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Cited by 268

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Selective laser sintering 3D printing – an overview of the technology and pharmaceutical applications

Charoo, Naseem A., Barakh Ali, Sogra F., Mohamed, Eman M., Kuttolamadom, Mathew A., Ozkan, Tanil, Khan, Mansoor A., Rahman, Ziyaur·2020·Drug Development and Industrial Pharmacy

Abstract

Food and Drug Administration (FDA) has approved a drug product (Spritam®) and many medical devices manufactured by three-dimensional printing (3DP) processes for human use. There is immense potential to print personalized medicines using 3DP. Many 3DP methods have been reported in the literature for pharmaceutical applications. However, selective laser sintering (SLS) printing has remained least explored for pharmaceutical applications. There are many advantages and challenges in adopting a SLS method for fabrication of personalized medicines. Solvent-free nature, availability of FDA approved thermoplastic polymer/excipients (currently used in hot melt-extrusion process), minimal/no post-processing step, etc. are some of the advantages of the SLS printing process. Major challenges of the technology are requirement of at least one thermoplastic component in the formulation and thermal stability of drug and excipients. This review provides an overview of the SLS printing method, excipient requirements, process monitoring, quality defects, regulatory aspects, and potential pharmaceutical applications.

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Metadata

Authors
Charoo, N. A., Barakh Ali, S. F., Mohamed, E. M., Kuttolamadom, M. A., Ozkan, T., Khan, M. A., & Rahman, Z.
Venue
Drug Development and Industrial Pharmacy
Published
2020-05-13
Volume
46
Issue
6
Pages
869-877
ISSN
  • 0363-9045 (ISSN-L)
  • 1520-5762
OpenAlex
W3023184743
Cited by
268
References
50
FWCI
10.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Selective laser sintering 3D printing – an overview of the technology and pharmaceutical applications. https://app.cochat.ai/papers/10.1080/03639045.2020.1764027
The paper
Charoo, N. A., Barakh Ali, S. F., Mohamed, E. M., Kuttolamadom, M. A., Ozkan, T., Khan, M. A., & Rahman, Z. (2020). Selective laser sintering 3D printing – an overview of the technology and pharmaceutical applications. Drug Development and Industrial Pharmacy. https://doi.org/10.1080/03639045.2020.1764027

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.