The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Gender differences in neurodevelopmental outcomes among extremely preterm, extremely‐low‐birthweight infants
Abstract
AIM: To determine whether gender-specific responses to perinatal and neonatal events and exposures explain the male disadvantage in early childhood outcomes. METHODS: Infants were in the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network, born 1/1/1997-12/31/2000, <28 wk, with neurodevelopmental follow-up at 18-22 mo corrected age. We evaluated and compared univariate and multivariate associations of risk factors with neurodevelopmental outcomes for girls and boys. Neurodevelopmental impairment (NDI) was one or more of the following: moderate--severe cerebral palsy (CP), Bayley Mental (MDI) or Psychomotor (PDI) Development Indices <70, deafness or blindness. RESULTS: Boys (n=1216) were more likely than girls (n=1337) to have adverse outcomes (moderate--severe CP: 10.7% vs 7.3%; MDI < 70: 41.9% vs 27.1%; NDI: 48.1% vs 34.1%). Major risk factors were also more common in boys. Independent multivariate associations of risk factors with outcome differed by gender, but not consistently in favor of girls. In multivariate models including both girls and boys, male gender remained an independent risk factor for MDI < 70 (2.0, 95% CI 1.6-2.5) and NDI (1.8, 95% CI 1.5-2.2). CONCLUSION: Perinatal, neonatal and early childhood factors confer similar incremental risk or protection to boys and girls, but boys appear to have inherently greater baseline risk. Unmeasured biological variables likely contribute to the preterm male neurodevelopmental outcome disadvantage.
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“Biologically, male infants are more vulnerable neurodevelopmentally than female infants, especially in situations of existing biological risk, such as being born premature (Hintz et al. 2006).”
From Early Family Experiences and Neural Activity in Rural Pakistani Children: The Differential Role of Gender (2024) · cites this paper as Hintz et al. 2006
In the citing paper
“Female infants' brains have been found to be less vulnerable to neurodevelopmental risk in several contexts (Hintz et al. 2006).”
From Early Family Experiences and Neural Activity in Rural Pakistani Children: The Differential Role of Gender (2024) · cites this paper as Hintz et al. 2006
Citations
Cites
Palisano, R. J., Rosenbaum, P., Walter, S. D., Russell, D., Wood, E. P., & Galuppi, B. E. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07414.x · Cited by 6,728
Papile, L. A., Burstein, J., Burstein, R., & Koffler, H. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80282-0 · Cited by 6,435
Neurologic and Developmental Disability at Six Years of Age after Extremely Preterm Birth
Marlow, N., Dieter Wolke, C., Bracewell, M. A., & Samara, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041367 · Cited by 1,897
Necrotizing Enterocolitis: Treatment Based on Staging Criteria
Walsh, M. C., & Kliegman, R. M. (1986) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)34975-6 · Cited by 1,870
Lemons, J. A., Bauer, C. R., Oh, W., Korones, S. B., Papile, L. A., Stoll, B. J., Verter, J. I., Temprosa, M. G., Wright, L. L., Ehrenkranz, R. A., et al. (2001) · PEDIATRICS · doi:10.1542/peds.107.1.e1 · Cited by 1,441
Neurologic and Developmental Disability after Extremely Preterm Birth
Wood, N. S., Marlow, N., Costeloe, K., Gibson, A. T., & Wilkinson, A. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008103430601 · Cited by 1,351
Outcomes in Young Adulthood for Very-Low-Birth-Weight Infants
Hack, M., Flannery, D. J., SCHLUCHTER, M. D., Cartar, L., Borawski, E. A., & Klein, N. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010856 · Cited by 1,200
Vohr, B. R., Wright, L. L., Dusick, A. M., Mele, L., Verter, J. I., Steichen, J. J., Simon, N. P., Wilson-Costello, D., Broyles, S., Bauer, C. R., et al. (2000) · PEDIATRICS · doi:10.1542/peds.105.6.1216 · Cited by 1,143
Self-citationHack, M., Taylor, H. G., Drotar, D., Schluchter, M., Cartar, L., Wilson-Costello, D. E., Klein, N., Friedman, H., Minich, N. M., & Morrow, M. (2005) · PEDIATRICS · doi:10.1542/peds.2005-0173 · Cited by 604
Cerebral White Matter Injury of the Premature Infant—More Common Than You Think
Volpe, J. J. (2003) · PEDIATRICS · doi:10.1542/peds.112.1.176 · Cited by 538
Fanaroff, A. A., Wright, L. L., Stevenson, D. K., Shankaran, S., Donovan, E. P., Ehrenkranz, R. A., Younes, N., Korones, S. B., Stoll, B. J., Tyson, J. E., et al. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90628-2 · Cited by 519
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
Gur, R., Mozley, P., Resnick, S., Gottlieb, G., Kohn, M., Zimmerman, R. A., Herman, G., Atlas, S. J., Grossman, R., & Berretta, D. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.7.2845 · Cited by 467
Wood, N. S., Costeloe, K., Gibson, A. T., Hennessy, E. M., Marlow, N., & Wilkinson, A. R. (2005) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/adc.2004.052407 · Cited by 419
Inder, T. E., Anderson, N. J., Spencer, C., Wells, S., & Volpe, J. J. (2003) · PubMed Central · Cited by 378
Stevenson, D., Wright, L., Lemons, J., Oh, W., Korones, S., Papile, L., Bauer, C., Stoll, B., Tyson, J., Shankaran, S., et al. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70037-7 · Cited by 359
Neurodevelopment and Predictors of Outcomes of Children With Birth Weights of Less Than 1000 g
Hack, M., Wilson-Costello, D. E., Friedman, H., Taylor, G. H., SCHLUCHTER, M. D., & Fanaroff, A. A. (2000) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.154.7.725 · Cited by 356
Sex differences in aging of the human frontal and temporal lobes
Cowell, P. E., Turetsky, B. I., Gur, R., Grossman, R. I., Shtasel, D. L., & Gur, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04748.1994 · Cited by 336
The Bayley Scales of Infant Development II
GAUTHIER, S. M., Bauer, C. R., Messinger, D. S., & CLOSIUS, J. M. (1999) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199904000-00001 · Cited by 304
Hoekstra, R. E., Ferrara, T., Couser, R. J., Payne, N. R., & Connett, J. E. (2004) · PEDIATRICS · doi:10.1542/peds.113.1.e1 · Cited by 196
Preterm male infants need more initial respiratory and circulatory support than female infants
Elsmén, E., Pupp, I. H., & Hellström-Westas, L. K. (2004) · Acta Paediatrica · doi:10.1080/08035250410024998 · Cited by 175
Prevention of intraventricular hemorrhage by indomethacin in male preterm infants
Ment, L. R., Vohr, B. R., Makuch, R., Westerveld, M., Katz, K. H., Schneider, K. C., Duncan, C. C., Ehrenkranz, R. A., Oh, W. K., Philip, A. G. S., et al. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.07.035 · Cited by 144
Self-citationPrognosis of the very low birthweight baby in relation to gender.
