Hypoxia: A Double-Edged Sword in Cancer Therapy

Targeting HIF-1 for cancer therapy

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Targeting hypoxia in cancer therapy

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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation

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Role of oxygen radicals in DNA damage and cancer incidence

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Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

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The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

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Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

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Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

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Phototherapy in cancer treatment: strategies and challenges

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Cellular Stress Responses in Radiotherapy

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Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model

Huang, Z., Yu, P., & Tang, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249756 · Cited by 242

Hypoxia and HIF Signaling: One Axis with Divergent Effects

Corrado, C., & Fontana, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165611 · Cited by 184

Targeting Hypoxia: Hypoxia-Activated Prodrugs in Cancer Therapy

Li, Y., Zhao, L., & Li, X.-F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.700407 · Cited by 172

Exercise as adjunct therapy in cancer

Ashcraft, K. A., Warner, A. B., Jones, L. W., & Dewhirst, M. W. (2019) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2018.10.001 · Cited by 148

Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia

Cheng, W., Li, S., Wen, X., Han, S., Wang, S., Han, W., Song, Z., Wang, Y., Tian, X., & Zhang, X. (2021) · Chemical Communications · doi:10.1039/d1cc05715d · Cited by 129

Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling

Wang, Z., Ma, L., Su, M., Zhou, Y., Mao, K., Li, C., Peng, G., Zhou, C., Shen, B., & Dou, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0223-0 · Cited by 122

Biomedical applications of MnO2 nanomaterials as nanozyme-based theranostics

Sisakhtnezhad, S., Rahimi, M., & Mohammadi, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114833 · Cited by 127

Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

Niu, Y., Lin, Z., Wan, A., Sun, L., Yan, S., Liang, H., Zhan, S., Chen, D., Bu, X., Liu, P., et al. (2021) · Hepatology · doi:10.1002/hep.31846 · Cited by 115

Hypoxia Signaling in Cancer: From Basics to Clinical Practice

Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110

Roles of Ceramides and Other Sphingolipids in Immune Cell Function and Inflammation

Albeituni, S., & Stiban, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_15 · Cited by 111

Detailed resume of RNA m6A demethylases

Shen, D., Wang, B., Gao, Y., Zhao, L., Bi, Y., Zhang, J., Wang, N., Kang, H., Pang, J., Liu, Y., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.003 · Cited by 94

Hypoxia-dependent drivers of melanoma progression

D’Aguanno, S., Mallone, F., Marenco, M., Bufalo, D. D., & Moramarco, A. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01926-6 · Cited by 96

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types

Miar, A., Arnaiz, E., Bridges, E., Beedie, S., Cribbs, A. P., Downes, D. J., Beagrie, R., Rehwinkel, J., & Harris, A. L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2306 · Cited by 86

Colon cancer cells secrete exosomes to promote self-proliferation by shortening mitosis duration and activation of STAT3 in a hypoxic environment

Ren, R., Sun, H., Ma, C., Liu, J., & Wang, H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0325-8 · Cited by 73

Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes

Valle‐Mendiola, A., & Soto‐Cruz, I. (2020) · Cancers · doi:10.3390/cancers12010124 · Cited by 73

Chitosan oligosaccharide decorated liposomes combined with TH302 for photodynamic therapy in triple negative breast cancer

Ding, Y., Yang, R., Yu, W., Hu, C., Zhang, Z., Liu, D., An, Y., Wang, X., He, C., Liu, P., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00891-8 · Cited by 72

Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects

Nath, J., Paul, R., Ghosh, S. K., Paul, J., Singha, B., & Debnath, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118189 · Cited by 71

Mechanisms of docetaxel resistance in prostate cancer: The key role played by miRNAs

Rizzo, M. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188481 · Cited by 69

Intermittent hypoxia and cancer: Undesirable bed partners?

Almendros, I., & Gozal, D. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.08.008 · Cited by 69

Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?

Taghizadeh-Anvar, M., Rashidan, K., Arsam, N., Rasouli‐Saravani, A., Yadegari, H., Ahmadi, A., Asgari, Z., Vanan, A. G., Ghorbaninezhad, F., & Tahmasebi, S. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03525-9 · Cited by 67

B7-H3 Induces Ovarian Cancer Drugs Resistance Through An PI3K/AKT/BCL-2 Signaling Pathway

Zhou, L., & Zhao, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s222224 · Cited by 60

Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer

Jiang, L., Li, Y., He, Y., Wei, D., Yan, L., & Wen, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.711207 · Cited by 57

Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities

Sin, Q. S., Mohan, C. D., Goh, R. M., You, M., Nayak, S. C., Chen, L., Sethi, G., Rangappa, K. S., & Wang, L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10071-1 · Cited by 56

