A Multisite Pilot Study of Extended-Release Injectable Naltrexone Treatment for Previously Opioid-Dependent Parolees and Probationers
Open accessAbstract
A feasibility study was conducted to pilot test the ability of 5 sites to recruit, treat, and retain opioid-dependent offenders in a trial of extended-release injectable naltrexone (XR-NTX). The participants, 61 previously opioid-dependent individuals under legal supervision in the community, received up to 6 monthly injections of Depotrex brand naltrexone and completed a 6-month follow-up interview. Six-month outcomes showed that those who completed treatment had significantly fewer opioid-positive urines and were less likely to have been incarcerated than those who had not completed treatment. The findings indicate that XR-NTX holds promise as a feasible, effective treatment option for opioid-dependent offenders.
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A prior single-group pilot study at the same five sites showed that Depotrex, an extended-release naltrexone formulation, was feasible as a treatment option for outpatient parolees and probationers.
“A pilot study that was performed at the same five sites that participated in this trial used a single-group observational cohort design and showed the feasibility of using Depotrex, an alternative formulation of extended-release naltrexone, as a treatment option for outpatient parolees and probationers.13”
From Extended-release naltrexone to prevent opioid relapse in criminal justice offenders (2016) · cites this paper as [13]
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Self-citation
- Authors
- Coviello, D. M., Cornish, J. W., Lynch, K. G., Boney, T. Y., Clark, C. A., Lee, J. D., Friedmann, P. D., Nunes, E. V., Kinlock, T. W., Gordon, M. S., Schwartz, R. P., Nuwayser, E. S., & O'Brien, C. P.
- Affiliations
- University of Pennsylvania (US)
- Philadelphia VA Medical Center (US)
- Bellevue Hospital Center (US)
- Brown University (US)
- Columbia University (US)
- Friends Research Institute (US)
- Biotek, Inc., Woburn, Massachusetts, USA
- University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Corresponding author
- Coviello, Donna M.
- ORCID
- Venue
- Substance Abuse
- Publisher
- SAGE Publications
- Published
- 2012-01
- Volume
- 33
- Issue
- 1
- Pages
- 48-59
- ISSN
- 0889-7077 (ISSN-L)
- 1547-0164
- PMC
- PMC3365863
- OpenAlex
- W2024278700
- Cited by
- 58
- References
- 45
- Citations by year
- 2022: 2 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 15 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Substance Abuse (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01-DA-012268-05, R01DA012268)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Sociology and Political Science › Criminal Justice and Corrections Analysis
- Keywords
- opioid use disorder, parolees, probationers, offender treatment, treatment retention, incarceration, feasibility, community supervision
- MeSH terms
- Adult, Delayed-Action Preparations, Feasibility Studies, Female, Follow-Up Studies, Humans, Injections, Injections, Subcutaneous, Male, Middle Aged, Naltrexone, Narcotic Antagonists, Opioid-Related Disorders, Pilot Projects, Prisoners, Young Adult, Opiate Substitution Treatment
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