The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 Adipocytes
Abstract
OBJECTIVES: These studies investigated the ability of a hydroxychalcone from cinnamon to function as an insulin mimetic in 3T3-LI adipocytes. METHODS: Comparative experiments were performed with the cinnamon methylhydroxychalcone polymer and insulin with regard to glucose uptake, glycogen synthesis. phosphatidylinositol-3-kinase dependency, glycogen synthase activation and glycogen synthase kinase-3beta activity. The phosphorylation state of the insulin receptor was also investigated. RESULTS: MHCP treatment stimulated glucose uptake and glycogen synthesis to a similar level as insulin. Glycogen synthesis was inhibited by both wortmannin and LY294002, inhibitors directed against the PI-3-kinase. In addition, MHCP treatment activated glycogen synthase and inhibited glycogen synthase kinase-3beta activities, known effects of insulin treatment. Analysis of the insulin receptor demonstrated that the receptor was phosphorylated upon exposure to the MHCP. This supports that the insulin cascade was triggered by MHCP. Along with comparing MHCP to insulin, experiments were done with MHCP and insulin combined. The responses observed using the dual treatment were greater than additive, indicating synergism between the two compounds. CONCLUSION: Together, these results demonstrate that the MHCP is an effective mimetic of insulin. MHCP may be useful in the treatment of insulin resistance and in the study of the pathways leading to glucose utilization in cells.
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“Both in vitro and in vivo animal studies have shown insulin-enhancing or insulin-like effects after cinnamon administration [365,366,367].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [366]
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Metadata
- Authors
- Jarvill-Taylor, K. J., Anderson, R. A., & Graves, D. J.
- Affiliations
- Iowa State University (US)
- United States Department of Agriculture (US)
- Corresponding author
- Graves, Donald J.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2001-08
- Volume
- 20
- Issue
- 4
- Pages
- 327-336
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2078460365
- Cited by
- 324
- References
- 28
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 16 · 2021: 15 · 2020: 13 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 22 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 21
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Diabetes Action Research and Education Foundation
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- hydroxychalcones, cinnamon, insulin mimetics, insulin resistance, 3T3-L1 adipocytes, glucose uptake, glycogen synthesis, glycogen synthase, glycogen synthase kinase-3β, phosphatidylinositol 3-kinase, insulin receptor phosphorylation
- MeSH terms
- Wortmannin, Phosphoinositide-3 Kinase Inhibitors, Androstadienes, Animals, Chromones, Cinnamomum zeylanicum, Enzyme Activation, Enzyme Inhibitors, Glucose, Glycogen, Glycogen Synthase, Insulin, Morpholines, Phosphorylation, Polymers, Receptor, Insulin, 3T3 Cells, Adipocytes, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Glycogen Synthase Kinases, Glycogen Synthase Kinase 3, Mice
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