Dry needling and upper cervical spinal manipulation in patients with temporomandibular disorder: A multi-center randomized clinical trial
Open accessAbstract
Objective To compare the effects of dry needling and upper cervical spinal manipulation with interocclusal splint therapy, diclofenac, and temporomandibular joint (TMJ) mobilization in patients with temporomandibular disorder (TMD). Methods One hundred-twenty patients with TMD were randomized to receive six treatment sessions of dry needling plus upper cervical spinal manipulation (n = 62) or interocclusal splint therapy, diclofenac, and joint mobilization to the TMJ (n = 58). Results Patients receiving dry needling and upper cervical spinal manipulation experienced significantly greater reductions in jaw pain intensity over the last 7 days (VAS: F = 23.696; p p Conclusion Dry needling and upper cervical spinal manipulation was more effective than interocclusal splint therapy, diclofenac, and TMJ mobilization in patients with TMD.
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Manual therapy was effective in reducing pain immediately after treatment, independent of the professional category.
“Manual therapy was found to be effective in reducing pain immediately after treatment, independent of the professional category (Table 2).”
Comparator groups varied widely, including sham or no-treatment control, standard care, splint therapy, and pharmacological treatments.
“Comparator groups varied widely, including sham or no-treatment control [23,27], standard care [21], splint therapy [25,29,32] and pharmacological treatments [38].”
Intervention formats ranged from single-session treatments to multi-week protocols.
“intervention formats ranged from single-sessions treatments (e.g. one atlanto-occipital thrust in Oliveira-Campelo et al. [26]) to multi-week protocols (e.g. eight sessions of dry-needling combined with upper cervical HVLA over four weeks in Dunning et al. [25]).”
Manual therapy was effective across all professional categories, with significant reductions in pain and improvements in maximum mouth opening.
“Manual therapy was effective across all professional categories, with significant reductions in pain [21–25] and improvements in MMO [21–26].”
In this systematic review, most studies applied Axis I criteria, while a subset incorporated both Axis I and II.
“In this systematic review, most studies applied Axis I criteria [22,25,27,30,35], while a subset incorporated both Axis I and II [21,33] to identify TMD subtypes most responsive to manual therapy.”
HVLA techniques applied to the jaw and cervical spine demonstrated efficacy in reducing pain and improving maximum mouth opening.
“HVLA techniques applied to the jaw [24,29,31] and cervical spine [21,23,25–27] demonstrated efficacy in reducing pain and improving MMO.”
Dunning et al. and Kalamir et al. observed improvements within six weeks, confirming the short-term efficacy of manual therapy.
“Similarly, Dunning et al. [25] and Kalamir et al. [35] observed improvements within six weeks, confirming the short-term efficacy of manual therapy.”
Several studies emphasized that manual therapy was performed by professionals with specialized training, reinforcing the notion that clinical expertise is critical to achieving effective results.
“Several studies [21,22,25,26,29,31,34] emphasized that manual therapy was performed by professionals with specialized training, reinforcing the notion that clinical expertise is critical to achieving effective results.”
Dunning et al. demonstrated that combining dry needling with upper cervical manipulation outperformed splint therapy, diclofenac, and TMJ mobilization.
“Dunning et al. [25] demonstrated that combining dry needling combined with upper cervical manipulation outperformed splint therapy, diclofenac, and TMJ mobilization.”
For Axis I temporomandibular disorders, positive outcomes were reported with upper cervical HVLA techniques, likely due to interruption of nociceptive signaling via trigemino-cervical convergence mechanisms.
“For Axis I TMD, positive outcomes were reported with upper cervical HVLA techniques, likely due to interruption of the nociceptive signaling via trigemino-cervical convergence mechanisms [21,25,27].”
Cites
Improving the reporting of pragmatic trials: An extension of the CONSORT statement
Zwarenstein, M., Treweek, S., Gagnier, J. J., Altman, D. G., Tunis, S., Haynes, B., Oxman, A. D., Moher, D., & groups, F. T. C. A. P. T. I. H. (. (2008) · BMJ · doi:10.1136/bmj.a2390 · Cited by 1,813 · see citing works
Effectiveness of manual therapies: the UK evidence report
Bronfort, G., Haas, M., Evans, R., Leininger, B., & Triano, J. (2010) · Chiropractic & Osteopathy · doi:10.1186/1746-1340-18-3 · Cited by 434 · see citing works
Armijo-Olivo, S., Pitance, L., Singh, V., Neto, F., Thie, N., & Michelotti, A. (2016) · Physical Therapy · doi:10.2522/ptj.20140548 · Cited by 413 · cited 2× · see citing works
“A large-scale systematic review found inconclusive evidence for the use of temporomandibular joint (TMJ) mobilization alone for TMD [20]; however, the use of joint mobilization in combination with other conservative treatments, such as exercise, is supported by current literature [21–24].”
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Chiaramonte, R., Ferrillo, M., de Sire, A., & Vecchio, M. (2026) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2026.2629282
“For instance, intervention formats ranged from single-sessions treatments (e.g. one atlanto-occipital thrust in Oliveira-Campelo et al. [26]) to multi-week protocols (e.g. eight sessions of dry-needling combined with upper cervical HVLA over four weeks in Dunning et al. [25]).”
Influential
- Authors
- Dunning, J., Butts, R., Bliton, P., Vathrakokoilis, K., Smith, G., Lineberger, C., Eshleman, N., Fernández-de-Las-Peñas, C., & Young, I. A.
- Affiliations
- Universidad Rey Juan Carlos (ES)
- American Academy of Manipulative Therapy Fellowship in Orthopaedic Manual Physical Therapy, Montgomery, AL, USA
- Athens Orthopedic Clinic (US)
- Aristotle University of Thessaloniki (GR)
- Advanced Manual Therapies, Alpharetta, GA, USA
- Osteopractic Physical Therapy of the Carolinas, Fort Mill, SC, USA
- Peak Physical Therapy & Sports Rehab, Helena, MT, USA
- Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Spain
- Corresponding author
- Dunning, James
- Venue
- CRANIO®
- Publisher
- Informa UK Limited
- Published
- 2022-04-12
- Volume
- 42
- Issue
- 6
- Pages
- 809-822
- ISSN
- 0734-5410 (ISSN-L)
- 0886-9634
- 2151-0903
- OpenAlex
- W4223445268
- Cited by
- 21
- References
- 3
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 1
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- CRANIO® (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- ethics committee at Universidad Rey Juan Carlos, Madrid, Spain ((URJC-DPTO 36-2017))
- Topics
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Keywords
- temporomandibular disorders, dry needling, interocclusal splint, diclofenac, jaw pain, mouth opening, non-pharmacological treatment
- MeSH terms
- Dry Needling, Adult, Anti-Inflammatory Agents, Non-Steroidal, Cervical Vertebrae, Diclofenac, Female, Humans, Male, Middle Aged, Pain Measurement, Temporomandibular Joint Disorders, Range of Motion, Articular, Treatment Outcome, Occlusal Splints, Manipulation, Spinal, Young Adult
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