The role of tumor microenvironment on cancer stem cell fate in solid tumors

Razi, S., Haghparast, A., Khameneh, S. C., Sadrabadi, A. E., Aziziyan, F., Bakhtiyari, M., Nabi‐Afjadi, M., Tarhriz, V., Jalili, A., & Zalpoor, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01129-w · Cited by 56

The critical role of microRNAs in stress response: Therapeutic prospect and limitation

Du, J., Li, M., Huang, Q., Liu, W., Li, W., Li, Y., & Gong, Z. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.007 · Cited by 57

Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia

Zhang, C.-Y., Jiang, Z., Ma, X., Li, Y., Liu, X., Li, L., Wu, W., & Wang, T. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01039 · Cited by 54

The pH-dependent multiple nanozyme activities of copper-cerium dioxide and its application in regulating intracellular oxygen and hydrogen peroxide levels

Liu, J., Zhu, Y., Fan, Y. J., Gong, L., Zhu, X., Zhang, Y., Liu, M., & Yao, S. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.10.050 · Cited by 51

Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization

Chen, M., Li, J., Shu, G., Shen, L., Qiao, E., Zhang, N., Fang, S., Chen, X., Zhao, Z., Tu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01385-x · Cited by 52

Radioresistance of Non-Small Cell Lung Cancers and Therapeutic Perspectives

Césaire, M., Montanari, J., Curcio, H., Lerouge, D., Gervais, R., Demontrond, P., Balosso, J., & Chevalier, F. (2022) · Cancers · doi:10.3390/cancers14122829 · Cited by 49

Long-Noncoding RNA (lncRNA) in the Regulation of Hypoxia-Inducible Factor (HIF) in Cancer

Barth, D. A., Prinz, F., Teppan, J., Jonas, K., Klec, C., & Pichler, M. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030027 · Cited by 53

Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis

Zhang, Y., Wang, S., Zhang, J., Liu, C., Li, X., Guo, W., Duan, Y.-J., Chen, X., Zong, S.-Y., Zheng, J., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-021-00814-7 · Cited by 49

NEAT1 and Paraspeckles in Cancer Development and Chemoresistance

Pisani, G., & Baron, B. (2020) · Non-Coding RNA · doi:10.3390/ncrna6040043 · Cited by 49

High throughput microfluidic system with multiple oxygen levels for the study of hypoxia in tumor spheroids

Berger Fridman, I., Ugolini, G. S., VanDelinder, V., Cohen, S., & Konry, T. (2021) · Biofabrication · doi:10.1088/1758-5090/abdb88 · Cited by 46

Influence of tumor necrosis on treatment sensitivity and long-term survival in nasopharyngeal carcinoma

Liang, S., Chen, L., Yang, X., Chen, D., Wang, D., Cui, C., Xie, C., Liu, L., & Xu, X. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.11.011 · Cited by 46

Propofol inhibits pancreatic cancer progress under hypoxia via ADAM 8

Gao, Y., Yu, X., Zhang, F., & Dai, J. (2019) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.624 · Cited by 45

Tumor microenvironment‐regulating nanomedicine design to fight multi‐drug resistant tumors

Xu, Q., Lan, X., Lin, H., Xi, Q., Wang, M., Quan, X., Yao, G., Yu, Z., Wang, Y., & Yu, M. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1842 · Cited by 45

Expanding the Limits of Photodynamic Therapy: The Design of Organelles and Hypoxia-Targeting Nanomaterials for Enhanced Photokilling of Cancer

Calori, I. R., Bi, H., & Tedesco, A. C. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00945 · Cited by 45

Recent Advances in Perfluorocarbon-Based Delivery Systems for Cancer Theranostics

Yang, Y., Liu, Y., & Jiang, Y. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00116 · Cited by 44

The Many Faces of Long Noncoding RNAs in Cancer

Wu, X., Tudoran, O. M., Călin, G. A., & Ivan, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7293 · Cited by 40

Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

Xu, M., Wang, P., Sun, S., Gao, L., Sun, L., Zhang, L., Zhang, J., Wang, S., & Liang, X. (2020) · Nanoscale · doi:10.1039/d0nr05501h · Cited by 40

Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

Shi, H., Chen, L., Liu, Y., Wen, Q., Lin, S., Wen, Q., Lu, Y., Dai, J., Li, J., Xiao, S., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s396863 · Cited by 40

A Multimodal Therapeutic Nanoplatform Overcoming Tumor Hypoxia Heterogeneity for Improved Tumor Chemoradiotherapy

Zhang, L., Du, X., Li, Q., Qian, L., Chen, J., Liu, C., Yu, Q., & Gan, Z. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204629 · Cited by 40

Hypoxia promotes osteosarcoma cell proliferation and migration through enhancing platelet-derived growth factor-BB/platelet-derived growth factor receptor-β axis

