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Cited by 25Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Prolonged skin retention of clobetasol propionate by bio-based microemulsions: a potential tool for scalp psoriasis treatment

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Langasco, Rita, Tanrıverdi, Sakine Tuncay, Özer, Özgen, Roldo, Marta, Cossu, Massimo, Rassu, Giovanna, Giunchedi, Paolo, Gavini, Elisabetta·2018·Drug Development and Industrial Pharmacy
DOI 10.1080/03639045.2017.1395458
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Abstract

Novel effective and cosmetically acceptable formulations are needed for the treatment of scalp psoriasis, due to the poor efficacy of the current products. The challenge in developing safe, efficient, and convenient delivery systems for this drug was addressed in the present work by formulating clobetasol propionate-loaded W/O microemulsions (MEs). Pseudo-ternary phase diagrams were constructed by using a combination of biocompatible and biodegradable excipients. Characterization studies demonstrated that selected MEs had suitable technological features such as being Newtonian fluids, possessing low viscosity, and high thermodynamic stability. Photomicrographs showed a significant alteration of the skin structure after treatment with MEs, and a preferential concentration of these in the stratum corneum and epidermis. These data, together with ex vivo permeation results, suggested an enhanced topical targeted effect due to an increased drug retention efficacy in the upper skin layers, as desired. Moreover, the bio-based excipients selected could contribute to the healing of the psoriatic scalp. In this way, the improvement of clobetasol efficacy is combined with the useful properties of the microemulsion components and with environmental safety.

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Crossref · 10.1080/03639045.2017.1395458

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Research works printed but not linked: 4

  1. Damasceno BPGL, 2011, Revista De Ciencias Farmaceuticas Basica e Aplicada, 32, 9
  2. Fiedler HP, 2002, Encyclopedia of excipients for pharmaceuticals, cosmetics and related areas
  3. Shah RR, 2009, Res J Pharm Tech, 2, 353
  4. Salimi A, 2013, Iran J Basic Med Sci, 16, 865

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Metadata

Authors
Langasco, R., Tanrıverdi, S. T., Özer, Ö., Roldo, M., Cossu, M., Rassu, G., Giunchedi, P., & Gavini, E.
Affiliations
  • University of Sassari (IT)
  • Ege University (TR)
  • University of Portsmouth (GB)
Corresponding author
Gavini, Elisabetta
ORCID
Venue
Drug Development and Industrial Pharmacy
Publisher
Informa UK Limited
Published
2017-11-08
Volume
44
Issue
3
Pages
398-406
ISSN
  • 0363-9045 (ISSN-L)
  • 1520-5762
DOI
10.1080/03639045.2017.1395458
OpenAlex
W2766740795
Cited by
25
References
62
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Drug Development and Industrial Pharmacy (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • UnissResearch (Università degli Studi di Sassari) (submittedVersion)
  • Figshare (cc-by)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Keywords
clobetasol propionate, scalp psoriasis, water-in-oil microemulsions, biodegradable excipients, topical drug delivery, skin retention, stratum corneum, ex vivo skin permeation, pseudo-ternary phase diagram, topical corticosteroids
MeSH terms
Administration, Cutaneous, Animals, Biocompatible Materials, Chemistry, Pharmaceutical, Clobetasol, Emulsions, Epidermis, Excipients, Particle Size, Permeability, Psoriasis, Scalp, Skin, Skin Absorption, Swine

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