Cited by 72Ocular Diseases and Behçet’s SyndromeT-cell and B-cell ImmunologyOcular Oncology and Treatments

Bench to bedside: new approaches to the immunotherapy of uveitic disease

NUSSENBLATT, ROBERT B.·2002·International Reviews of Immunology

Abstract

Intraocular inflammatory disease, or uveitis, appears to be due in large part to non-infectious, cell-mediated mechanisms. Experimental autoimmune uveitis (EAU) has been a valuable tool to better understand underlying mechanisms of this disorder, and it provides the possibility to evaluate new approaches to immunotherapy as well. Two approaches described here are oral tolerance and anti-IL2 receptor therapy. Both therapies were evaluated in the animal model and showed positive therapeutic effects. Based on these observations, both approaches were used in the treatment of patients with uveitis. Oral tolerance showed initial promising results. Anti-IL2 receptor therapy has been used for over 4 years in uveitis patients with an additional study evaluating this therapy in Behçet's disease. Future plans are to expand this approach to a larger number of patients. The use of animal models has been very useful in better understanding mechanisms of ocular disease and bringing new therapeutic approaches to the clinic.

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Crossref · 10.1080/08830180212067

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Authors
NUSSENBLATT, R. B.
Affiliations
National Institutes of Health (US)
Corresponding author
NUSSENBLATT, ROBERT B.
Venue
International Reviews of Immunology
Published
2002-01
Volume
21
Issue
2-3
Pages
273-289
ISSN
  • 0883-0185 (ISSN-L)
  • 1563-5244
OpenAlex
W1971097727
Cited by
72
References
28
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4
FWCI
3.64
Type
journal article
Language
en
Open access
closed
Locations
  • International Reviews of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
Keywords
uveitis, experimental autoimmune uveitis, immunotherapy, oral tolerance, interleukin-2, Behçet's disease, intraocular inflammation
MeSH terms
Daclizumab, Animals, Antibodies, Monoclonal, Autoimmune Diseases, Behcet Syndrome, Humans, Immunoglobulin G, Immune Tolerance, Immunotherapy, Uveitis, Receptors, Interleukin-2, Antibodies, Monoclonal, Humanized

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