BROTHWOOD, M., Dieter Wolke, C., Gamsu, H. R., Benson, J. T., & Cooper, D. (1986) · Archives of Disease in Childhood · doi:10.1136/adc.61.6.559 · Cited by 137
Birth Weight Less Than 800 Grams: Changing Outcomes and Influences of Gender and Gestation Number
Hoffman, E. L., & Bennett, F. C. (1990) · PEDIATRICS · doi:10.1542/peds.86.1.27 · Cited by 110
Gender differences in cognitive abilities at 2 years in ELBW infants
Hindmarsh, G., O'Callaghan, M. J., Mohay, H. A., & Rogers, Y. (2000) · Early Human Development · doi:10.1016/s0378-3782(00)00105-5 · Cited by 103
Ingemarsson, I., Herbst, A., & Thorngren‐Jerneck, K. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb10934.x · Cited by 75
Victorian Infant Collaborative Study Group (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80044-7 · Cited by 70
FOLLOW-UP MANAGEMENT OF THE HIGH RISK INFANT.
Bain, J. (1988) · Europe PMC (PubMed Central) · Cited by 58
El‐Khodor, B. F. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00079-7 · Cited by 52
Bry, K., Lappalainen, U., Waffarn, F., Teramo, K., & Hallman, M. (1994) · Pediatric Research · doi:10.1203/00006450-199401000-00029 · Cited by 37
Predictors of Mortality, Morbidity, and Disability in a Cohort of Infants ≤ 28 Weeks' Gestation
Msall, M. E., Louis, G. M. B., Rogers, B., Duffy, L. C., Mallen, S. R., & Catanzaro, N. L. (1993) · Clinical Pediatrics · doi:10.1177/000992289303200903 · Cited by 31
Cited by
Sorted by citations
Larroque, B., Ancel, P., Marret, S., Marchand‐Martin, L., André, M., Arnaud, C., Pierrat, V., Rozé, J., Messer, J., Thiriez, G., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60380-3 · Cited by 935
Preterm Birth and Childhood Psychiatric Disorders
Johnson, S. J., & Marlow, N. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212faa0 · Cited by 648
Serenius, F., Källén, K., Blennow, M., Ewald, U., Fellman, V., Holmström, G., Lindberg, E., Lundqvist, P., Maršál, K., Norman, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.3786 · Cited by 558
Neurodevelopmental Outcomes of Preterm Infants Fed High-Dose Docosahexaenoic Acid
Makrides, M., Gibson, R. A., McPhee, A. J., Collins, C. T., Davis, P. G., Doyle, L. W., Simmer, K. N., Colditz, P. B., Morris, S. A., Smithers, L. G., et al. (2009) · JAMA · doi:10.1001/jama.2008.945 · Cited by 380
Linsell, L., Malouf, R. S., Morris, J. K., Kurinczuk, J. J., & Marlow, N. (2015) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2015.2175 · Cited by 406
Metadata
- Authors
- Hintz, S. R., Kendrick, D. E., Vohr, B. R., Poole, W. K., Higgins, R. D., & For The Nichd Neonatal Research Network
- Affiliations
- Stanford Medicine (US)
- Women & Infants Hospital of Rhode Island (US)
- RTI International (US)
- National Institutes of Health (US)
- Corresponding author
- Hintz, Susan R.
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2006-10
- Volume
- 95
- Issue
- 10
- Pages
- 1239-1248
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2101903842
- Cited by
- 304
- References
- 31
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 18 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 21 · 2019: 21 · 2018: 20 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 16 · 2012: 16
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- gender differences, neurodevelopmental outcomes, extremely preterm infants, extremely low birth weight infants, cerebral palsy, Bayley Scales of Infant Development, neurodevelopmental impairment, risk factors, perinatal exposure, neonatal exposure, NICHD Neonatal Research Network
- MeSH terms
- Cerebral Palsy, Developmental Disabilities, Female, Humans, Infant, Newborn, Infant, Premature, Male, Motor Skills, Risk Factors, Sex Factors, Multivariate Analysis, Infant, Very Low Birth Weight
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