Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity
Abstract
The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence that dietary factors are involved in its regulation and prevention. We have shown that extracts from cinnamon enhance the activity of insulin. The objective of this study was to isolate and characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as antioxidants, potentiate insulin action, and may be beneficial in the control of glucose intolerance and diabetes.
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A water-soluble type-A polyphenol polymer isolated from cinnamon has shown insulin-like and antioxidant activity in vitro.
“A water-soluble polyphenol typ-A polymer from cinnamon has been isolated and shown in vitro to have insulin-like activity as well as an antioxidant effect (2).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [2]
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- Authors
- Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Anderson, Richard A.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-12-03
- Volume
- 52
- Issue
- 1
- Pages
- 65-70
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2086795949
- Cited by
- 561
- References
- 26
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 19 · 2023: 27 · 2022: 16 · 2021: 38 · 2020: 37 · 2019: 25 · 2018: 26 · 2017: 30 · 2016: 21 · 2015: 29 · 2014: 37 · 2013: 28 · 2012: 33
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Santa Barbara
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- cinnamon, polyphenols, procyanidins, insulin-like activity, insulin sensitization, glucose metabolism, antioxidant activity, type 2 diabetes, impaired glucose tolerance, catechins, epicatechin, oligomers
- MeSH terms
- Antioxidants, Cinnamomum zeylanicum, Diabetes Mellitus, Flavonoids, Insulin, Magnetic Resonance Spectroscopy, Phenols, Mass Spectrometry, Glucose Intolerance, Polyphenols
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