Bench to bedside: new approaches to the immunotherapy of uveitic disease
Abstract
Intraocular inflammatory disease, or uveitis, appears to be due in large part to non-infectious, cell-mediated mechanisms. Experimental autoimmune uveitis (EAU) has been a valuable tool to better understand underlying mechanisms of this disorder, and it provides the possibility to evaluate new approaches to immunotherapy as well. Two approaches described here are oral tolerance and anti-IL2 receptor therapy. Both therapies were evaluated in the animal model and showed positive therapeutic effects. Based on these observations, both approaches were used in the treatment of patients with uveitis. Oral tolerance showed initial promising results. Anti-IL2 receptor therapy has been used for over 4 years in uveitis patients with an additional study evaluating this therapy in Behçet's disease. Future plans are to expand this approach to a larger number of patients. The use of animal models has been very useful in better understanding mechanisms of ocular disease and bringing new therapeutic approaches to the clinic.
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The usage of cyclosporine, rapamycin, or daclizumab for uveitis is based on its effectiveness in experimental autoimmune uveitis.
“the usage of cyclosporine, rapamycin, or daclizumab for uveitis is based on its effectiveness in experimental autoimmune uveitis”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Nussenblatt, 2002
There are successful therapies for human disease that arose from mouse models.
“there are successful therapies for human disease that arose from mouse models”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Nussenblatt, 2002
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Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works
- Authors
- NUSSENBLATT, R. B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- NUSSENBLATT, ROBERT B.
- Venue
- International Reviews of Immunology
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 21
- Issue
- 2-3
- Pages
- 273-289
- ISSN
- 0883-0185 (ISSN-L)
- 1563-5244
- OpenAlex
- W1971097727
- Cited by
- 72
- References
- 28
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Reviews of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Keywords
- uveitis, experimental autoimmune uveitis, immunotherapy, oral tolerance, interleukin-2, Behçet's disease, intraocular inflammation
- MeSH terms
- Daclizumab, Animals, Antibodies, Monoclonal, Autoimmune Diseases, Behcet Syndrome, Humans, Immunoglobulin G, Immune Tolerance, Immunotherapy, Uveitis, Receptors, Interleukin-2, Antibodies, Monoclonal, Humanized
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