Zhang, D., Cui, G., Sun, C., Li, L., Lei, L., Williamson, R. A., Wang, Y., Zhang, J., Chen, P., Wang, A., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.040 · Cited by 38

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration

Zeng, Z., Lei, S., He, Z., Chen, T., & Jiang, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29995 · Cited by 37

Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Luongo, M., Marinelli, O., Zeppa, L., Aguzzi, C., Morelli, M. B., Amantini, C., Frassineti, A., di Costanzo, M., Fanelli, A., Santoni, G., et al. (2020) · Cancers · doi:10.3390/cancers12102774 · Cited by 42

Cancer Stemness-Based Prognostic Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma

Li, N., Li, Y., Zheng, P., & Zhan, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.755805 · Cited by 37

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

Lazzari, F. D., Prag, H. A., Gruszczyk, A. V., Whitworth, A. J., & Bisaglia, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101884 · Cited by 36

Multifunctional Hybrid Hydrogel Enhanced Antitumor Therapy through Multiple Destroying DNA Functions by a Triple‐Combination Synergistic Therapy

Zhang, J., Yang, L., Huang, F., Zhao, C., Liu, J., Zhang, Y., & Liu, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101190 · Cited by 35

Determination of hypoxia signature to predict prognosis and the tumor immune microenvironment in melanoma

Shou, Y., Yang, L., Yang, Y., Zhu, X., Feng, L., & Xu, J. (2021) · Molecular Omics · doi:10.1039/d0mo00159g · Cited by 34

Hypoxia in Lung Cancer Management: A Translational Approach

Ancel, J., Perotin, J., Dewolf, M., Launois, C., Mulette, P., Nawrocki‐Raby, B., Dalstein, V., Gilles, C., Deslée, G., Polette, M., et al. (2021) · Cancers · doi:10.3390/cancers13143421 · Cited by 32

Bioluminescent Probe for Tumor Hypoxia Detection via CYP450 Reductase in Living Animals

Gao, Y., Lin, Y., Liu, T., Chen, H., Yang, X., Tian, C., Du, L., & Li, M. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03597 · Cited by 31

Intermittent hypoxia inhibits anti-tumor immune response via regulating PD-L1 expression in lung cancer cells and tumor-associated macrophages

Cui, Z., Ruan, Z., Li, M., Ren, R., Ma, Y., Zeng, J., Sun, J., Ye, W., Xu, W., Guo, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110652 · Cited by 30

The effect of hypoxia on PD-L1 expression in bladder cancer

Smith, V., Mukherjee, D., Lunj, S., Choudhury, A., Hoskin, P., West, C., & Illidge, T. (2021) · BMC Cancer · doi:10.1186/s12885-021-09009-7 · Cited by 30

LncRNA GHET1 Promotes Hypoxia-Induced Glycolysis, Proliferation, and Invasion in Triple-Negative Breast Cancer Through the Hippo/YAP Signaling Pathway

Wang, Y., & Liu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.643515 · Cited by 29

Anti-cancer strategy targeting the energy metabolism of tumor cells surviving a low-nutrient acidic microenvironment

Maeda, Y., Kikuchi, R., Kawagoe, J., Tsuji, T., Koyama, N., Yamaguchi, K., Nakamura, H., & Aoshiba, K. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101093 · Cited by 27

Identification of Key Gene Targets for Sensitizing Colorectal Cancer to Chemoradiation: an Integrative Network Analysis on Multiple Transcriptomics Data

Manoochehri, H., Jalali, A., Tanzadehpanah, H., Taherkhani, A., & Saidijam, M. (2021) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-021-00690-2 · Cited by 28

Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells.

Xu, Q., Liu, Z., Guo, L., Liu, R., Li, R., Chu, X., Yang, J., Luo, J., Chen, F., & Deng, M. (2019) · PubMed Central · doi:10.14348/molcells.2019.0023 · Cited by 27

Identification of Signatures of Prognosis Prediction for Melanoma Using a Hypoxia Score

Shou, Y., Yang, L., Yang, Y., Zhu, X., Li, F., & Xu, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.570530 · Cited by 27

Glucose transporter 1 (GLUT1)-targeting and hypoxia-activated mitochondria-specific chemo-thermal therapy via a glycosylated poly(amido amine)/celastrol (PAMAM/Cel) complex

Wei, G., Chen, J., Jing, Z., Li, Y., Li, Z., Zheng, W., Sun, X.-R., Zhao, W., Zhang, Z., Wang, X., et al. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.10.129 · Cited by 27

The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy

Carvalho, T. M. A., Cardoso, H. J., Figueira, M. I., Vaz, C. V., & Socorro, S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.03.053 · Cited by 27

Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance

Li, C., Wu, X., Zheng, C., Xu, S., Liu, Y., Qin, J., Fan, X., Ye, Y., & Fei, W. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01350a · Cited by 26

Enhanced anti‐angiogenic activity of novel melatonin‐like agents

Hwang, S. J., Jung, Y., Song, Y., Park, S., Park, Y., & Lee, H. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12739 · Cited by 25

IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation

Muller, A. J., Mondal, A., Dey, S., & Prendergast, G. C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1165298 · Cited by 25

Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”

Wu, J., Long, Y., Li, M., & He, Q. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.024 · Cited by 24

Investigation into the association between obstructive sleep apnea and incidence of all-type cancers: a systematic review and meta-analysis

Cheng, H., & Li, D. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.05.031 · Cited by 25

Hypoxia upregulates the expression of lncRNA H19 in non-small cell lung cancer cells and induces drug resistance

Li, H., Wang, J., Jin, Y., Lin, J., Gong, L., & Xu, Y. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-1812 · Cited by 24

HIF-1-dependent heme synthesis promotes gemcitabine resistance in human non-small cell lung cancers via enhanced ABCB6 expression

Xiang, L., Wang, Y., Lan, J., Na, F., Wu, S., Gong, Y., Du, H., Shao, B., & Xie, G. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04360-9 · Cited by 24

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis, K., & Angelopoulou, A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020179 · Cited by 23

Upregulation of lncRNA AGAP2‑AS1 is an independent predictor of poor survival in patients with clear cell renal carcinoma

Gao, L., Zhao, A., & Wang, X. (2020) · Oncology Letters · doi:10.3892/ol.2020.11484 · Cited by 22

Novel Carbon Ion and Proton Partial Irradiation of Recurrent Unresectable Bulky Tumors (Particle-PATHY): Early Indication of Effectiveness and Safety

Tubin, S., Fossati, P., Carlino, A., Martino, G., Góra, J., Stock, M., & Hug, E. B. (2022) · Cancers · doi:10.3390/cancers14092232 · Cited by 21

Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p

Xu, J., Du, L., Shi, S., Niu, A., Wu, J., Wang, Y., & Wang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.806682 · Cited by 21

Influence of Body Mass Index on the Clinicopathologic Features of Papillary Thyroid Carcinoma

Feng, J., Yang, X., Wu, B., Sun, D., Jiang, Y., & Qu, Z. (2019) · Annals of Otology Rhinology & Laryngology · doi:10.1177/0003489419834314 · Cited by 22

Role of hyperoxic treatment in cancer

Kim, S. W., Kim, I. K., & Lee, S. H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220921547 · Cited by 20

Immunotherapy-based novel nanoparticles in the treatment of gastrointestinal cancer: Trends and challenges

Ding, Y., Xue, M., Tang, Q., Wang, L., Ding, H.-Y., Li, H., Gao, C., & Yu, W. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i37.5403 · Cited by 21

Novel Quinoxaline-2-Carbonitrile-1,4-Dioxide Derivatives Suppress HIF1α Activity and Circumvent MDR in Cancer Cells

Scherbakov, A. M., Borunov, A. M., Buravchenko, G. I., Andreeva, O. E., Kudryavtsev, I. A., Dezhenkova, L. G., & Shchekotikhin, A. E. (2018) · Cancer Investigation · doi:10.1080/07357907.2018.1453072 · Cited by 19

LCN2 Is a Potential Biomarker for Radioresistance and Recurrence in Nasopharyngeal Carcinoma

Zhang, M., Wang, L., Zeng, L., & Tu, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.605777 · Cited by 19

Non-Invasive Assessment of Hypoxia and Neovascularization with MRI for Identification of Aggressive Breast Cancer

Bennani‐Baïti, B., Pinker, K., Zimmermann, M., Helbich, T. H., Baltzer, P., Clauser, P., Kapetas, P., Bagó-Horváth, Z., & Stadlbauer, A. (2020) · Cancers · doi:10.3390/cancers12082024 · Cited by 18

Melatonin modifies tumor hypoxia and metabolism by inhibiting HIF-1α and energy metabolic pathway in the in vitro and in vivo models of breast cancer

Mota, A. D. L., Jardim‐Perassi, B. V., de Castro, T. B., Colombo, J., Sonehara, N. M., Nishiyama, V. K. G., Pierri, V. A. G., & Zuccari, D. A. P. D. C. (2019) · Melatonin Research · doi:10.32794/mr11250042 · Cited by 18

Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes

Harmouch, E., Seitlinger, J., Chaddad, H., Ubeaud-Séquier, G., Barths, J., Sani, S., Désaubry, L., Grandemange, S., Massfelder, T., Fuhrmann, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70820-6 · Cited by 15

Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer

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A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation

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