity and prolonging the action time for hyperuricemia treatment
Yang, L., Zhang, Y., Xie, J., Zhong, C., He, D., Wang, T., Li, K., Li, Y., Shi, D., Abagyan, R. A., et al. (2020) · Nanoscale · doi:10.1039/d0nr02651d · Cited by 22 · see citing works
A dataset of formulation compositions for self-emulsifying drug delivery systems
Zaslavsky, J., & Allen, C. J. (2023) · Scientific Data · doi:10.1038/s41597-023-02812-w · Cited by 22 · see citing works
Formulation and Evaluation of SNEDDS Loaded with Original Lipophenol for the Oral Route to Prevent Dry AMD and Stragardt’s Disease
Vincent, M., Simon, L., Brabet, P., Legrand, P., Dorandeu, C., Lai‐Kee‐Him, J., Durand, T., Crauste, C., & Bégu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051029 · Cited by 21 · see citing works
Effect of excipients on oral absorption process according to the different gastrointestinal segments
Ruiz-Picazo, A., Lozoya-Agulló, I., González‐Álvarez, I., Bermejo, M., & González‐Álvarez, M. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1813108 · Cited by 22 · see citing works
Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model
Falavigna, M., Klitgaard, M., Berthelsen, R., Müllertz, A., & Flaten, G. E. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.08.026 · Cited by 21 · see citing works
Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review
Swarnakar, N. K., Venkatesan, N., & Betageri, G. V. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1239-1 · Cited by 20 · see citing works
Factors and dosage formulations affecting the solubility and bioavailability of P-glycoprotein substrate drugs
Murakami, T., Bodor, E. T., & Bodor, N. S. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1902986 · Cited by 20 · see citing works
Interplay of lipid and surfactant: Impact on nanoparticle structure
Pink, D. L., Loruthai, O., Ziolek, R. M., Terry, A. E., Barlow, D. J., Lawrence, M. J., & Lorenz, C. D. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.03.136 · Cited by 20 · see citing works
Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule
Vanti, G., Muti, L., D’Ambrosio, M., Grifoni, L., Bergonzi, M. C., Luceri, C., & Bilia, A. R. (2021) · Molecules · doi:10.3390/molecules26247657 · Cited by 20 · see citing works
Critical aspects involved in lipid dispersion and digestion: Emphasis on in vitro models and factors influencing lipolysis of oral lipid based formulations
Sirvi, A., Debaje, S., Guleria, K., & Sangamwar, A. T. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.103028 · Cited by 20 · see citing works
Filament-based 3D-printing of placebo dosage forms using brittle lipid-based excipients
Abdelhamid, M., Koutsamanis, I., Corzo, C., Maisriemler, M., Ocampo, A. B., Slama, E., Alva, C., Lochmann, D., Reyer, S., Freichel, T., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122013 · Cited by 19 · see citing works
Solid Lipid Nanoparticles: An Innovative Drug Delivery System for Enhanced Bioavailability and Targeted Therapy
Aggarwal, K., Joshi, S., Jindal, P., Patel, P., & Kurmi, B. D. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03185-6 · Cited by 18 · see citing works
Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids
Almasri, R., Joyce, P., Schultz, H. B., Thomas, N., Bremmell, K. E., & Prestidge, C. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070687 · Cited by 18 · see citing works
Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum
Jaromin, A., Parapini, S., Basilico, N., Zaremba-Czogalla, M., Lewińska, A., Zagórska, A., Walczak, M., Tyliszczak, B., Grzeszczak, A., Łukaszewicz, M., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.10.004 · Cited by 18 · see citing works
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Stanczyk, F. Z., Matharu, H., & Winer, S. A. (2021) · Climacteric · doi:10.1080/13697137.2020.1862079 · Cited by 18 · see citing works
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Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release
Lee, D., Song, S., Kim, S., Lee, M., Kim, E., Yoon, S., Kim, H., Son, S., Jung, H. S., Huh, Y. S., et al. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.3c00528 · Cited by 17 · see citing works
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Izgelov, D., Regev, A., Domb, A. J., & Hoffman, A. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00141 · Cited by 18 · see citing works
Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs
Falavigna, M., Brurok, S., Klitgaard, M., & Flaten, G. E. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120258 · Cited by 17 · see citing works
Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment
Zhang, H., Yao, J., Jiang, Q., Shi, Y.-R., Ge, W., & Xu, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070935 · Cited by 16 · see citing works
Mechanisms of drug solubilization by polar lipids in biorelevant media
Katev, V., Vinarov, Z., & Tcholakova, S. S. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105733 · Cited by 17 · see citing works
Lipid-based formulations of microemulsion-loaded oleogels for the oral delivery of carvedilol
Hamed, R., Seder, B. Y., Bardaweel, S. K., & Qawass, H. (2021) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2021.1964987 · Cited by 16 · see citing works
Low-surfactant microemulsion, a smart strategy intended for curcumin oral delivery
Dourado, D., de Oliveira, M. C., de Araújo, G. R. S., Amaral-Machado, L., Porto, D. L., Aragão, C. F. S., Alencar, É. D. N., & do Egito, E. S. T. (2022) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2022.129720 · Cited by 15 · see citing works
Conjugates of amphotericin B to resolve challenges associated with its delivery
Jain, V. K., Jain, K., & Popli, H. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2308073 · Cited by 15 · see citing works

