Cited by 561Natural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesMedicinal Plant Research

Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity

Anderson, Richard A., Broadhurst, C. Leigh, Polansky, Marilyn M., Schmidt, Walter F., Khan, Alam, Flanagan, Vincent P., Schoene, Norberta W., Graves, Donald J.·2004·Journal of Agricultural and Food Chemistry

Abstract

The causes and control of type 2 diabetes mellitus are not clear, but there is strong evidence that dietary factors are involved in its regulation and prevention. We have shown that extracts from cinnamon enhance the activity of insulin. The objective of this study was to isolate and characterize insulin-enhancing complexes from cinnamon that may be involved in the alleviation or possible prevention and control of glucose intolerance and diabetes. Water-soluble polyphenol polymers from cinnamon that increase insulin-dependent in vitro glucose metabolism roughly 20-fold and display antioxidant activity were isolated and characterized by nuclear magnetic resonance and mass spectroscopy. The polymers were composed of monomeric units with a molecular mass of 288. Two trimers with a molecular mass of 864 and a tetramer with a mass of 1152 were isolated. Their protonated molecular masses indicated that they are A type doubly linked procyanidin oligomers of the catechins and/or epicatechins. These polyphenolic polymers found in cinnamon may function as antioxidants, potentiate insulin action, and may be beneficial in the control of glucose intolerance and diabetes.

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Crossref · 10.1021/jf034916b

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Authors
Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J.
Affiliations
Agricultural Research Service (US)
Corresponding author
Anderson, Richard A.
Venue
Journal of Agricultural and Food Chemistry
Published
2003-12-03
Volume
52
Issue
1
Pages
65-70
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2086795949
Cited by
561
References
26
Citations by year
2026: 10 · 2025: 14 · 2024: 19 · 2023: 27 · 2022: 16 · 2021: 38 · 2020: 37 · 2019: 25 · 2018: 26 · 2017: 30 · 2016: 21 · 2015: 29 · 2014: 37 · 2013: 28 · 2012: 33
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of California, Santa Barbara
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
cinnamon, polyphenols, procyanidins, insulin-like activity, insulin sensitization, glucose metabolism, antioxidant activity, type 2 diabetes, impaired glucose tolerance, catechins, epicatechin, oligomers
MeSH terms
Antioxidants, Cinnamomum zeylanicum, Diabetes Mellitus, Flavonoids, Insulin, Magnetic Resonance Spectroscopy, Phenols, Mass Spectrometry, Glucose Intolerance, Polyphenols

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