The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Hypoxia: A Double-Edged Sword in Cancer Therapy
Abstract
Hypoxia is a common feature of malignant tumors. There is an interactive connection between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis. Therefore, tumor hypoxia has been considered as a validated target for treating cancer. This review focuses on the role of hypoxia on chemoresistance and radioresistance. In addition, we address several approaches targeting tumor hypoxia, known as hypoxia-targeted therapy.
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“Other major therapeutic modality of cancers is radiotherapy, however, it requires optimal normoxic conditions [62].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [62]
Citations
Cites
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Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Cellular Stress Responses in Radiotherapy
Kim, W., Lee, S., Seo, D., Kim, D., Kim, K., Kim, E., Kang, J., Seong, K. M., Youn, H., & Youn, B. (2019) · Cells · doi:10.3390/cells8091105 · Cited by 370
Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model
Huang, Z., Yu, P., & Tang, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249756 · Cited by 242
Hypoxia and HIF Signaling: One Axis with Divergent Effects
Corrado, C., & Fontana, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165611 · Cited by 184
Targeting Hypoxia: Hypoxia-Activated Prodrugs in Cancer Therapy
Li, Y., Zhao, L., & Li, X.-F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.700407 · Cited by 172
Metadata
- Authors
- Manoochehri Khoshinani, H., Afshar, S., & Najafi, R.
- Affiliations
- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
- Hamedan University of Medical Sciences (IR)
- Corresponding author
- Najafi, Rezvan
- Venue
- Cancer Investigation
- Publisher
- Informa UK Limited
- Published
- 2016-11-08
- Volume
- 34
- Issue
- 10
- Pages
- 536-545
- ISSN
- 0735-7907 (ISSN-L)
- 1532-4192
- OpenAlex
- W2549122510
- Cited by
- 147
- References
- 99
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 14 · 2022: 29 · 2021: 32 · 2020: 27 · 2019: 14 · 2018: 8 · 2017: 3
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor hypoxia, chemoresistance, radioresistance (biology), hypoxia-targeted therapy, tumor angiogenesis, tumor invasion, cancer therapy
- MeSH terms
- Hypoxia, Antineoplastic Agents, Combined Modality Therapy, Humans, Immunity, Neoplasms, Radiation Tolerance, Genetic Therapy, Signal Transduction, Drug Resistance, Neoplasm, Hypoxia-Inducible Factor 1, Molecular Targeted Therapy, Tumor Microenvironment
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