Advancement in Lipid-Based Drug Delivery System: A Comprehensive Review
ShekharV, K., Vilas, V. S., & Ushir, Y. V. (2024) · International Journal of Biological and Environmental Investigations · doi:10.33745/ijzi.2024.v10i01.088
Improvement & innovation trends in lipid based drug delivery system
Kand, M. B. L., Patra, M. B. B., & Mishra, M. D. K. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.15814060
Recent advances in lipid based formulations
Usha, A. L., Panda, J., Chandralekha, M., Parimala, P., Saranya, B. A., Meghana, J., & Sreeram, K. K. (2026) · International Journal of Pharmacy and Pharmaceutical Science · doi:10.33545/26647222.2026.v8.i1a.289
A Comprehensive Overview of Lipid-Based Drug Delivery Approach
Abourobe, N. M., Hassan, T. H., Gad, S., & Mostafa, Y. (2022) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2022.231970 · Cited by 2 · see citing works
Insights of Lipid-Based Drug Delivery Systems with an Emphasis on Quality by Design: Pharmaceutical Science-Pharmaceutics
Battula, V., Chinthaginjala, H., Telkar, M. B., Singh, U. N., Bobbarjang, N., & Bhargav, E. (2023) · International Journal of Life Science and Pharma Research

Authors: Savla, R., Browne, J., Plassat, V., Wasan, K. M., & Wasan, E. K.
Affiliations: Catalent (United States) (US)
Cerenis Therapeutics (France) (FR)
University of Saskatchewan (CA)
Corresponding author: Savla, Ronak
ORCID: Savla, Ronak
Plassat, Vincent
Wasan, Kishor M.
Wasan, Ellen K.
Venue: Drug Development and Industrial Pharmacy
Publisher: Informa UK Limited
Published: 2017-07-06
Volume: 43
Issue: 11
Pages: 1743-1758
ISSN: 0363-9045 (ISSN-L)
1520-5762
DOI: 10.1080/03639045.2017.1342654
OpenAlex: W2732877934
Cited by: 225
References: 75
Citations by year: 2026: 12 · 2025: 24 · 2024: 23 · 2023: 23 · 2022: 27 · 2021: 39 · 2020: 42 · 2019: 21 · 2018: 14
FWCI: 10.88
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Drug Development and Industrial Pharmacy (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Figshare (cc-by)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords: lipid-based drug delivery, bioavailability enhancement, FDA-approved drugs, physicochemical properties, molecular properties
MeSH terms: Biological Availability, Chemistry, Pharmaceutical, Humans, Lipids, United States, Drug Delivery Systems, Drug Approval

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