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Cited by 29Sports Performance and TrainingMuscle metabolism and nutritionExercise and Physiological Responses

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Oral Adenosine-5′-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout

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Purpura, Martin, Rathmacher, John A., Sharp, Matthew H., Lowery, Ryan P., Shields, Kevin A., Partl, Jeremy M., Wilson, Jacob M., Jäger, Ralf·2017·Journal of the American College of Nutrition
DOI 10.1080/07315724.2016.1246989
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Abstract

OBJECTIVE: Oral adenosine-5'-triphosphate (ATP) administration has failed to increase plasma ATP levels; however, chronic supplementation with ATP has shown to increase power, strength, lean body mass, and blood flow in trained athletes. The purpose of this study was to investigate the effects of ATP supplementation on postexercise ATP levels and on muscle activation and excitability and power following a repeated sprint bout. METHODS: In a double-blind, placebo-controlled, randomized design, 42 healthy male individuals were given either 400 mg of ATP as disodium salt or placebo for 2 weeks prior to an exercise bout. During the exercise bout, muscle activation and excitability (ME, ratio of power output to muscle activation) and Wingate test peak power were measured during all sprints. ATP and metabolites were measured at baseline, after supplementation, and immediately following exercise. RESULTS: Oral ATP supplementation prevented a drop in ATP, adenosine-5'-diphosphate (ADP), and adenosine-5'-monophosphate (AMP) levels postexercise (p < 0.05). No group by time interaction was observed for muscle activation. Following the supplementation period, muscle excitability significantly decreased in later bouts 8, 9, and 10 in the placebo group (-30.5, -28.3, and -27.9%, respectively; p < 0.02), whereas ATP supplementation prevented the decline in later bouts. ATP significantly increased Wingate peak power in later bouts compared to baseline (bout 8: +18.3%, bout 10: +16.3%). CONCLUSIONS: Oral ATP administration prevents exercise-induced declines in ATP and its metabolite and enhances peak power and muscular excitability, which may be beneficial for sports requiring repeated high-intensity sprinting bouts.

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  • Chronic supplementation with ATP increases the capacity to synthesize ATP within erythrocytes without increasing resting plasma concentrations, thereby minimizing exercise-induced drops in ATP levels.

    “chronic supplementation with ATP increases the capacity to synthesize ATP within the erythrocytes without increasing resting concentrations in the plasma, thereby minimizing exercise-induced drops in ATP levels [242].”

    From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [242]

    The Introduction and “Effects of oral ATP on metabolite concentration levels” state that chronic oral supplementation increases erythrocyte ATP-synthesis capacity without raising resting systemic plasma ATP. The paper reports sustained blood ATP after intense exercise, but describes the proposed link between erythrocyte synthesis and prevention of exercise-related ATP drops as a suggested mechanism, not an established cause. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • ATP may increase blood flow to exercising muscle and may reduce fatigue and increase peak power output during later bouts of repeated exercise.

    “ATP may increase blood flow to the exercising muscle [244] and may reduce fatigue and increase peak power output during later bouts of repeated bouts exercise [242].”

    From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [242]

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Research works printed but not linked: 1

  1. Cronin JB, 2005, J Strength Cond Res, 19, 349

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Metadata

Authors
Purpura, M., Rathmacher, J. A., Sharp, M. H., Lowery, R. P., Shields, K. A., Partl, J. M., Wilson, J. M., & Jäger, R.
Affiliations
  • Increnovo LLC (United States) (US)
  • Iowa State University (US)
  • University of Tampa (US)
  • Applied Science and Performance Institute, Tampa, Florida, USA
Corresponding author
Purpura, Martin
ORCID
Venue
Journal of the American College of Nutrition
Publisher
Informa UK Limited
Published
2017-01-12
Volume
36
Issue
3
Pages
177-183
ISSN
  • 0731-5724 (ISSN-L)
  • 1541-1087
DOI
10.1080/07315724.2016.1246989
OpenAlex
W2577017326
Cited by
29
References
31
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 4
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Metabolic Technologies
  • University of Tampa
  • World Anti-Doping Agency
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
adenosine 5'-triphosphate, muscle excitability, muscle activation, repeated sprint performance, peak power, adenosine 5'-diphosphate, adenosine monophosphate, athletic performance
MeSH terms
Adenosine Triphosphate, Administration, Oral, Adolescent, Double-Blind Method, Humans, Male, Exercise, Muscle, Skeletal, Athletic Performance, Young Adult

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