Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis: a case-control study and meta-analysis
Abstract
The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800-7.813, p C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169-2.329, p = 0.004); homozygous (OR = 1.380, 95% CI = 0.906-2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001-2.428, p = 0.049); dominant (OR = 1.663, 95% CI = 1.078-2.567, p = 0.022); and recessive (OR = 1.366, 95% CI = 0.964-1.935, p = 0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361-10.190, p = 0.010); dominant (OR = 3.823, 95% CI = 1.320-11.074, p = 0.013); and recessive (OR = 4.35…
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GWAS, meta-analysis, exome analysis and SNP mapping have associated IL-6, IL-6R and gp130 with inflammatory diseases such as RA and coronary artery disease.
“Genome-wide association studies (GWAS), meta-analysis, exome analysis and single nucleotide polymorphism (SNP) mapping have associated IL-6, IL-6R and gp130 with inflammatory diseases such as RA and coronary artery disease (263–269).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [263]
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“A single polymorphism may not be sufficient to predict the risk of developing complex autoimmune diseases, like RA (Dar et al. 2017).”
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“Установлено, что частота минорного аллеля С полиморфного локуса -174G/C (rs 1800795) гена IL-6 в контрольной выборке укладывается в диапазон частот, присущих европейским популяциям (25,5–48,5 %), но отличается от таковых для азиатов (4–11 %) [9].”
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“While the case-control studies that have been done on Caucasian RA patients did not show a significant correlation between the allelic distributions of IL-6-174G>C variant and the risk of developing RA [75-77].”
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“…lin e F irs t A rtic le varied number of sample size and the uncorrected physiological status (Dar et al., 2016; Zhai et al., 2012; Dai et al., 2014; HuaLee et al., 2015; Cai et al., 2014; Chen et al., 2012; Lee et al., 2012) has prompted us to…”
Background
- Authors
- Dar, S. A., Haque, S., Mandal, R. K., Singh, T., Wahid, M., Jawed, A., Panda, A. K., Akhter, N., Lohani, M., Areeshi, M. Y., Rai, G., Datt, S., Bhattacharya, S. N., Ramachandran, V. G., & Das, S.
- Affiliations
- University of Delhi (IN)
- Jazan University (SA)
- Central University of Jharkhand (IN)
- ,
- Corresponding author
- Das, Shukla
- ORCID
- Venue
- Autoimmunity
- Publisher
- Informa UK Limited
- Published
- 2016-12-23
- Volume
- 50
- Issue
- 3
- Pages
- 158-169
- ISSN
- 0891-6934 (ISSN-L)
- 1607-842X
- OpenAlex
- W2565946906
- Cited by
- 38
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 4 · 2017: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, interleukin-6, IL-6 -174 G/C polymorphism, rs1800795, promoter polymorphism, genetic susceptibility, single nucleotide polymorphisms, disease risk association, Asian populations, Caucasian population, ethnic differences in genetic association, meta-analysis of genetic association studies
- MeSH terms
- Alleles, Arthritis, Rheumatoid, Genotype, Humans, Interleukin-6, Odds Ratio, Case-Control Studies, Publication Bias, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Population Groups, Genetic Association Studies
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